Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Katherine A B Knostman"'
Autor:
Anne E Boyer, Maribel Gallegos-Candela, Renato C Lins, Maria I Solano, Adrian R Woolfitt, John S Lee, Daniel C Sanford, Katherine A B Knostman, Conrad P Quinn, Alex R Hoffmaster, James L Pirkle, John R Barr
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010735 (2022)
Inhalation anthrax has three clinical stages: early-prodromal, intermediate-progressive, and late-fulminant. We report the comprehensive characterization of anthrax toxins, including total protective antigen (PA), total lethal factor (LF), total edem
Externí odkaz:
https://doaj.org/article/e29878e29f4a4d4bab71c0fda04880e9
Autor:
Katherine A. B. Knostman, Brian M. Roche, Edward J. Wakayama, Michael A. Hawk, Zhenxu J. Ma, Kim Henderson, Carol L. Sabourin, Patrick J. Sabourin, Glenn D. Ritchie, Claire M. Matthews
Publikováno v:
International Journal of Toxicology. 35:604-615
The Food and Drug Administration Animal Rule requires evaluation of cardiovascular and central nervous system (CNS) effects of new therapeutics. To characterize an adult and juvenile mouse model, neurobehavioral and cardiovascular effects and patholo
Autor:
Brandon Wood, R. Brandon Borders, John Ross, Seth Gibbs, Amir Abdulalil, Anthony J. Skowronek, Jeremy Smith, Katherine A. B. Knostman, Jay Bailey, Kim Henderson, Tom Vinci, Michael V. Knopp, Brian Roche
Publikováno v:
Journal of pharmacological and toxicological methods. 94(Pt 2)
The isolated rat heart (Langendorff) assay combined with NMR spectroscopy and histology were used to elucidate functional, metabolic, and histological signs of cardiotoxicity resulting from acute exposure to clinically relevant concentrations of doxo
Autor:
Jennifer A. Price, Herbert S. Bresler, Katherine A. B. Knostman, Manjula D. Kasoji, Morgan Q. S. Wendling, James P. Long, Eric M. Vela
Publikováno v:
Journal of Medical Microbiology. 63:1131-1142
Influenza virus infections in humans remain a healthcare concern, and the need for vaccines, therapeutics and prophylactics remains a high priority. Understanding the molecular events associated with influenza-virus-induced pathology may lead to the
Autor:
Lisa N. Henning, Gabriel T. Meister, Bryan D. Ray, Kevin P. Tordoff, Gregory V. Stark, Jason E. Comer, Katherine A. B. Knostman
Publikováno v:
Clinical and Vaccine Immunology. 19:1765-1775
Appropriate animal models are required to test medical countermeasures to bioterrorist threats. To that end, we characterized a nonhuman primate (NHP) inhalational anthrax therapeutic model for use in testing anthrax therapeutic medical countermeasur
Autor:
Matthew D. Stout, Milton R. Hejtmancik, Katherine A. B. Knostman, Michelle C. Cora, Paul M. D. Foster, Retha R. Newbold, Kristine L. Witt, Michael J. Ryan, Molly Vallant, Courtney A. Granville, Minerva Mercado-Feliciano, Cynthia Smith, Laurene M. Fomby
Publikováno v:
Toxicology and Applied Pharmacology. 263:138-147
Black cohosh rhizome (Actaea racemosa) is used as a remedy for pain and gynecological ailments; modern preparations are commonly sold as ethanolic extracts available as dietary supplements. Black cohosh was nominated to the National Toxicology Progra
Autor:
Robert Segal, Michael C. Babin, Mark R. Perry, Katherine A. B. Knostman, Jennifer L. Plahovinsak
Publikováno v:
Inhalation toxicology. 27(14)
Phosgene's primary mode of action is as a pulmonary irritant characterized by its early latent phase where life-threatening, non-cardiogenic pulmonary edema is typically observed 6-24 h post-exposure.To develop an inhaled phosgene acute lung injury (
Autor:
James O. Peggins, Christa Zwayer, Michael J. Ryan, Jerry D. Johnson, Joseph E. Tomaszewski, Daniel Johnson, Jennifer R. Grandis, Patricia J. Tosca, Patricia C. Giclas, Robert L. Ferris, William E. Gooding, Sufi M. Thomas, Timothy P McMurray, Malabika Sen, Changyou Li, Katherine A. B. Knostman, Michael S. Leibowitz
Publikováno v:
Cancer Chemotherapy and Pharmacology. 63:983-995
STAT3 overexpression has been detected in several cancers including head and neck squamous cell carcinoma (HNSCC). Previous studies using intratumoral administration of a STAT3 decoy oligonucleotide that abrogates STAT3-mediated gene transcription in
Autor:
David A. Fisher, Pauline A. Vales, Ashley B. Robertson, John E. Bigger, Katherine A. B. Knostman, Roy E. Barnewall
Publikováno v:
Frontiers in Cellular and Infection Microbiology
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
Frontiers in Cellular and Infection Microbiology, Vol 2 (2012)
An inhalation exposure system was characterized to deliver aerosolized monkeypox virus (MPXV), and a nonhuman primate (NHP) inhalation monkeypox model was developed in cynomologus macaques. A head-only aerosol exposure system was characterized, and t
Autor:
R. Stammen, Jennifer Garver, Jason M. Mott, Lela Johnson Vela, Katherine A. B. Knostman, Eric M. Vela, Richard L. Warren
Publikováno v:
Antiviral research. 87(3)
Arenaviruses are rodent-borne negative strand RNA viruses and infection of these viruses in humans may result in disease and hemorrhagic fever. To date, supportive care, ribavirin, and in some cases immune plasma remain the foremost treatment options