Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Katherine A. Hinchliffe"'
Autor:
Francesca Oltrabella, Grzegorz Pietka, Irene Barinaga-Rementeria Ramirez, Aleksandr Mironov, Toby Starborg, Iain A Drummond, Katherine A Hinchliffe, Martin Lowe
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005058 (2015)
Lowe syndrome and Dent-2 disease are caused by mutation of the inositol 5-phosphatase OCRL1. Despite our increased understanding of the cellular functions of OCRL1, the underlying basis for the renal tubulopathy seen in both human disorders, of which
Externí odkaz:
https://doaj.org/article/89df8565e2f344eda413585465c67277
Publikováno v:
Pflügers Archiv - European Journal of Physiology. 462:723-732
The phosphoinositide phospholipid PtdIns5P has previously been implicated in insulin-stimulated translocation of the glucose transporter GLUT4 into the plasma membrane of adipocytes, but its potential role in glucose transport in muscle has not been
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c30d6dad98aa1081d9c4af6f8aa1763
https://doi.org/10.1007/s00424-011-1008-4
https://doi.org/10.1007/s00424-011-1008-4
Publikováno v:
Biochemical Society Symposia. 74:149-159
The regulation of the synthesis of PtdIns(4,5)P2 is emerging as being as complex as we might expect from the multi-functional nature of this lipid. In the present chapter we focus on one aspect of inositide metabolism, which is the functions of the T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2b43d4800a68c671435e9ba61f81d1c1
https://doi.org/10.1042/bss2007c14
https://doi.org/10.1042/bss2007c14
Publikováno v:
Cellular Signalling. 18:1906-1913
The type II PIP kinases phosphorylate the poorly understood inositol lipid PtdIns5P, producing the multi-functional lipid product PtdIns(4,5)P(2). To investigate the regulation of these enzymes by phosphorylation, we partially purified a protein kina
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f97a64d1817fef10057a68bd1b445092
https://doi.org/10.1016/j.cellsig.2006.02.005
https://doi.org/10.1016/j.cellsig.2006.02.005
Activation of extracellular signal-regulated protein kinase 5 downregulates FasL upon osmotic stress
Autor:
Xin Wang, Katherine A. Hinchliffe, Raymond P. Boot-Handford, Andrew C Robinson, R Khosravi-Far, Lynnette Knowles, Cathy Tournier, Katherine G. Finegan
Publikováno v:
Cell Death & Differentiation. 13:2099-2108
Extracellular signal-regulated protein kinase (ERK) 5 is a mitogen-activated protein kinase (MAPK) that is activated by dual phosphorylation via a unique MAPK/ERK kinase 5, MEK5. The physiological importance of this signaling cascade is underscored b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb0f7be4f2c073530a75dd539156010b
https://doi.org/10.1038/sj.cdd.4401969
https://doi.org/10.1038/sj.cdd.4401969
Autor:
Katherine A. Hinchliffe, Robin F. Irvine, Hilary F. Roberts, Jonathan H. Clarke, Andrew J. Letcher
Publikováno v:
FEBS Letters. 579:2868-2872
Phosphatidylinositol 5-phosphate (PtdIns5P) is a relatively recently discovered inositol lipid whose metabolism and functions are not yet clearly understood. We have transfected cells with a number of enzymes that are potentially implicated in the sy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8eeaaae8bb20a0ad2fa433c498c8316f
https://doi.org/10.1016/j.febslet.2005.04.027
https://doi.org/10.1016/j.febslet.2005.04.027
Publikováno v:
Biochemical Journal. 363:563-570
The phosphatidylinositol phosphate kinases (PIPkins) are a family of enzymes involved in regulating levels of several functionally important inositol phospholipids within cells. The PIPkin family is subdivided into three on the basis of substrate spe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::21855a0b3c1371791a970f7973467e31
https://doi.org/10.1042/bj3630563
https://doi.org/10.1042/bj3630563
Autor:
Francesca Oltrabella, Grzegorz Pietka, Irene Barinaga-Rementeria Ramirez, Aleksandr Mironov, Toby Starborg, Iain A Drummond, Katherine A Hinchliffe, Martin Lowe
Publikováno v:
PLoS Genetics
PLoS Genetics, Vol 11, Iss 4, p e1005058 (2015)
PLoS Genetics, Vol 11, Iss 4, p e1005058 (2015)
Lowe syndrome and Dent-2 disease are caused by mutation of the inositol 5-phosphatase OCRL1. Despite our increased understanding of the cellular functions of OCRL1, the underlying basis for the renal tubulopathy seen in both human disorders, of which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::dc4ffc662e85e3dc2a37d0400c95a214
https://pubmed.ncbi.nlm.nih.gov/25838181
https://pubmed.ncbi.nlm.nih.gov/25838181
Publikováno v:
Biochemical Journal. 346:587-591
Type II phosphatidylinositol phosphate kinases (PIPkins) have recently been found to be primarily phosphatidylinositol 5-phosphate 4-kinases, and their physiological role remains unclear. We have previously shown that a Type II PIPkin [isoform(s) unk
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d922f43a45c4cd69796ccf5faed5ab8f
https://doi.org/10.1042/bj3460587
https://doi.org/10.1042/bj3460587
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1436:87-104
The phosphatidylinositolphosphate kinases (PIPkins) are a unique family of enzymes that catalyse the production of phosphorylated inositol lipids. Recent advances have revealed that, due to their ability to utilise a number of different lipid substra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d7d22be77d7b98784cd8e155fa788597
https://doi.org/10.1016/s0005-2760(98)00140-4
https://doi.org/10.1016/s0005-2760(98)00140-4