Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Katharine O. Hartley"'
Publikováno v:
Developmental Biology. 238(1):168-184
In vertebrates, BMP signaling before gastrulation suppresses neural development. Later in development, BMP signaling specifies a dorsal and ventral fate in the forebrain and dorsal fate in the spinal cord. It is therefore possible that a change in th
Autor:
Nullin Divecha, Stephen P. Jackson, Katharine O. Hartley, Arie Admon, Hong Zhang, Margery A. Connelly, Carl W. Anderson, Susan P. Lees-Miller, Graeme C. M. Smith, David A. Gell
Publikováno v:
Cell. 82:849-856
DNA-dependent protein kinase (DNA-PK), which is involved in DNA double-stranded break repair and V(D)J recombination, comprises a DNA-targeting component called Ku and an ∼460 kDa catalytic subunit, DNA-PIK CS Here, we describe the cloning of the D
Autor:
Katharine O. Hartley, David C. Ward, Carl W. Anderson, Joan C. Menninger, John D. Sipley, Stephen P. Jackson
Publikováno v:
Proceedings of the National Academy of Sciences. 92:7515-7519
The DNA-activated serine/threonine protein kinase (DNA-PK) is composed of a large (approximately 460 kDa) catalytic polypeptide (DNA-PKcs) and Ku, a heterodimeric DNA-binding component (p70/p80) that targets DNA-PKcs to DNA. A 41-kbp segment of the D
The transgenic technique in Xenopus allows one to misexpress genes in a temporally and spatially controlled manner. However, this system suffers from two experimental limitations. First, the restriction enzyme-mediated integration procedure relies on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b4471a79a864a9a141734cd3a86000c
https://europepmc.org/articles/PMC122198/
https://europepmc.org/articles/PMC122198/
Publikováno v:
Genesis
Genesis, Wiley-Blackwell, 2001, 30 (3), pp.110-3
Genesis, Wiley-Blackwell, 2001, 30 (3), pp.110-3
Summary: Morpholino (MO) based inhibition of translational initiation represents an attractive methodology to eliminate gene function during Xenopus development (Heasman et al., 2000). However, the degree to which a given target protein can be elimin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57475d3b7d5ebd52b46d14eb1784c6d5
https://hal.science/hal-00741914
https://hal.science/hal-00741914
Publikováno v:
Europe PubMed Central
Publikováno v:
Current Biology. 9:1195-S1
The frog transgenesis technique ultimately promises to make mutagenesis possible through random insertion of plasmid DNA into the genome. This study was undertaken to evaluate whether a gene trap approach combined with transgenesis would be appropria