Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Katharine T. Briggs"'
Publikováno v:
Human Vaccines & Immunotherapeutics, Vol 19, Iss 2 (2023)
Vaccine sedimentation and resuspension are properties that vaccine makers use to characterize a suspension product during research and development as well as throughout the shelf life of the vaccine. Three vaccines with three different aluminum adjuv
Externí odkaz:
https://doaj.org/article/02b754e49183408b805a5c50bb72a699
Autor:
Marc B. Taraban, Katharine T. Briggs, Yihua Bruce Yu, Michael T. Jones, Lindsey Rosner, Akhilesh Bhambhani, Donna M. Williams, Christopher Farrell, Mikhail Reibarkh, Yongchao Su
Publikováno v:
Pharmaceutical Research.
This study applies an emerging analytical technology, wNMR (water proton nuclear magnetic resonance), to assess the stability of aluminum adjuvants and antigen-adjuvant complexes against physical stresses, including gravitation, flow and freeze/thaw.
Publikováno v:
Vaccine. 38:4853-4860
Aluminum-adjuvanted vaccines are freeze-sensitive products that require attentive cold chain adherence. Freeze/thaw events can be tested using "The World Health Organization Shake Test", a qualitative test whereby a vial from the batch suspected to h
Publikováno v:
Annals of Allergy, Asthma & Immunology. 128:477-478
Publikováno v:
Vaccine
A recent commentary in this journal proposes looking beyond polyethylene glycols (PEG) when investigating anaphylactic reactions to mRNA COVID-19 vaccines [1]. It suggests examining other ingredients in those vaccines as potential causes of anaphylax
Publikováno v:
J Diabetes Sci Technol
Background: There is a clear need to transition from batch-level to vial/syringe/pen-level quality control of biologic drugs, such as insulin. This could be achieved only by noninvasive and quantitative inspection technologies that maintain the integ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c89d14eb0c9fa30bdfaf8fb28d7575d
https://europepmc.org/articles/PMC9631543/
https://europepmc.org/articles/PMC9631543/
Autor:
Daniel Deredge, Zhong-Xing Jiang, Yihua Bruce Yu, Margaret E. Smith, Katharine T. Briggs, Yu Li, Marc B. Taraban, Patrick L. Wintrode
Publikováno v:
Magnetic Resonance in Chemistry. 57:861-872
The conformational transition of a fluorinated amphiphilic dendrimer is monitored by the 1 H signal from water, alongside the 19 F signal from the dendrimer. High-field NMR data (chemical shift δ, self-diffusion coefficient D, longitudinal relaxatio
Autor:
Katharine T. Briggs, Daniel Deredge, Yu Li, Yihua Bruce Yu, Yue Feng, Margaret E. Smith, Marc B. Taraban, Zhong-Xing Jiang, Patrick L. Wintrode
Publikováno v:
RSC Advances. 9:1956-1966
Unlike many known amphiphiles, the fluorinated amphiphilic dendrimer studied in this work demonstrated a concentration-dependent conformational transition rather than micellization or assembly. Hydrophobic and hydrophilic interactions with water were
Publikováno v:
Pharmaceutical Research
Biologics are complex pharmaceuticals that include formulated proteins, plasma products, vaccines, cell and gene therapy products, and biological tissues. These products are fragile and typically require cold chain for their delivery and storage. Del
Publikováno v:
Current Protocols in Protein Science. 99
The water-proton signal, overwhelmingly considered a nuisance in nuclear magnetic resonance spectroscopy, is advantageously used as a tool to assess protein concentration and to detect protein aggregates in aqueous solutions. The protocols in this ar