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pro vyhledávání: '"Katherin A. Gabriel"'
Autor:
David I. Duron, Parthasaradhireddy Tanguturi, Christopher S. Campbell, Kerry Chou, Paul Bejarano, Katherin A. Gabriel, Jessica L. Bowden, Sanket Mishra, Christopher Brackett, Deborah Barlow, Karen L. Houseknecht, Brian S. J. Blagg, John M. Streicher
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-18 (2024)
Abstract Opioids are the gold standard for the treatment of chronic pain but are limited by adverse side effects. In our earlier work, we showed that Heat shock protein 90 (Hsp90) has a crucial role in regulating opioid signaling in spinal cord; Hsp9
Externí odkaz:
https://doaj.org/article/224dd647f0154ca4bb4c8f2811b73164
Autor:
Katherin A. Gabriel, John M. Streicher
Publikováno v:
Science Signaling. 16
Opioids and other agonists of the μ-opioid receptor are effective at managing acute pain, but their chronic use can lead to tolerance that limits their efficacy. We previously reported that inhibiting the chaperone protein HSP90 in the spinal cords