Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Katherine A. Grant-Young"'
Autor:
Katherine A. Grant-Young, Andrew Nickel, Rajesh Onkardas Bora, Prakash Anjanappa, Bender John A, Kevin Kish, Kap-Sun Yeung, Dawn D. Parker, Joseph Raybon, Mark R. Witmer, Karen Rigat, Matthew G. Soars, Steven Sheriff, Yue-Zhong Shu, Kenneth S. Santone, Prashantha Gunaga, Kyle Parcella, Nicholas A. Meanwell, Jay O. Knipe, Susan B. Roberts, Alicia Ng, Michael Sinz, Kathy Mosure, Ying-Kai Wang, Brett R. Beno, Mengping Liu, Elizabeth Colston, Dennis M. Grasela, John F. Kadow, Qi Gao, Min Gao, Umesh Hanumegowda, Roy Haskell, Julie A. Lemm, Xiaoliang Zhuo, Changhong Wan, Kumaravel Selvakumar
Publikováno v:
Journal of Medicinal Chemistry. 60:4369-4385
The hepatitis C virus (HCV) NS5B replicase is a prime target for the development of direct-acting antiviral drugs for the treatment of chronic HCV infection. Inspired by the overlay of bound structures of three structurally distinct NS5B palm site al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e500f8c2cd73d6873f1280c193d753
https://doi.org/10.1021/acs.jmedchem.7b00328
https://doi.org/10.1021/acs.jmedchem.7b00328
Autor:
Hua Fang, Kevin Kish, Mark R. Witmer, Matthew G. Soars, Kyle Parcella, Brett R. Beno, Ying-Kai Wang, Prakash Anjanappa, Julie A. Lemm, Karen Rigat, Katherine A. Grant-Young, Kap-Sun Yeung, Kathy Mosure, Steven Sheriff, Kenneth S. Santone, Jeffrey Tredup, Dawn D. Parker, John F. Kadow, Rajesh Onkardas Bora, Mengping Liu, Nicholas A. Meanwell, Susan B. Roberts, Adam G. Jardel, Rudolph G. Krause, Juliang Zhu, Kumaravel Selvakumar, Roy Haskell
[Image: see text] In solving the P-gp and BCRP transporter-mediated efflux issue in a series of benzofuran-derived pan-genotypic palm site inhibitors of the hepatitis C virus NS5B replicase, it was found that close attention to physicochemical proper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b87c17f58394ad90d7b8ea7bef1817f
https://europepmc.org/articles/PMC6295864/
https://europepmc.org/articles/PMC6295864/
Autor:
Robert G. Gentles, Michael A. Poss, Tracey Fiedler, Ronald J. Knox, David G. Harden, Shuanghua Hu, Yazhong Huang, C. J. Andres, Nicholas J. Lodge, C. David Weaver, Katherine A. Grant-Young
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:5694-5697
An exploratory SAR study on a series of potent, non-apamin-displacing 4-(aminomethylaryl)pyrazolopyrimidine KCa channel blockers is described and their selectivity against KCa channel subtypes is reported. The most potent analog, 5-chloro-N-(thiophen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bea31396fd449f218df9992fbb861d4
https://doi.org/10.1016/j.bmcl.2008.08.026
https://doi.org/10.1016/j.bmcl.2008.08.026
Autor:
and Arthur V. Miller, C. J. Andres, David S. Nirschl, Edward W. Petrillo, Katherine A. Grant-Young, John G. Houston, Harold N. Weller, Cullen L. Cavallaro, R. Thomas Swann, Michael A. Poss, Martin M. Echols
Publikováno v:
Journal of Combinatorial Chemistry. 8:664-669
The application of parallel synthesis to lead optimization programs in drug discovery has been an ongoing challenge since the first reports of library synthesis. A number of approaches to the application of parallel array synthesis to lead optimizati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfac5969bf582a01ce8f85c011e56175
https://doi.org/10.1021/cc050164h
https://doi.org/10.1021/cc050164h
Autor:
Shuanghua, Hu, Yazhong, Huang, Yong-Jin, Wu, Huan, He, Katherine A, Grant-Young, Robert L, Bertekap, Valerie, Whiterock, Patrick, Brassil, Kimberley, Lentz, Prasanna, Sivaprakasam, David R, Langley, Ryan S, Westphal, Paul M, Scola
Publikováno v:
Bioorganicmedicinal chemistry. 22(5)
Comprehensive structure activity relationship (SAR) studies were conducted on a focused screening hit, 2-(methylthio)-3-(phenylsulfonyl)-4H-pyrido[1,2-a]pyrimidin-4-imine (1, IC50: 4.0 nM), as 5-HT6 selective antagonists. Activity was improved some 2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::513af1c2e3df47726118c0f0fb929ff8
https://pubmed.ncbi.nlm.nih.gov/24495863
https://pubmed.ncbi.nlm.nih.gov/24495863
Autor:
C. David Weaver, Shuanghua Hu, Tracey Fiedler, Robert G. Gentles, Michael A. Poss, Katherine A. Grant-Young, Nicholas J. Lodge, C. J. Andres, David G. Harden, Ronald J. Knox, Yazhong Huang
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(19)
An initial SAR study on a series of apamin-displacing 2-aminothiazole K(Ca)2 channel blockers is described. Potent inhibitors such as N-(4-methylpyridin-2-yl)-4-(pyridin-2-yl)thiazol-2-amine (13) are disclosed, and for select members of the series, t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ad4d70227e7dcf6b1277c2291110a61
https://pubmed.ncbi.nlm.nih.gov/18774291
https://pubmed.ncbi.nlm.nih.gov/18774291