Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Katharine S. Tuttle"'
Autor:
Dhiraj Mannar, James W. Saville, Chad Poloni, Xing Zhu, Alison Bezeruk, Keith Tidey, Sana Ahmed, Katharine S. Tuttle, Faezeh Vahdatihassani, Spencer Cholak, Laura Cook, Theodore S. Steiner, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract The XBB.1.5 variant of SARS-CoV-2 has rapidly achieved global dominance and exhibits a high growth advantage over previous variants. Preliminary reports suggest that the success of XBB.1.5 stems from mutations within its spike glycoprotein,
Externí odkaz:
https://doaj.org/article/ae5378a14a484288800e9c8db99f2846
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
SARS-CoV-2 variants have accumulated multiple defining mutations within their spike glycoproteins. Here, the authors report a structural basis for broad neutralization of several variants by a heavy chain antibody fragment and provide a mutational an
Externí odkaz:
https://doaj.org/article/8507bc9f2a6c4b9e85210fb73299d3d4
Autor:
James W. Saville, Dhiraj Mannar, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Jean-Philippe Demers, Steven Zhou, Katharine S. Tuttle, Inna Sekirov, Andrew Kim, Wei Li, Dimiter S. Dimitrov, Sriram Subramaniam
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Saville, Mannar et al. provide a structural basis for enhanced antibody evasion and ACE2 binding by the Delta SARS-CoV-2 spike protein. They further identify a head-to-head dimer-of-trimers cryoEM reconstruction unique to the Kappa variant spike.
Externí odkaz:
https://doaj.org/article/feef3d51eb6145eeb9cb3f29799a3060
Autor:
Gloria M. Sheynkman, Katharine S. Tuttle, Florent Laval, Elizabeth Tseng, Jason G. Underwood, Liang Yu, Da Dong, Melissa L. Smith, Robert Sebra, Luc Willems, Tong Hao, Michael A. Calderwood, David E. Hill, Marc Vidal
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Most human protein-coding genes are expressed as multiple isoforms. Here the authors present ORF Capture-seq that uses cloned ORFs as probes to capture and sequence full length transcript sequences. This enables highly sensitive characterization of e
Externí odkaz:
https://doaj.org/article/ffc16f1b155945bdb289f197b519b95e
Autor:
Spencer Cholak, James W. Saville, Xing Zhu, Alison M. Berezuk, Katharine S. Tuttle, Omid Haji-Ghassemi, Francisco J. Alvarado, Filip Van Petegem, Sriram Subramaniam
Publikováno v:
Structure.
Autor:
Dhiraj Mannar, James W. Saville, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Katharine S. Tuttle, Ana Citlali Marquez, Inna Sekirov, Sriram Subramaniam
Publikováno v:
Science. 375:760-764
The newly reported Omicron variant is poised to replace Delta as the most prevalent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant across the world. Cryo–electron microscopy (cryo-EM) structural analysis of the Omicron variant
Autor:
James W. Saville, Dhiraj Mannar, Xing Zhu, Alison M. Berezuk, Spencer Cholak, Katharine S. Tuttle, Faezeh Vahdatihassani, Sriram Subramaniam
Publikováno v:
Cell Reports. 42:111964
Autor:
Dhiraj Mannar, James W. Saville, Xing Zhu, Shanti S. Srivastava, Alison M. Berezuk, Katharine S. Tuttle, Citlali Marquez, Inna Sekirov, Sriram Subramaniam
The newly reported Omicron variant is poised to replace Delta as the most rapidly spread SARS-CoV-2 variant across the world. Cryo-EM structural analysis of the Omicron variant spike protein in complex with human ACE2 reveals new salt bridges and hyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2cdf3eafcbbbed6176389b78c0058f4f
https://doi.org/10.1101/2021.12.19.473380
https://doi.org/10.1101/2021.12.19.473380
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we report the discovery of a novel antibody fragment (VH ab6) that neutralizes all major variants,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::599b36466a717133151dfb669d3c98dc
https://doi.org/10.1101/2021.12.17.473178
https://doi.org/10.1101/2021.12.17.473178
Autor:
Dhiraj Mannar, James W. Saville, Zehua Sun, Xing Zhu, Michelle M. Marti, Shanti S. Srivastava, Alison M. Berezuk, Steven Zhou, Katharine S. Tuttle, Michele D. Sobolewski, Andrew Kim, Benjamin R. Treat, Priscila Mayrelle Da Silva Castanha, Jana L. Jacobs, Simon M. Barratt-Boyes, John W. Mellors, Dimiter S. Dimitrov, Wei Li, Sriram Subramaniam
Publikováno v:
Nature communications. 13(1)
Mutations in the spike glycoproteins of SARS-CoV-2 variants of concern have independently been shown to enhance aspects of spike protein fitness. Here, we describe an antibody fragment (VH ab6) that neutralizes all major variants including the recent