Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Katherine A. Edmonds"'
Autor:
Claire C. Mammoser, Brynn E. LeMasters, Sydney G. Edwards, Emma M. McRae, M. Hunter Mullins, Yiqi Wang, Nicholas M. Garcia, Katherine A. Edmonds, David P. Giedroc, Megan C. Thielges
Publikováno v:
Communications Chemistry, Vol 6, Iss 1, Pp 1-9 (2023)
Abstract Blue copper proteins are models for illustrating how proteins tune metal properties. Nevertheless, the mechanisms by which the protein controls the metal site remain to be fully elucidated. A hindrance is that the closed shell Cu(I) site is
Externí odkaz:
https://doaj.org/article/f73a1aa8abd44131a24ab020e3fde38c
Autor:
Yifan Zhang, Giovanni Gonzalez-Gutierrez, Katherine A. Legg, Brenna J. C. Walsh, Cristian M. Pis Diez, Katherine A. Edmonds, David P. Giedroc
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The extent to which human bacterial pathogens broadly utilize ergothioneine as an antioxidant is unknown. Here, authors describe the discovery of a specific transporter for ergothioneine in a respiratory pathogen that is highly conserved among Firmic
Externí odkaz:
https://doaj.org/article/020e1d9700b54130b84870a80838af9c
Autor:
Brenna J. C. Walsh, Sofia Soares Costa, Katherine A. Edmonds, Jonathan C. Trinidad, Federico M. Issoglio, José A. Brito, David P. Giedroc
Publikováno v:
Antioxidants, Vol 11, Iss 8, p 1607 (2022)
Hydrogen sulfide (H2S) is implicated as a cytoprotective agent that bacteria employ in response to host-induced stressors, such as oxidative stress and antibiotics. The physiological benefits often attributed to H2S, however, are likely a result of d
Externí odkaz:
https://doaj.org/article/b80dede8359641e39486f883ee6e0b87
Autor:
Brenna J. C. Walsh, Jiefei Wang, Katherine A. Edmonds, Lauren D. Palmer, Yixiang Zhang, Jonathan C. Trinidad, Eric P. Skaar, David P. Giedroc
Publikováno v:
mBio, Vol 11, Iss 3 (2020)
ABSTRACT Acinetobacter baumannii is an opportunistic nosocomial pathogen that is the causative agent of several serious infections in humans, including pneumonia, sepsis, and wound and burn infections. A. baumannii is also capable of forming proteina
Externí odkaz:
https://doaj.org/article/9c05a8f948d04b15b84e77a4280b07b8
Autor:
Britta E. Rued, Martín Alcorlo, Katherine A. Edmonds, Siseth Martínez-Caballero, Daniel Straume, Yue Fu, Kevin E. Bruce, Hongwei Wu, Leiv S. Håvarstein, Juan A. Hermoso, Malcolm E. Winkler, David P. Giedroc
Publikováno v:
mBio, Vol 10, Iss 1 (2019)
ABSTRACT Streptococcus pneumoniae is a leading killer of infants and immunocompromised adults and has become increasingly resistant to major antibiotics. Therefore, the development of new antibiotic strategies is desperately needed. Targeting bacteri
Externí odkaz:
https://doaj.org/article/28bda687b8f04f1b9f23af1eaef5cc27
Autor:
Hui Peng, Jiangchuan Shen, Katherine A. Edmonds, Justin L. Luebke, Anne K. Hickey, Lauren D. Palmer, Feng-Ming James Chang, Kevin A. Bruce, Thomas E. Kehl-Fie, Eric P. Skaar, David P. Giedroc
Publikováno v:
mSphere, Vol 2, Iss 3 (2017)
ABSTRACT Staphylococcus aureus is a commensal human pathogen and a major cause of nosocomial infections. As gaseous signaling molecules, endogenous hydrogen sulfide (H2S) and nitric oxide (NO·) protect S. aureus from antibiotic stress synergisticall
Externí odkaz:
https://doaj.org/article/60c8556789154f8cabe92ef3914e72d7
Publikováno v:
Biomol NMR Assign
Streptococcus pneumoniae is a Gram-positive human pathogen that causes millions of infections worldwide with an increasing occurrence of antibiotic resistance. Iron acquisition is essential for its survival and virulence, especially under host-impose
Autor:
Katherine A. Edmonds, Mauro Bringas, Justin L. Luebke, Giovanni Gonzalez-Gutierrez, Daiana A. Capdevila, David P. Giedroc, Joseph N. Fakhoury, Yifan Zhang
Publikováno v:
Nucleic Acids Research
CstR is a persulfide-sensing member of the functionally diverse copper-sensitive operon repressor (CsoR) superfamily. While CstR regulates the bacterial response to hydrogen sulfide (H2S) and more oxidized reactive sulfur species (RSS) in Gram-positi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00ef76267c71526941fa931fce31b477
https://doi.org/10.1101/2021.07.25.453692
https://doi.org/10.1101/2021.07.25.453692
Publikováno v:
Metallomics
Transition metal homeostasis ensures that cells and organisms obtain sufficient metal to meet cellular demand while dispensing with any excess so as to avoid toxicity. In bacteria, zinc restriction induces the expression of one or more Zur (zinc-upta
Publikováno v:
Journal of Biological Chemistry. 298:102046
Streptococcus pneumoniae (pneumococcus) is a Gram-positive commensal and human respiratory pathogen. How this bacterium satisfies its nutritional iron (Fe) requirement in the context of endogenously produced hydrogen peroxide is not well understood.