The Adverse Event Unit (AEU): A novel metric to measure the burden of treatment adverse events

Autor: Michael K. Hehir, Mark Conaway, Eric M. Clark, Denise B. Aronzon, Noah Kolb, Amanda Kolb, Katherine Ruzhansky, Reza Sadjadi, Eduardo A. De Sousa, Ted M. Burns

Publikováno v: PLoS ONE, Vol 17, Iss 2 (2022)

Objective To design a physician and patient derived tool, the Adverse Event Unit (AEU), akin to currency (e.g. U.S. Dollar), to improve AE burden measurement independent of any particular disease or medication class. Patients/Methods A Research Elect

Externí odkaz: https://doaj.org/article/c75e1b7e6f314f7ba451bd7a971707ff

A Phase 3, Open-Label, Multicenter Study To Evaluate Eculizumab In Adolescents With Refractory Generalized Myasthenia Gravis (S5.009)

Autor: John F. Brandsema, Matthew Ginsberg, Hideki Hoshino, Masakazu Mimaki, Satoru Nagata, Vamshi Rao, Katherine Ruzhansky, Niraja Suresh, Emmanuelle Tiongson, Hideo Yamanouchi, Glen Frick, Eden Hicks, Serena Liao, James Howard

Publikováno v: Sunday, April 23.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d4f5343cce691f04b53c74935e636a28
https://doi.org/10.1212/wnl.0000000000202200

Telemedicine visits in myasthenia gravis: Expert guidance and the Myasthenia Gravis Core Exam ( MG‐CE )

Autor: Henry J. Kaminski, Nicte I. Mejia, Gary Cutter, Amanda C. Guidon, Srikanth Muppidi, Katherine Ruzhansky, Jeffrey T. Guptill, Leeann B Burton, Michael K. Hehir, David Post, James F. Howard, Robin Conwit, Richard Nowak

Publikováno v: Muscle Nerve

INTRODUCTION/AIMS: Telemedicine may be particularly well-suited for myasthenia gravis (MG) due to the disorder’s need for specialized care, its hallmark fluctuating muscle weakness, and the potential for increased risk of virus exposure among patie

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100378930904abf25305b7a0047779b4
https://doi.org/10.1002/mus.27260

Thymectomy may not be associated with clinical improvement in MuSK myasthenia gravis

Autor: Richard Nowak, Michael Benatar, Diantha B. Howard, Shane M. Greene, Aditya Kumar, Brian A. Crum, Rachel Beekman, Katherine M Clifford, Michael Pulley, Carolina Barnett, Melissa A. Fellman, Richard J. Barohn, I-Hweii Amy Chen, Katherine Ruzhansky, Shannon M. Laboy, Michael K. Hehir, James F. Howard, Mamatha Pasnoor, Amy Visser, Ted M. Burns, Nicholas Silvestri, Noah Kolb, Mazen M. Dimachkie, Lisa D. Hobson-Webb

Publikováno v: Muscle & Nerve. 59:404-410

Introduction A randomized trial demonstrated benefit from thymectomy in nonthymomatous acetylcholine receptor (AChR)-antibody positive myasthenia gravis (MG). Uncontrolled observational and histologic studies suggest thymectomy may not be efficacious

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::562a78e7711dfc5337f1b15925a150c3
https://doi.org/10.1002/mus.26404

Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT): a multicentre, randomised, placebo-controlled, phase 3 trial

Autor: Lucy Lam, Jiri Pitha, John Vissing, Laura Fionda, Denis Korobko, Michael Pulley, Tony Vangeneugden, Silvia Bonanno, Nobuhiro Ido, Jerrica Farias, Jafar Shabanpour, James Gilchrist, Girolamo Alfieri, Gyorgyi Szabo, Carlayne E. Jackson, Eduardo Ng, Csilla Rozsa, Hans D. Katzberg, Carlo Antozzi, Aleksandra Golenia, Sayaka Ishida, Temur Margania, Andrzej Szczudlik, Richard J. Barohn, Mari Suzuki., Robert Henegar, Kaoru Sakuma, Evanthia Bernitsas, Elena Lapochka, Yukiko Ozawa, Tomihiro Imai, Debbie Hastings, Antonio Guglietta, Benjamin Frishberg, Elena Antipenko, Vera Bril, Stanislav Vohanka, Isela Hernandez, Ivo Bozovic, Ilona Vergunova, Lorenzo Maggi, Andreas Meisel, Ali Malekniazi, Tahseen Mozaffar, Emmanuelle Salort-Campana, Yasmin Camberos, Jan J.G.M. Verschuuren, Masayuki Masuda, Masanori Takahashi, Yoshihiko Okubo, Marek Smilowski, Yasushi Suzuki, Mary Wagoner, Andrew Heim, David Bors, Chiho Watanabe, Fiammetta Vanoli, Antonio Reia, Zubair Quraishi, Omar Jawdat, Makoto Samukawa, Gregory Sahagian, Gedeonne Margo Jakab, Eiichi Nomura, Samantha Colgan, Cindy Benzel, Ayako Mori, Annabel M. Ruiter, Ratna Bharavaju-Sanka, Roman Shakarishvili, Victoria Cannon, Malkova Nadezhda, Tomas Horak, Anna Kostera-Pruszczyk, Eniko Szabo, Emilien Delmont, Alexander Tsiskaridze, Lubna Daniyal, Vidosava Rakocevic Stojanovic, Szilvia Toth, Siegfried Kohler, Iveta Novakova, Katherine Roath, Kazuna Ikeda, Salma Akhter, Claudia Heibutzki, Martijn R. Tannemaat, Marta Pinkosz, Mads Peter Godtfeldt Stemmerik, Chafic Karam, Irys Caristo, Carolyn Paiz, Josef Bednarik, Monika Frasinska, Stefania Morino, Norianne Pimentel, Kanako Minemoto, Rekha Pillai, Linda Wagemaekers, Annelien De Pue, Irina Poverennova, Katerina Reguliova, Jana Junkerova, Angela Marsili, Anne-Marie Peters, Maren Wyckmans, Michaela Tyblova, Debbie Eggleston, Anne Mette Ostergaard Autzen, Takamichi Sugimoto, Kuldeep Kumar Khatri, Niraja Suresh, Jan De Bleecker, Lea Gerischer, Grazyna Zwolinska, Kevin R Keene, Yosuke Onishi, Francesco Saccà, Zaeem A. Siddiqi, Marjolein Van Heur, Jeffrey Statland, Tatiana Romanova, Diana Dimitrova, Stojan Peric, Tomoko Tsuda, Cathy Bailey, Lubov Urtaeva, Lizzie Zafirakos, Katherine Ruzhansky, Tomoya Kubota, Angela Campanella, Nadezhda Kuznetsova, Sarah Jones, Giovanni Antonini, Hiroyuki Murai, Luca Leonardi, Alan R. Berger, Jonathan Baets, Peter Ulrichts, Said R. Beydoun, Michala Jakubikova, Mamatha Pasnoor, James F. Howard, Leila Darki, Katerina Havelkova, Namita Goyal, Akiyuki Uzawa, Tia Nguyen, Miki Takaki, Matteo Garibaldi, Manisha Kak, Ivonne Turner, Aude-Marie Grapperon, Mageda Horakova, Yuebing Li, Ivana Basta, Lech Szczechowski, Shabber Mannan, Aneta Pasko, Caroline Vinck, Riccardo Giossi, Rudolf Mercelis, Ivana Jurajdova, Lesly Welsh, Małgorzata Bilińska, Marek Halas, Dragana Lavrnic, Kimiaki Utsugisawa, Todd Levine, Erik Velasquez, Daisuke Yamamoto, Constantine Farmakidis, John Anthony Morren, Sarah Hoffman, Manisha Chopra, Shingo Konno, Rita Frangiamore, Kelly Jia, Jana Horakova, Anna Melnikova, Piotr Szczudlik, Ali Habib, Giorgia Puorro, Michael D. Weiss, Robert P. Lisak, Hiroyuki Naito, Shahram Attarian, Hiroko Nakamura, Shin Hisahara, Mazen M. Dimachkie, Genya Watanabe, Duaa Jabari, Ekaterina Bulatova, Angela Genge, Makiko Naito, Melissa Currence, Henning Andersen, Katrien De Mey, Kathy de Koning, Yuen T. So, Chiara Pane, Renato Mantegazza, Rebecca Traub, Manato Yasuda, Amy Visser, Dike Remstedt, Yuka Takematsu, Frauke Stascheit, Ayumi Kamei, Tuan Vu, Tulio E. Bertorini, Ludivine Kouton, Neelam Goyal, Flicia Mada, Nizar Chahin, Mihiro Shimizu, Srikanth Muppidi, Erina Sugano

Publikováno v: ADAPT Investigator Study Group 2021, ' Safety, efficacy, and tolerability of efgartigimod in patients with generalised myasthenia gravis (ADAPT) : a multicentre, randomised, placebo-controlled, phase 3 trial ', The Lancet Neurology, vol. 20, no. 7, pp. 526-536 . https://doi.org/10.1016/S1474-4422(21)00159-9
The lancet neurology

Background: There is an unmet need for treatment options for generalised myasthenia gravis that are effective, targeted, well tolerated, and can be used in a broad population of patients. We aimed to assess the safety and efficacy of efgartigimod (AR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2be57499b1a7a7d2e60c700dc07fa4ee
https://pubmed.ncbi.nlm.nih.gov/34426685