Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Katharine R Smith"'
Autor:
E Mae Guthman, Joshua D Garcia, Ming Ma, Philip Chu, Serapio M Baca, Katharine R Smith, Diego Restrepo, Molly M Huntsman
Publikováno v:
eLife, Vol 9 (2020)
The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs)
Externí odkaz:
https://doaj.org/article/1935d86d414344138ff9d6dc3c140a8b
Autor:
Deepak P Srivastava, Kevin M Woolfrey, Kelly A Jones, Charles T Anderson, Katharine R Smith, Theron A Russell, Hyerin Lee, Marina V Yasvoina, David L Wokosin, P Hande Ozdinler, Gordon M G Shepherd, Peter Penzes
Publikováno v:
PLoS Biology, Vol 10, Iss 6, p e1001350 (2012)
The architecture of dendritic arbors determines circuit connectivity, receptive fields, and computational properties of neurons, and dendritic structure is impaired in several psychiatric disorders. While apical and basal dendritic compartments of py
Externí odkaz:
https://doaj.org/article/82bebeeb8c44423d9a906dbfb32001e3
Autor:
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113331- (2023)
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elemen
Externí odkaz:
https://doaj.org/article/3444965cf8894b45b28692c79eca5faf
Autor:
Joshua D. Garcia, Sarah E. Wolfe, Amber R. Stewart, Erika Tiemeier, Sara E. Gookin, Mayra Bueno Guerrero, Nidia Quillinan, Katharine R. Smith
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108061- (2023)
Summary: Synaptic inhibition is critical for controlling neuronal excitability and function. During global cerebral ischemia (GCI), inhibitory synapses are rapidly eliminated, causing hyper-excitability which contributes to cell-death and the pathoph
Externí odkaz:
https://doaj.org/article/edb341abaf2f4e43b5873403d0258911
Autor:
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses. Intriguingly, postsynapt
Externí odkaz:
https://doaj.org/article/0a611978cc574cd884372c1cb950f914
Autor:
Nicolas H. Piguel, Shaun S. Sanders, Francesca I. De Simone, Maria D. Martin-de-Saavedra, Emmarose McCoig, Leonardo E. Dionisio, Katharine R. Smith, Gareth M. Thomas, Peter Penzes
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionAnkG, encoded by the ANK3 gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node of Ranvier, whereas the 190 kDa isoform (AnkG-190) has an
Externí odkaz:
https://doaj.org/article/52a343df27d8423883a4ff7c95f0ced1
Autor:
Nicolas H. Piguel, Sehyoun Yoon, Ruoqi Gao, Katherine E. Horan, Jacob C. Garza, Tracey L. Petryshen, Katharine R. Smith, Peter Penzes
Publikováno v:
Neuropsychopharmacology. 48:1000-1010
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::37f08b52b7fe2a23d712a99240269f07
https://doi.org/10.1038/s41386-022-01502-2
https://doi.org/10.1038/s41386-022-01502-2
Autor:
Brian G. Hiester, Ashley M. Bourke, Brooke L. Sinnen, Sarah G. Cook, Emily S. Gibson, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2134-2146 (2017)
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity
Externí odkaz:
https://doaj.org/article/c6d4bff6bfc64e148fb2bd02f5186df3
Autor:
Kevin C. Crosby, Sara E. Gookin, Joshua D. Garcia, Katlin M. Hahm, Mark L. Dell’Acqua, Katharine R. Smith
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3284-3297.e3 (2019)
Summary: Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby controlling neuronal excitability, firing, and plasticity. Although essential for neuronal function, the central question of how these synapses are organiz
Externí odkaz:
https://doaj.org/article/177e5de8518b4b4f9459c49e82a08221
Autor:
Katharine R. Smith, Elizabeth C. Davenport, Jing Wei, Xiangning Li, Manavendra Pathania, Victoria Vaccaro, Zhen Yan, Josef T. Kittler
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 298-310 (2014)
Summary: Effective inhibitory synaptic transmission requires efficient stabilization of GABAA receptors (GABAARs) at synapses, which is essential for maintaining the correct excitatory-inhibitory balance in the brain. However, the signaling mechanism
Externí odkaz:
https://doaj.org/article/8862d6e1e98d4b6a8f43632ac9587754