Výsledky vyhledávání - "Katherine, Nevin"

Integrated analysis of dermal blister fluid proteomics and genome-wide skin gene expression in systemic sclerosis: an observational study

Autor: Kristina E N Clark, Eszter Csomor, Corrado Campochiaro, Nicholas Galwey, Katherine Nevin, Mary A Morse, Yee Voan Teo, Johannes Freudenberg, Voon H Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M Flint, Christopher P Denton

Publikováno v: The Lancet. Rheumatology. 4(7)

Skin fibrosis is a hallmark feature of systemic sclerosis. Skin biopsy transcriptomics and blister fluid proteomics give insight into the local environment of the skin. We have integrated these modalities with the aim of developing a surrogate for th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b3e00b384b27941b2bda559dde5b9bd
https://pubmed.ncbi.nlm.nih.gov/36404995

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Molecular basis for clinical diversity between autoantibody subsets in diffuse cutaneous systemic sclerosis

Autor: Shaun M. Flint, Corrado Campochiaro, Emma Derrett-Smith, Jennifer Singh, Christopher P. Denton, Nicholas Galwey, Adam Taylor, Katherine Nevin, Kristina Clark, Voon H Ong, Eszter Csomor, Nicolas Wisniacki, Yee Voan Teo, Mary A. Morse

Publikováno v: Annals of the Rheumatic Diseases. 80:1584-1593

ObjectivesClinical heterogeneity is a cardinal feature of systemic sclerosis (SSc). Hallmark SSc autoantibodies are central to diagnosis and associate with distinct patterns of skin-based and organ-based complications. Understanding molecular differe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bfe0b2d30a93d414834be98b5dfacac
https://doi.org/10.1136/annrheumdis-2021-220402

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P229 Integrated analysis of dermal blister fluid proteomics and skin biopsy transcriptomics gives new insight into pathogenesis of systemic sclerosis

Autor: Kristina E. N Clark, Eszter Csomor, Corrado Campochiaro, Yee Voan Teo, Johannes Freudenberg, Katherine Nevin, Mary A Morse, Voon H Ong, Emma Derrett-Smith, Nicolas Wisniacki, Shaun M Flint, Christopher P Denton

Publikováno v: Rheumatology. 61

Background/Aims Suction blister fluid (BF) provides a unique opportunity to analyse the dermal microenvironment of SSc. We utilised an integrated approach to analyse proteomic data from dermal interstitial fluid and genome-wide transcriptomic data fr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60d4f61fe743f489dbec320ac96db257
https://doi.org/10.1093/rheumatology/keac133.228

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P154 High-density proteomic analysis of skin blister fluid and plasma in systemic sclerosis identifies local and systemic differences for key proteins

Autor: Katherine Nevin, Shaun M. Flint, Voon H Ong, Christopher P. Denton, Emma Derrett-Smith, Corrado Campochiaro, Nicolas Wisniacki, Mary A. Morse, Kristina E N Clark, Adam Taylor, Eszter Csomor

Publikováno v: Rheumatology. 60

Background/Aims Simultaneous analysis of multiple proteins in biological fluids offers insight into the pathogenesis of SSc. Here, we report a proteomic analysis of plasma and dermal interstitial fluid in SSc compared with healthy controls (HC). Meth

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::15814c2d8bf7602cadff9f9b8bbbc079
https://doi.org/10.1093/rheumatology/keab247.150

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O18 Integrated molecular analysis of systemic sclerosis skin and blood shows significant differences between major autoantibody subgroups

Autor: Christopher P. Denton, Shaun M. Flint, Adam Taylor, Katherine Nevin, Nicolas Wisniacki, Corrado Campochiaro, Nicholas Galwey, Voon H Ong, Emma Derrett-Smith, Mary A. Morse, Kristina E N Clark, Eszter Csomor

Publikováno v: Rheumatology. 60

Background/Aims The major antinuclear autoantibodies of systemic sclerosis (SSc) associate with different skin score trajectories and risk of internal organ manifestations. To elucidate molecular differences between ANA-defined subgroups, we utilised

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8646ce52ae0ebc78c0a683b5124c21c2
https://doi.org/10.1093/rheumatology/keab246.017

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Safety, pharmacokinetics and pharmacodynamics of a topical SYK inhibitor in cutaneous lupus erythematosus: A double-blind Phase Ib study

Autor: Joerg Wenzel, Sophie Gisbert, Alex Walker, Lars Erwig, Katie Foster, Katherine Nevin, Tanja Schneider-Merck, Heike Carnarius, Margitta Worm, Nicola Williams, Nirav Ratia, Marion C. Dickson, Bao Hoang

Publikováno v: Experimental Dermatology

The immunoregulator spleen tyrosine kinase (SYK) is upregulated in cutaneous lupus erythematosus (CLE). This double‐blind, multicentre, Phase Ib study evaluated the safety, tolerability, pharmacokinetics, pharmacodynamics and clinical efficacy of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::101882ae562739fac74a9a6039cfc474
https://pubmed.ncbi.nlm.nih.gov/33336508

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The role of the oncostatin M/OSM receptor β axis in activating dermal microvascular endothelial cells in systemic sclerosis

Autor: Katherine Nevin, Nicolas Wisniacki, Maria Trojanowska, Lukasz Stawski, Grace Marden, James Wilks, Andreea M. Bujor, Marcin Trojanowski, Qianqian Wan, Maria Feeney

Publikováno v: Arthritis Research & Therapy, Vol 22, Iss 1, Pp 1-14 (2020)
Arthritis Research & Therapy

Background Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum and was recognized as a signific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::268023ef8026580b56f61823b5f14a29
https://doi.org/10.1186/s13075-020-02266-0

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The role of the Oncostatin M/ OSM receptor β axis in activating dermal microvascular endothelial cells in Systemic Sclerosis

Autor: Grace Marden, Qianqian Wan, James Wilks, Katherine Nevin, Maria Feeney, Nicolas Wisniacki, Marcin Trojanowski, Andreea Bujor, Lukasz Stawski, Maria Trojanowska

Background: Scleroderma (SSc) is a rare autoimmune disease characterized by vascular impairment and progressive fibrosis of the skin and other organs. Oncostatin M, a member of the IL-6 family, is elevated in SSc serum and was recognized as a signifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c052f328642238a3698dff3ffd25325d
https://doi.org/10.21203/rs.3.rs-21302/v2

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P154 Stage and subset specific profiles of fibrogenesis highlighted through analysis of serum markers across the scleroderma spectrum

Autor: Eszter Csomor, Nicolas Wisniacki, Emma Derrett-Smith, Shaun M. Flint, Mary A. Morse, Nicholas Galwey, Voon H Ong, Corrado Campochiaro, Katherine Nevin, Christopher P. Denton, Kristina E N Clark

Publikováno v: Rheumatology. 59

Background The striking heterogeneity in skin fibrosis within systemic sclerosis (SSc) is likely to reflect differences between pro- and anti-fibrotic pathways and underlie the spontaneous regression of skin fibrosis observed in late stage diffuse SS

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::addd3abb880e2178eac422b472af9920
https://doi.org/10.1093/rheumatology/keaa111.149

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