Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Katharine S. Knappenberger"'
Autor:
Schmiesing Richard, Chapdelaine Marc, Katharine S. Knappenberger, Hui-Fang Chang, Xiaodong F. Liu, Steven Wesolowski, Jeffrey L. Arriza
Publikováno v:
Bioorganic & Medicinal Chemistry. 18:8374-8382
Positive modulators at benzodiazepine sites of α2- and α3-containing GABA(A) receptors are believed to be anxiolytic. Negative allosteric modulators of α5-containing GABA(A) receptors enhance cognition. By oocyte two-electrode voltage clamp and su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20606d1bd594a2abb046b2168086d99a
https://doi.org/10.1016/j.bmc.2010.09.058
https://doi.org/10.1016/j.bmc.2010.09.058
Autor:
Gaochao Tian, Barry D. Greenberg, Cynthia D. Sobotka-Briner, Smita V. Ghanekar, Clay W Scott, Xiaomei Ye, Katharine S. Knappenberger
Publikováno v:
Biochemistry. 43:6208-6218
Maturation of gamma-secretase requires an endoproteolytic cleavage in presenilin-1 (PS1) within a peptide loop encoded by exon 9 of the corresponding gene. Deletion of the loop has been demonstrated to cause familial Alzheimer's disease. A synthetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b3fa07fe56c84be2f1de68a2fe273ce
https://doi.org/10.1021/bi036072v
https://doi.org/10.1021/bi036072v
Autor:
Charles S. Elmore, James J. Doherty, Katharine S. Knappenberger, Vijay Chhajlani, Nathan Spear, Peter N. Dorff, Hongyan Liu, Dan Widzowski, Linda A. Sygowski, John R. Zysk
Publikováno v:
Synapse (New York, N.Y.). 65(1)
We previously reported the absence of high-affinity binding of the group II metabotropic glutamate receptor agonists LY 354,740 and LY 379,268 to the D2L dopamine receptor. A rebuttal to our findings has since been reported (see Introduction section)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0a1224cd12ee9c453232b2593207ed9
https://pubmed.ncbi.nlm.nih.gov/20506301
https://pubmed.ncbi.nlm.nih.gov/20506301
Autor:
Deidre E. Wilkins, Lois Ann Lazor, Clay W Scott, Linda A. Sygowski, Matthew F. Peters, Jianwei Liu, Katharine S. Knappenberger
Publikováno v:
Journal of biomolecular screening. 12(3)
Cellular dielectric spectroscopy (CDS) is an emerging technology capable of detecting a range of whole-cell responses in a label-free manner. A new CDS-based instrument, CellKey, has been developed that is optimized for G-protein coupled receptor (GP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84700e3b4caa4cb9713096f672afeb79
https://pubmed.ncbi.nlm.nih.gov/17307886
https://pubmed.ncbi.nlm.nih.gov/17307886
Autor:
Katharine S. Knappenberger, Clay W Scott, Ewa Nilsson, Jianwei Liu, Christine Dartsch, Helena Käck, Gunilla Andersson
Publikováno v:
Molecular endocrinology (Baltimore, Md.). 17(3)
Estrogen receptor (ER)-mediated gene transcription occurs via the formation of a multimeric complex including ligand-activated receptors and nuclear coactivators. We have developed a homogeneous in vitro functional assay to help study the ligand-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a83c8677d773172500d1c6a8d91ae7
https://pubmed.ncbi.nlm.nih.gov/12554768
https://pubmed.ncbi.nlm.nih.gov/12554768
Autor:
Gary Steelman, Chapdelaine Marc, Katharine S. Knappenberger, Rebecca Urbanek, Linda A. Sygowski, Chris Allan Veale, Suzanne J. Suchard
Publikováno v:
Journal of medicinal chemistry. 44(11)
The cytosolic portion of CD45, a major transmembrane glycoprotein found on nucleated hematopoietic cells, contains protein tyrosine phosphatase activity and is critical for T-cell receptor-mediated T-cell activation. CD45 inhibitors could have utilit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a07aa51ead48427766f08fef7f9132a
https://pubmed.ncbi.nlm.nih.gov/11356112
https://pubmed.ncbi.nlm.nih.gov/11356112