Zobrazeno 1 - 10
of 88
pro vyhledávání: '"Katharine R. Trenholme"'
Autor:
Rebecca Webster, Silvana Sekuloski, Anand Odedra, Stephen Woolley, Helen Jennings, Fiona Amante, Katharine R. Trenholme, Julie Healer, Alan F. Cowman, Emily M. Eriksson, Priyanka Sathe, Jocelyn Penington, Adam J. Blanch, Matthew W. A. Dixon, Leann Tilley, Michael F. Duffy, Alister Craig, Janet Storm, Jo-Anne Chan, Krystal Evans, Anthony T. Papenfuss, Louis Schofield, Paul Griffin, Bridget E. Barber, Dean Andrew, Michelle J. Boyle, Fabian de Labastida Rivera, Christian Engwerda, James S. McCarthy
Publikováno v:
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Abstract Background There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuated blood-stage vaccine and test its safety, infectivity, and immunogenicity in healthy volunteers. Our approach w
Externí odkaz:
https://doaj.org/article/74cfc9b904474091b17850c1e5910004
Autor:
Corine G. Demanga, Jenny W. L. Eng, Donald L. Gardiner, Alison Roth, Alice Butterworth, John H. Adams, Katharine R. Trenholme, John P. Dalton
Publikováno v:
Parasites & Vectors, Vol 10, Iss 1, Pp 1-12 (2017)
Abstract Background Blocking malaria gametocyte development in RBCs or their fertilization in the mosquito gut can prevent infection of the mosquito vector and passage of disease to the human host. A ‘transmission blocking’ strategy is a componen
Externí odkaz:
https://doaj.org/article/8c4f7122c0874c8193f084c960d32ee6
Autor:
Karine Thivierge, Rency T. Mathew, Desire M. M. Nsangou, Fabio Da Silva, Sophie Cotton, Tina S. Skinner-Adams, Katharine R. Trenholme, Christopher L. Brown, Colin M. Stack, Donald L. Gardiner, John P. Dalton
Publikováno v:
ARKIVOC, Vol 2012, Iss 4, Pp 330-346 (2012)
Externí odkaz:
https://doaj.org/article/3d531d6849984330a80c2835c0d9cffb
Publikováno v:
Journal of Medicinal Chemistry. 63:13330-13354
Giardia parasites are ubiquitous protozoans of global importance that impact a wide range of animals including humans. They are the most common enteric pathogen of cats and dogs in developed countries and infect ∼1 billion people worldwide. While G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c48cd83ffce0a34edc60d10ea42a3dac
https://doi.org/10.1021/acs.jmedchem.0c00910
https://doi.org/10.1021/acs.jmedchem.0c00910
Autor:
Leann Tilley, Helen Jennings, Paul M. Griffin, Stephen Woolley, Anthony T. Papenfuss, Michelle J. Boyle, Fiona H. Amante, Jocelyn Sietsma Penington, Silvana Sekuloski, James S. McCarthy, Fabian de Labastida Rivera, Katharine R. Trenholme, Bridget E. Barber, Jo-Anne Chan, Emily M. Eriksson, Christian R. Engwerda, Anand Odedra, Michael F. Duffy, Dean Andrew, Alister Craig, Krystal J. Evans, Priyanka Sathe, Matthew W. A. Dixon, Julie Healer, Janet Storm, Rebecca Webster, Adam J. Blanch, Alan F. Cowman, Louis Schofield
Publikováno v:
BMC Medicine
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
BMC Medicine, Vol 19, Iss 1, Pp 1-13 (2021)
Background There is a clear need for novel approaches to malaria vaccine development. We aimed to develop a genetically attenuated blood-stage vaccine and test its safety, infectivity, and immunogenicity in healthy volunteers. Our approach was to tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::905f9c5e2aad5e0e211480124a63b8f7
https://pubmed.ncbi.nlm.nih.gov/34802442
https://pubmed.ncbi.nlm.nih.gov/34802442
Autor:
Katharine R. Trenholme, Donald L. Gardiner, Patrick R. Griffin, Peter Chase, Louis Scampavia, Timothy P. Spicer, Peter Hodder, Sudeshna Roy, Frank J. Schoenen
Publikováno v:
SLAS Discovery. 24:38-46
Malaria remains a major cause of morbidity and mortality worldwide with ~3.3 billion people at risk of contracting malaria and an estimated 450,000 deaths each year. While tools to reduce the infection prevalence to low levels are currently under dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0d8d36828ca385237e97203ebc2210
https://doi.org/10.1177/2472555218796410
https://doi.org/10.1177/2472555218796410
Autor:
Louise Marquart, Joerg J. Moehrle, James S. McCarthy, Stephan Chalon, Stacey Llewellyn, Fiona H. Amante, Stephen Woolley, Bridget E. Barber, Maria Rebelo, Helen Jennings, Melissa Fernandez, Rebecca Webster, Katharine R. Trenholme
Publikováno v:
Malaria Journal, Vol 20, Iss 1, Pp 1-9 (2021)
Malaria Journal
Malaria Journal
Background New anti-malarial therapeutics are required to counter the threat of increasing drug resistance. Malaria volunteer infection studies (VIS), particularly the induced blood stage malaria (IBSM) model, play a key role in accelerating anti-mal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d2002d6ed2d07b288d82f9043b77212
https://archive.lstmed.ac.uk/16980/2/12936_2021_Article_3627.pdf
https://archive.lstmed.ac.uk/16980/2/12936_2021_Article_3627.pdf
Publikováno v:
Journal of medicinal chemistry. 63(22)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::6bda82c0a890071767c64452ddc2d81d
https://pubmed.ncbi.nlm.nih.gov/32869995
https://pubmed.ncbi.nlm.nih.gov/32869995
Autor:
Xue Q. Liu, Yuedong Yang, Lana Sundac, James S. McCarthy, Christine Langer, Yaoqi Zhou, Hazel Hackett, Silvana Sekuloski, James Fink, John Gerrard, Eric Hanssen, Stephen L. Hoffman, Katharine R. Trenholme, Jolien Pingnet, Ingrid B. Rodriguez, Michael F. Good, James G. Beeson, Paul M. Griffin, Claire Y. T. Wang, Jo-Anne Chan, Danielle I. Stanisic
Publikováno v:
Infection and Immunity. 84:2689-2696
Plasmodium falciparum is the most virulent human malaria parasite because of its ability to cytoadhere in the microvasculature. Nonhuman primate studies demonstrated relationships among knob expression, cytoadherence, and infectivity. This has not be
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f87bd6463a4e481ebb054fce2dfe5182
https://doi.org/10.1128/iai.00414-16
https://doi.org/10.1128/iai.00414-16
Autor:
Suzanne L. Elliott, Rebecca Rockett, Santiago Ferrer, Mark Baker, Timothy N. C. Wells, Theo P. Sloots, Louise Marquart, James S. McCarthy, Rob Hooft van Huijsduijnen, María Belén Jiménez-Díaz, Katharine R. Trenholme, Jörg J. Möhrle, Didier Leroy, María-Santos Martínez, Paul M. Griffin, Stephan Duparc, Peter O'Rourke, Silvana Sekuloski, Iñigo Angulo-Barturen
Publikováno v:
Antimicrobial Agents and Chemotherapy
Effective progression of candidate antimalarials is dependent on optimal dosing in clinical studies, which is determined by a sound understanding of pharmacokinetics and pharmacodynamics (PK/PD). Recently, two important translational models for antim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0cad1871eb18397dba231a1b1068231
http://europepmc.org/articles/PMC4879391
http://europepmc.org/articles/PMC4879391