Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Katherine A. Abrahams"'
Publikováno v:
The Cell Surface, Vol 11, Iss , Pp 100122- (2024)
Externí odkaz:
https://doaj.org/article/6f06df23223b4f97a50cfd5ef2d34014
DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid
Autor:
Katherine A. Abrahams, Sarah M. Batt, Sudagar S. Gurcha, Natacha Veerapen, Ghader Bashiri, Gurdyal S. Besra
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Mycobacterium tuberculosis is one of the global leading causes of death due to a single infectious agent. Pretomanid and delamanid are new antitubercular agents that have progressed through the drug discovery pipeline. These compounds are bi
Externí odkaz:
https://doaj.org/article/40bdd0a34d744b8786bc6a3db7dc1740
Autor:
Katherine A. Abrahams, Wei Hu, Gang Li, Yu Lu, Emily J. Richardson, Nicholas J. Loman, Haihong Huang, Gurdyal S. Besra
Publikováno v:
The Cell Surface, Vol 6, Iss , Pp 100040- (2020)
The emergence and perseverance of drug resistant strains of Mycobacterium tuberculosis (Mtb) ensures that drug discovery efforts remain at the forefront of tuberculosis research. There are numerous different approaches that can be employed to lead to
Externí odkaz:
https://doaj.org/article/763a2eec32d146b686041feaf3aa66fd
Autor:
Katherine A. Abrahams, Chun-wa Chung, Sonja Ghidelli-Disse, Joaquín Rullas, María José Rebollo-López, Sudagar S. Gurcha, Jonathan A. G. Cox, Alfonso Mendoza, Elena Jiménez-Navarro, María Santos Martínez-Martínez, Margarete Neu, Anthony Shillings, Paul Homes, Argyrides Argyrou, Ruth Casanueva, Nicholas J. Loman, Patrick J. Moynihan, Joël Lelièvre, Carolyn Selenski, Matthew Axtman, Laurent Kremer, Marcus Bantscheff, Iñigo Angulo-Barturen, Mónica Cacho Izquierdo, Nicholas C. Cammack, Gerard Drewes, Lluis Ballell, David Barros, Gurdyal S. Besra, Robert H. Bates
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Screens for bactericidal compounds have resulted in promising anti-tubercular hits. Here, the authors analyse in detail the target of an indazole sulfonamide (GSK3011724A), and find that it has a different mode of inhibition compared to other Kas inh
Externí odkaz:
https://doaj.org/article/98e2a1212a5248b996b2c2ff78fce60e
Autor:
Eric L. Nuermberger, Maria Santos Martínez-Martínez, Olalla Sanz, Beatriz Urones, Jorge Esquivias, Heena Soni, Rokeya Tasneen, Sandeep Tyagi, Si-Yang Li, Paul J. Converse, Helena I. Boshoff, Gregory T. Robertson, Gurdyal S. Besra, Katherine A. Abrahams, Anna M. Upton, Khisimuzi Mdluli, Gary W. Boyle, Sam Turner, Nader Fotouhi, Nicholas C. Cammack, Juan Miguel Siles, Marta Alonso, Jaime Escribano, Joel Lelievre, Joaquin Rullas-Trincado, Esther Pérez-Herrán, Robert H. Bates, Gareth Maher-Edwards, David Barros, Lluís Ballell, Elena Jiménez
Publikováno v:
Antimicrobial Agents and Chemotherapy. 66
As a result of a high-throughput compound screening campaign using Mycobacterium tuberculosis -infected macrophages, a new drug candidate for the treatment of tuberculosis has been identified. GSK2556286 inhibits growth within human macrophages (50%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a0efb69d85ba133e740da0ce522724b
https://doi.org/10.1128/aac.00132-22
https://doi.org/10.1128/aac.00132-22
Autor:
Gurdyal S. Besra, Katherine A. Abrahams, Dirk Schnappinger, Christopher M. Sassetti, K. G. Papavinasasundaram, Alfonso Mendoza-Losana, Jonathan F. Bean, Wei Li, Shipra Grover, Mary Jackson, Esther Pérez-Herrán, Curtis A. Engelhart
Publikováno v:
ACS Infectious Diseases. 7:141-152
MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a966833f20a33bcbf625539df5d6f440
https://doi.org/10.1021/acsinfecdis.0c00675
https://doi.org/10.1021/acsinfecdis.0c00675
Autor:
Shipra Grover, Curtis A. Engelhart, Esther Perez‐Herran, Divya Tiwari, Wei Li, Katherine A. Abrahams, Kadamba Papavinasasundaram, James M. Bean, Christopher M. Sassetti, Alfonso Mendoza‐Losana, Gurdyal S. Besra, Mary Jackson, Courtney Aldrich, Dirk Schnappinger
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::aaf2253f70ddfb3e9622a22b5db041f9
https://doi.org/10.1096/fasebj.2022.36.s1.l7723
https://doi.org/10.1096/fasebj.2022.36.s1.l7723
Publikováno v:
RSC Medicinal Chemistry
Mycobacterium tuberculosis is the causative pathogen of the pulmonary disease tuberculosis. Despite the availability of effective treatment programs, there is a global pursuit of new anti-tubercular agents to respond to the developing threat of drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91139398adc938d7d868f22cf93c28ae
http://europepmc.org/articles/PMC8126887
http://europepmc.org/articles/PMC8126887
Autor:
Shipra, Grover, Curtis A, Engelhart, Esther, Pérez-Herrán, Wei, Li, Katherine A, Abrahams, Kadamba, Papavinasasundaram, James M, Bean, Christopher M, Sassetti, Alfonso, Mendoza-Losana, Gurdyal S, Besra, Mary, Jackson, Dirk, Schnappinger
Publikováno v:
ACS Infectious Diseases
MmpL3, an essential mycolate transporter in the inner membrane of Mycobacterium tuberculosis (Mtb), has been identified as a target of multiple, chemically diverse antitubercular drugs. However, several of these molecules seem to have secondary targe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::402cbf55036d921771fbf33d979568d9
https://pubmed.ncbi.nlm.nih.gov/33319550
https://pubmed.ncbi.nlm.nih.gov/33319550
Autor:
Yu Lu, Nicholas J. Loman, Gang Li, Emily J. Richardson, Haihong Huang, Gurdyal S. Besra, Katherine A. Abrahams, Wei Hu
Publikováno v:
The Cell Surface, Vol 6, Iss, Pp 100040-(2020)
The Cell Surface
The Cell Surface
The emergence and perseverance of drug resistant strains of Mycobacterium tuberculosis (Mtb) ensures that drug discovery efforts remain at the forefront of tuberculosis research. There are numerous different approaches that can be employed to lead to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7ac5c09853ca1994e1a75464f2b5339
http://www.sciencedirect.com/science/article/pii/S2468233020300074
http://www.sciencedirect.com/science/article/pii/S2468233020300074