Zobrazeno 1 - 10
of 160
pro vyhledávání: '"Katherina Sewald"'
Autor:
Charline Sommer, Stella Marie Reamon-Buettner, Monika Niehof, Christina Beatrix Hildebrand, Armin Braun, Katherina Sewald, Susann Dehmel, Christina Brandenberger
Publikováno v:
Respiratory Research, Vol 25, Iss 1, Pp 1-16 (2024)
Abstract Background Aging is associated with an increased incidence and mortality of Pseudomonas aeruginosa-induced pneumonias. This might be partly due to age-dependent increases in inflammatory mediators, referred to as inflamm-aging and a decline
Externí odkaz:
https://doaj.org/article/533b9c8caabe48f8925d0807efe3488e
Autor:
Michael Rade, Sebastian Böhlen, Vanessa Neuhaus, Dennis Löffler, Conny Blumert, Maximilian Merz, Ulrike Köhl, Susann Dehmel, Katherina Sewald, Kristin Reiche
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-26 (2023)
Abstract Background The coordinated transcriptional regulation of activated T-cells is based on a complex dynamic behavior of signaling networks. Given an external stimulus, T-cell gene expression is characterized by impulse and sustained patterns ov
Externí odkaz:
https://doaj.org/article/ffa3005e33b34cc29a0db10630ff1cf6
Autor:
Luise A. Roser, Christina Sakellariou, Malin Lindstedt, Vanessa Neuhaus, Susann Dehmel, Charline Sommer, Martin Raasch, Thierry Flandre, Sigrid Roesener, Philip Hewitt, Michael J. Parnham, Katherina Sewald, Susanne Schiffmann
Publikováno v:
Journal of Immunotoxicology, Vol 21, Iss sup1 (2024)
AbstractDrug-induced hepatotoxicity constitutes a major reason for non-approval and post-marketing withdrawal of pharmaceuticals. In many cases, preclinical models lack predictive capacity for hepatic damage in humans. A vital concern is the integrat
Externí odkaz:
https://doaj.org/article/a931852d8d8840f494aa1daaaca9c913
Autor:
Jeff Bierwagen, Marie Wiegand, Katrin Laakmann, Olga Danov, Hannah Limburg, Stefanie Muriel Herbel, Thomas Heimerl, Jens Dorna, Danny Jonigk, Christian Preußer, Wilhelm Bertrams, Armin Braun, Katherina Sewald, Leon N. Schulte, Stefan Bauer, Elke Pogge von Strandmann, Eva Böttcher-Friebertshäuser, Bernd Schmeck, Anna Lena Jung
Publikováno v:
Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-15 (2023)
Abstract Gram-negative bacteria naturally secrete nano-sized outer membrane vesicles (OMVs), which are important mediators of communication and pathogenesis. OMV uptake by host cells activates TLR signalling via transported PAMPs. As important reside
Externí odkaz:
https://doaj.org/article/5ab97f46113346758e29ef1c0e67adfd
Autor:
Viktoria Diesendorf, Valeria Roll, Nina Geiger, Sofie Fähr, Helena Obernolte, Katherina Sewald, Jochen Bodem
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
Recently, Tummino et al. reported that 34 compounds, including Chloroquine and Fluoxetine, inhibit SARS-CoV-2 replication by inducing phospholipidosis, although Chloroquine failed to suppress viral replication in Calu-3 cells and patients. In contras
Externí odkaz:
https://doaj.org/article/0cc3735267cd4a38b96cfdbf7bb379a8
Autor:
Christina Hesse, Valerie Beneke, Sebastian Konzok, Claudia Diefenbach, Jannie Marie Bülow Sand, Sarah Rank Rønnow, Morten Asser Karsdal, Danny Jonigk, Katherina Sewald, Armin Braun, Diana Julie Leeming, Lutz Wollin
Publikováno v:
Respiratory Research, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract Background Aberrant extracellular matrix (ECM) deposition and remodelling is important in the disease pathogenesis of pulmonary fibrosis (PF). We characterised neoepitope biomarkers released by ECM turnover in lung tissue from bleomycin-trea
Externí odkaz:
https://doaj.org/article/34a29ce6a5e24095888c0b8a45b0960c
Publikováno v:
BMC Research Notes, Vol 14, Iss 1, Pp 1-8 (2021)
Abstract Objective Human precision cut lung slices (PCLS) are widely used as an ex vivo model system for drug discovery and development of new therapies. PCLS reflect the functional heterogeneity of lung tissue and possess relevant lung cell types. W
Externí odkaz:
https://doaj.org/article/df1941820c4948c99a39aaae49883e04
Autor:
Melissa Zimniak, Luisa Kirschner, Helen Hilpert, Nina Geiger, Olga Danov, Heike Oberwinkler, Maria Steinke, Katherina Sewald, Jürgen Seibel, Jochen Bodem
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-5 (2021)
Abstract To circumvent time-consuming clinical trials, testing whether existing drugs are effective inhibitors of SARS-CoV-2, has led to the discovery of Remdesivir. We decided to follow this path and screened approved medications "off-label" against
Externí odkaz:
https://doaj.org/article/f67e6a08eef542cd9b92d04bc2ae89dd
Autor:
Nina Geiger, Viktoria Diesendorf, Valeria Roll, Eva-Maria König, Helena Obernolte, Katherina Sewald, Julian Breidenbach, Thanigaimalai Pillaiyar, Michael Gütschow, Christa E. Müller, Jochen Bodem
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3972 (2023)
Recently, we have described novel pyridyl indole esters and peptidomimetics as potent inhibitors of the severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) main protease. Here, we analysed the impact of these compounds on viral replicat
Externí odkaz:
https://doaj.org/article/50b34bd95baa44908120300269e30a3a
Autor:
Maik Friedrich, Gabriele Pfeifer, Stefanie Binder, Achim Aigner, Philippe Vollmer Barbosa, Gustavo R. Makert, Jasmin Fertey, Sebastian Ulbert, Jochen Bodem, Eva-Maria König, Nina Geiger, Axel Schambach, Erik Schilling, Tilo Buschmann, Sunna Hauschildt, Ulrike Koehl, Katherina Sewald
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
In 2019, the novel highly infectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak rapidly led to a global pandemic with more than 346 million confirmed cases worldwide, resulting in 5.5 million associated deaths (January 2022
Externí odkaz:
https://doaj.org/article/5e20b36e65524f26869b0193cc22cccf