Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Katharine R, Smith"'
Autor:
Samantha S. Olah, Dean J. Kareemo, William C. Buchta, Brooke L. Sinnen, Carley N. Miller, Hannah S. Actor-Engel, Sara E. Gookin, Christina S. Winborn, Mason S. Kleinjan, Kevin C. Crosby, Jason Aoto, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113331- (2023)
Summary: Neurotransmitter receptors partition into nanometer-scale subdomains within the postsynaptic membrane that are precisely aligned with presynaptic neurotransmitter release sites. While spatial coordination between pre- and postsynaptic elemen
Externí odkaz:
https://doaj.org/article/3444965cf8894b45b28692c79eca5faf
Autor:
Joshua D. Garcia, Sarah E. Wolfe, Amber R. Stewart, Erika Tiemeier, Sara E. Gookin, Mayra Bueno Guerrero, Nidia Quillinan, Katharine R. Smith
Publikováno v:
iScience, Vol 26, Iss 10, Pp 108061- (2023)
Summary: Synaptic inhibition is critical for controlling neuronal excitability and function. During global cerebral ischemia (GCI), inhibitory synapses are rapidly eliminated, causing hyper-excitability which contributes to cell-death and the pathoph
Externí odkaz:
https://doaj.org/article/edb341abaf2f4e43b5873403d0258911
Autor:
Harrison J. Ramsay, Sara E. Gookin, Austin M. Ramsey, Dean J. Kareemo, Kevin C. Crosby, Dominik G. Stich, Samantha S. Olah, Hannah S. Actor-Engel, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
Postsynaptic neurotransmitter receptors and their associated scaffolding proteins assemble into discrete, nanometer-scale subsynaptic domains (SSDs) within the postsynaptic membrane at both excitatory and inhibitory synapses. Intriguingly, postsynapt
Externí odkaz:
https://doaj.org/article/0a611978cc574cd884372c1cb950f914
Autor:
Nicolas H. Piguel, Shaun S. Sanders, Francesca I. De Simone, Maria D. Martin-de-Saavedra, Emmarose McCoig, Leonardo E. Dionisio, Katharine R. Smith, Gareth M. Thomas, Peter Penzes
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionAnkG, encoded by the ANK3 gene, is a multifunctional scaffold protein with complex isoform expression: the 480 and 270 kDa isoforms have roles at the axon initial segment and node of Ranvier, whereas the 190 kDa isoform (AnkG-190) has an
Externí odkaz:
https://doaj.org/article/52a343df27d8423883a4ff7c95f0ced1
Autor:
Sara E. Gookin, Matthew R. Taylor, Samantha L. Schwartz, Matthew J. Kennedy, Mark L. Dell’Acqua, Kevin C. Crosby, Katharine R. Smith
Publikováno v:
Frontiers in Synaptic Neuroscience, Vol 14 (2022)
The nanoscale architecture of synapses has been investigated using multiple super-resolution methods, revealing a common modular structure for scaffolds, neurotransmitter receptors, and presynaptic proteins. This fundamental organization of proteins
Externí odkaz:
https://doaj.org/article/ce3db4c3150a42509ceaf51515256aad
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Neurons are highly complex polarized cells, displaying an extraordinary degree of spatial compartmentalization. At presynaptic and postsynaptic sites, far from the cell body, local protein synthesis is utilized to continually modify the synaptic prot
Externí odkaz:
https://doaj.org/article/2fab1404294045748eb4162d9b564655
Autor:
E Mae Guthman, Joshua D Garcia, Ming Ma, Philip Chu, Serapio M Baca, Katharine R Smith, Diego Restrepo, Molly M Huntsman
Publikováno v:
eLife, Vol 9 (2020)
The basolateral amygdala (BLA) plays a vital role in associating sensory stimuli with salient valence information. Excitatory principal neurons (PNs) undergo plastic changes to encode this association; however, local BLA inhibitory interneurons (INs)
Externí odkaz:
https://doaj.org/article/1935d86d414344138ff9d6dc3c140a8b
Autor:
Nicolas H. Piguel, Sehyoun Yoon, Ruoqi Gao, Katherine E. Horan, Jacob C. Garza, Tracey L. Petryshen, Katharine R. Smith, Peter Penzes
Publikováno v:
Neuropsychopharmacology. 48:1000-1010
Autor:
Brian G. Hiester, Ashley M. Bourke, Brooke L. Sinnen, Sarah G. Cook, Emily S. Gibson, Katharine R. Smith, Matthew J. Kennedy
Publikováno v:
Cell Reports, Vol 21, Iss 8, Pp 2134-2146 (2017)
The repertoire and abundance of proteins displayed on the surface of neuronal dendrites are tuned by regulated fusion of recycling endosomes (REs) with the dendritic plasma membrane. While this process is critical for neuronal function and plasticity
Externí odkaz:
https://doaj.org/article/c6d4bff6bfc64e148fb2bd02f5186df3
Autor:
Kevin C. Crosby, Sara E. Gookin, Joshua D. Garcia, Katlin M. Hahm, Mark L. Dell’Acqua, Katharine R. Smith
Publikováno v:
Cell Reports, Vol 26, Iss 12, Pp 3284-3297.e3 (2019)
Summary: Inhibitory synapses mediate the majority of synaptic inhibition in the brain, thereby controlling neuronal excitability, firing, and plasticity. Although essential for neuronal function, the central question of how these synapses are organiz
Externí odkaz:
https://doaj.org/article/177e5de8518b4b4f9459c49e82a08221