Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Katherine A. McArthur"'
Publikováno v:
Clinical Interventions in Aging
As stroke care has developed, there has been a need to robustly assess the efficacy of interventions both at the level of the individual stroke survivor and in the context of clinical trials. To describe stroke-survivor recovery meaningfully, more so
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6cbc669c4a8c27783d43a8c1f6effa8
http://europepmc.org/articles/PMC3578502
http://europepmc.org/articles/PMC3578502
Autor:
Venkat R. Macherla, Katherine A. McArthur, Barbara C. M. Potts, Rama Rao Manam, Michael Groll
Publikováno v:
Journal of Medicinal Chemistry. 52:5420-5428
Many marketed drugs contain fluorine, reflecting its ability to modulate a variety of biological responses. The unique 20S proteasome inhibition profile of fluorosalinosporamide compared to chlorinated anticancer agent salinosporamide A (NPI-0052) is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a4a9b704fd993b8cf996a1a138e9c31
https://doi.org/10.1021/jm900559x
https://doi.org/10.1021/jm900559x
Autor:
Ginger Tsueng, Jianlin Xu, Scott S Mitchell, Barbara C. M. Potts, Katherine A. McArthur, Kin S. Lam
Publikováno v:
The Journal of Antibiotics. 60:13-19
We examined the effects of halogens on the production of salinosporamide A (NPI-0052) by the obligate marine actinomycete Salinispora tropica NPS465, specifically the production of analogs containing halogens other than chlorine. Adding NaF, NaBr and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6251ce366f3e451896c1f6109d721ed3
https://doi.org/10.1038/ja.2007.2
https://doi.org/10.1038/ja.2007.2
Autor:
Ta-Hsiang Chao, Bruno Hagenbuch, Saskia T. C. Neuteboom, Rama Rao Manam, Barbara C. M. Potts, Amanda Obaidat, G. Kenneth Lloyd, S. J. Enna, Jeffrey Weiss, Katherine A. McArthur, Brett Wahlgren, Michael A. Palladino, Venkat R. Macherla
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 337(2)
The present study was undertaken to compare the cellular transport characteristics of [(3)H]NPI-0052 (1R,4R,5S)-4-(2-chloroethyl)-1-((S)-((S)-cyclohex-2-enyl)(hydroxy)methyl)-5-methyl-6-oxa-2-azabicyclo[3.2.0]heptane-3,7-dione (marizomib; salinospora
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dece95f1e2609f46b7c90f71b5745e96
https://pubmed.ncbi.nlm.nih.gov/21303921
https://pubmed.ncbi.nlm.nih.gov/21303921
Autor:
Saskia Theodora Cornelia Neuteboom, Katherine A McArthur, Vito J Palombella, Michael Groll, Ta-Hsiang Chao, G Kenneth Lloyd, Janid A. Ali, Barbara Christine Potts, Rama Rao Manam, Venkat R Macherla, Michael A Palladino, Jeffrey Weiss
Publikováno v:
Journal of medicinal chemistry. 51(21)
Salinosporamide A ( 1 (NPI-0052)) is a potent, monochlorinated 20S proteasome inhibitor in clinical trials for the treatment of cancer. To elucidate the role of the chlorine leaving group (LG), we synthesized analogues with a range of LG potentials a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e220dba139a3af7c9357d5c26cc96432
https://pubmed.ncbi.nlm.nih.gov/18939815
https://pubmed.ncbi.nlm.nih.gov/18939815
Autor:
Barbara C. M. Potts, Arnold L. Rheingold, Scott S Mitchell, Ginger Tsueng, Katherine A. McArthur, Kin S. Lam, Jennifer Grodberg, Donald J. White
Publikováno v:
Journal of natural products. 71(10)
A series of chlorinated bisindole pyrroles, lynamicins A-E (1-5), was discovered from a novel marine actinomycete, NPS12745, which was isolated from a marine sediment collected off the coast of San Diego, California. Close to full length 16S rRNA seq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e4a1906fbf58b3b7a2868018eaeb494
https://pubmed.ncbi.nlm.nih.gov/18842058
https://pubmed.ncbi.nlm.nih.gov/18842058
Autor:
Venkat R. Macherla, Rama Rao Manam, Barbara Christine Potts, Katherine A. McArthur, Taotao Ling
Publikováno v:
Organic letters. 9(12)
A novel enantioselective total synthesis of 20S proteasome inhibitor Salinosporamide A (NPI-0052; 1) is presented. Key features include intramolecular aldol cyclization of 6 to simultaneously generate the three chiral centers of advanced intermediate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a133b5e6d0bbb19f7ee06d2d5f49a67
https://pubmed.ncbi.nlm.nih.gov/17497868
https://pubmed.ncbi.nlm.nih.gov/17497868
Publikováno v:
Applied microbiology and biotechnology. 75(5)
Feeding sodium butyrate (0.25-1 mg/ml) to cultures of Salinispora tropica NPS21184 enhanced the production of salinosporamide B (NPI-0047) by 319% while inhibiting the production of salinosporamide A (NPI-0052) by 26%. Liquid chromatography mass spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17dd457034e63aafae0507d3d0878b9d
https://pubmed.ncbi.nlm.nih.gov/17340108
https://pubmed.ncbi.nlm.nih.gov/17340108
Publikováno v:
Journal of Medicinal Chemistry; Sep2009, Vol. 52 Issue 17, p5420-5428, 9p
Autor:
Rama Rao Manam, Katherine A. McArthur, Ta-Hsiang Chao, Jeffrey Weiss, Janid A. Ali, Vito J. Palombella, Michael Groll, G. Kenneth Lloyd, Michael A. Palladino, Saskia T. C. Neuteboom, Venkat R. Macherla, Barbara C. M. Potts
Publikováno v:
Journal of Medicinal Chemistry; Oct2008, Vol. 51 Issue 21, p6711-6724, 14p