Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Katherin Patsch"'
Autor:
Erin R. Spiller, Nolan Ung, Seungil Kim, Katherin Patsch, Roy Lau, Carly Strelez, Chirag Doshi, Sarah Choung, Brandon Choi, Edwin Francisco Juarez Rosales, Heinz-Josef Lenz, Naim Matasci, Shannon M. Mumenthaler
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Three-quarters of compounds that enter clinical trials fail to make it to market due to safety or efficacy concerns. This statistic strongly suggests a need for better screening methods that result in improved translatability of compounds during the
Externí odkaz:
https://doaj.org/article/bec0df2719ab48b1a20e97ae10530083
Autor:
Katherin Patsch, Naim Matasci, Anjana Soundararajan, Patricia Diaz, David B. Agus, Daniel Ruderman, Mitchell E. Gross
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-7 (2019)
Abstract Objective Cell-free DNA (cfDNA) is an attractive cancer biomarker, as it is thought to reflect a component of the underlying genetic makeup of the tumor and is readily accessible in serial fashion. Because chemotherapy regimens are expected
Externí odkaz:
https://doaj.org/article/b6b28c1fefbe4213905ffdd9b4b4e7d9
Autor:
Patricia M Diaz, Katherin Patsch, Daniel Ruderman, Mitchell E. Gross, Naim Matasci, David B. Agus, Anjana Soundararajan
Publikováno v:
BMC Research Notes, Vol 12, Iss 1, Pp 1-7 (2019)
BMC Research Notes
BMC Research Notes
Objective Cell-free DNA (cfDNA) is an attractive cancer biomarker, as it is thought to reflect a component of the underlying genetic makeup of the tumor and is readily accessible in serial fashion. Because chemotherapy regimens are expected to act ra
Autor:
Grzegorz Zapotoczny, Katherin Patsch, Ren X. Sun, Mayada Aljehani, Jerry S.H. Lee, Charles E. McKenna, Chen Yu, David B. Agus, Yuanye Sun, Nolan Ung, Bethany Haliday, Harish Sura, Boris A. Kashemirov, Chao Liu, Daniel Ruderman
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Small molecules that target the androgen receptor (AR) are the mainstay of therapy for lethal castration-resistant prostate cancer (CRPC), yet existing drugs lose their efficacy during continued treatment. This evolution of resistance is due to heter
Autor:
Maya Aljehani, Daniel Ruderman, Charles E. McKenna, David B. Agus, Yuanye Sun, Ren X. Sun, Ah Young Joo, Boris A. Kashemirov, Pavan P. Shah, Harish Sura, Nolan Ung, Katherin Patsch, Grzegorz Zapotoczny, Sujatha Chilakala, Jonathan E. Katz, Chao Liu
Publikováno v:
Cancer Research. 80:5339-5339
Small molecules that target the androgen receptor (AR) are the mainstay of therapy for lethal castration-resistant prostate cancer (CRPC), but they ultimately lead to resistance and progression to terminal disease. While individual resistance-associa
Publikováno v:
Cellular Heterogeneity ISBN: 9781493976799
Methods Mol Biol
Methods Mol Biol
Cells display broad heterogeneity across multiple phenotypic features, including motility, morphology, and cell signaling. Live-cell imaging techniques are beginning to capture the importance and interdependence of these phenomena. However, existing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7e3b7d30c31da3266e9c481c260affc
https://doi.org/10.1007/978-1-4939-7680-5_3
https://doi.org/10.1007/978-1-4939-7680-5_3
Autor:
David B. Agus, Chi-Li Chiu, Katherin Patsch, Mark Engeln, Shannon M. Mumenthaler, Parag Mallick, Daniel Ruderman
Publikováno v:
Scientific Reports
Live cell imaging has improved our ability to measure phenotypic heterogeneity. However, bottlenecks in imaging and image processing often make it difficult to differentiate interesting biological behavior from technical artifact. Thus there is a nee
Autor:
David B. Agus, Scott E. Fraser, Francesco Cutrale, Chi-Li Chiu, Daniel Ruderman, Katherin Patsch, Anjana Soundararajan
Publikováno v:
Scientific Reports
The androgen receptor (AR) pathway plays a central role in prostate cancer (PCa) growth and progression and is a validated therapeutic target. In response to ligand binding AR translocates to the nucleus, though the molecular mechanism is not well un
Autor:
Christina Van Loy, Jonathan P. Katz, Antonio Sanchez, Anjana Soundararajan, Mitchell E. Gross, Zhao Xu, Erika Feierstein, Daniel Ruderman, Katherin Patsch, Naim Matasci, David B. Agus, John Nicoll
Publikováno v:
Cancer Research. 77:3934-3934
Survival rates for patients with muscle-invasive bladder cancer have not improved in the past 20 years, and new therapies are imperative. Intratumor heterogeneity can complicate molecular profiling attempts to optimize therapy for cancers harboring s
Autor:
Daniel Ruderman, Katherin Patsch, Patricia M Diaz, Naim Matasci, Mitchell E. Gross, Anjana Soundararajan
Publikováno v:
Cancer Research. 77:A20-A20
Background: There is great interest in utilizing blood-based circulating biomarkers to gain molecular insight into cancer. Most of the published data examines circulating free DNA (cfDNA) obtained at a single time-point. Here, we developed and utiliz