Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Katherine A. B. Kellett"'
Autor:
Isobel J Whitehouse, Deborah Brown, Herbert Baybutt, Abigail B Diack, Katherine A B Kellett, Pedro Piccardo, Jean C Manson, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 11, Iss 7, p e0159119 (2016)
The cellular prion protein (PrPC) has been proposed to play an important role in the pathogenesis of Alzheimer's disease. In cellular models PrPC inhibited the action of the β-secretase BACE1 on wild type amyloid precursor protein resulting in a red
Externí odkaz:
https://doaj.org/article/661eb766a5da451a8aa047e01b1089fe
Publikováno v:
Neuronal Signaling
The neurovascular unit (NVU), consisting of neurons, glial cells, vascular cells (endothelial cells, pericytes and vascular smooth muscle cells (VSMCs)) together with the surrounding extracellular matrix (ECM), is an important interface between the p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cdef93861431567d0da4eab9ac3b703b
https://doi.org/10.1042/ns20210027
https://doi.org/10.1042/ns20210027
Autor:
Catherine B. Lawrence, Lana Papafilippou, James Eales, Marilena Hadjidemetriou, Kostas Kostarelos, Nigel M. Hooper, Jack Rivers-Auty, Katherine A. B. Kellett
Publikováno v:
Hadjidemetriou, M, Rivers-Auty, J, Papafilippou, L, Eales, J, Kellett, K A B, Hooper, N M, Lawrence, C B & Kostarelos, K 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer's Disease ', ACS Nano, vol. 15, no. 4, pp. 7357-7369 . https://doi.org/10.1021/acsnano.1c00658
ACS Nano
Papafilippou, T A, Hadjidemetriou, M, Kostarelos, K, Rivers-Auty, J, Hooper, N, Lawrence, C B & Eales, J 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease ', ACS Nano, pp. 7357–7369 . https://doi.org/10.1021/acsnano.1c00658
ACS Nano
Papafilippou, T A, Hadjidemetriou, M, Kostarelos, K, Rivers-Auty, J, Hooper, N, Lawrence, C B & Eales, J 2021, ' Nanoparticle-Enabled Enrichment of Longitudinal Blood Proteomic Fingerprints in Alzheimer’s Disease ', ACS Nano, pp. 7357–7369 . https://doi.org/10.1021/acsnano.1c00658
Blood-circulating biomarkers have the potential to detect Alzheimer's disease (AD) pathology before clinical symptoms emerge and to improve the outcomes of clinical trials for disease-modifying therapies. Despite recent advances in understanding conc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd859d253447b068f05de39842ece6e3
https://doi.org/10.1021/acsnano.1c00658
https://doi.org/10.1021/acsnano.1c00658
Autor:
Isobel J Whitehouse, J Scott Miners, Elizabeth B C Glennon, Patrick G Kehoe, Seth Love, Katherine A B Kellett, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e59554 (2013)
The cellular prion protein (PrP(C)) has been implicated in the development of Alzheimer's disease (AD). PrP(C) decreases amyloid-β (Aβ) production, which is involved in AD pathogenesis, by inhibiting β-secretase (BACE1) activity. Contactin 5 (CNTN
Externí odkaz:
https://doaj.org/article/ee16e95ab5754226969dbd39ff64f1cc
Autor:
Elizabeth B C Glennon, Isobel J Whitehouse, J Scott Miners, Patrick G Kehoe, Seth Love, Katherine A B Kellett, Nigel M Hooper
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e78806 (2013)
Bridging integrator 1 (BIN1) has been implicated in sporadic Alzheimer's disease (AD) by a number of genome wide association studies (GWAS) in a variety of populations. Here we measured BIN1 in frontal cortex samples from 24 sporadic AD and 24 age-ma
Externí odkaz:
https://doaj.org/article/ef52b105705747f99d93a0f22f859fb6
Publikováno v:
Neurochemical Research
Rowland, H, Hooper, N & Kellett, K 2018, ' Modelling Sporadic Alzheimer’s Disease using Induced Pluripotent Stem Cells ', Neurochemical research . https://doi.org/10.1007/s11064-018-2663-z
Rowland, H, Hooper, N & Kellett, K 2018, ' Modelling Sporadic Alzheimer’s Disease using Induced Pluripotent Stem Cells ', Neurochemical research . https://doi.org/10.1007/s11064-018-2663-z
Developing cellular models of sporadic Alzheimer’s disease (sAD) is challenging due to the unknown initiator of disease onset and the slow disease progression that takes many years to develop in vivo. The use of human induced pluripotent stem cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4453cbeead529ae123ac989c1b0fe7f1
https://doi.org/10.1007/s11064-018-2663-z
https://doi.org/10.1007/s11064-018-2663-z
Autor:
Katherine A. B. Kellett, Sikha Saha, Nadira Yuldasheva, Alasdair R. Pickles, Sabah Khan, Trevor F.C. Batten
Publikováno v:
Neurochemistry International. 118:134-144
Cerebral ischemia is known to be a major cause of death and the later development of Alzheimer's disease and vascular dementia. However, ischemia induced cellular damage that initiates these diseases remain poorly understood. This is primarily due to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3417f83df5d5940ff5d44e111fdac467
https://doi.org/10.1016/j.neuint.2018.04.004
https://doi.org/10.1016/j.neuint.2018.04.004
Publikováno v:
Andrew, R J, Kellett, K, Thinakaran, G & Hooper, N 2016, ' A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis ', Journal of Biological Chemistry, vol. 291, pp. 19235-19244 . https://doi.org/10.1074/jbc.R116.746032
Proteolysis of the amyloid precursor protein (APP) liberates various fragments including the proposed initiator of Alzheimer disease-associated dysfunctions, amyloid-β. However, recent evidence suggests that the accepted view of APP proteolysis by t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d80149f838b233450cf70d8de7d546e0
https://doi.org/10.1074/jbc.r116.746032
https://doi.org/10.1074/jbc.r116.746032
Autor:
Daniel S. Greenspan, Kate Fisher, Sreemoti Banerjee, Catherine B. Lawrence, Carolyn D. Jackson, Katherine A. B. Kellett, Christopher J. Duff, Nobuyo Maeda, Nigel M. Hooper, Robert J. Andrew
Publikováno v:
Scientific Reports
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
Banerjee, S, Andrew, R J, Duff, C J, Fisher, K, Jackson, C D, Lawrence, C B, Maeda, N, Greenspan, D S, Kellett, K & Hooper, N 2019, ' Proteolysis of the low density lipoprotein receptor by bone morphogenetic protein-1 regulates cellular cholesterol uptake ', Scientific Reports . https://doi.org/10.1038/s41598-019-47814-0
Scientific Reports, Vol 9, Iss 1, Pp 1-14 (2019)
The development of cardiovascular disease is intimately linked to elevated levels of low-density lipoprotein (LDL) cholesterol in the blood. Hepatic LDL receptor (LDLR) levels regulate the amount of plasma LDL. We identified the secreted zinc metallo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ae9398889d0b645d0a6175f4006391d
https://pubmed.ncbi.nlm.nih.gov/32042031
https://pubmed.ncbi.nlm.nih.gov/32042031
Autor:
Satyan Chintawar, Sally A. Cowley, Helen A. Rowland, Heledd H. Jarosz-Griffiths, Nigel M. Hooper, Gareth Howell, M. Zameel Cader, Katherine A. B. Kellett, Jennifer Baron, Kate Fisher, Nicola J. Corbett, Alys C. Jones
Publikováno v:
The Journal of Biological Chemistry
The cellular prion protein (PrPC) is a key neuronal receptor for β-amyloid oligomers (AβO), mediating their neurotoxicity, which contributes to the neurodegeneration in Alzheimer's disease (AD). Similarly to the amyloid precursor protein (APP), PrP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0adba82d80ec3a0a33511ad63a991806
https://pubmed.ncbi.nlm.nih.gov/30872401
https://pubmed.ncbi.nlm.nih.gov/30872401