Výsledky vyhledávání - "Katharine M, Dibb"

Akademický článek

Publikováno v: eLife, Vol 12 (2023)

Ring-like structures made up of caveolae appear to drive the development of membrane invaginations called T-tubules which are important for muscle contraction.

Externí odkaz: https://doaj.org/article/5b2135525caf4ba08f27862dd427720d

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Akademický článek

Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation

Autor: Channabasavaiah B. Gurumurthy, Aidan R. O’Brien, Rolen M. Quadros, John Adams, Pilar Alcaide, Shinya Ayabe, Johnathan Ballard, Surinder K. Batra, Marie-Claude Beauchamp, Kathleen A. Becker, Guillaume Bernas, David Brough, Francisco Carrillo-Salinas, Wesley Chan, Hanying Chen, Ruby Dawson, Victoria DeMambro, Jinke D’Hont, Katharine M. Dibb, James D. Eudy, Lin Gan, Jing Gao, Amy Gonzales, Anyonya R. Guntur, Huiping Guo, Donald W. Harms, Anne Harrington, Kathryn E. Hentges, Neil Humphreys, Shiho Imai, Hideshi Ishii, Mizuho Iwama, Eric Jonasch, Michelle Karolak, Bernard Keavney, Nay-Chi Khin, Masamitsu Konno, Yuko Kotani, Yayoi Kunihiro, Imayavaramban Lakshmanan, Catherine Larochelle, Catherine B. Lawrence, Lin Li, Volkhard Lindner, Xian-De Liu, Gloria Lopez-Castejon, Andrew Loudon, Jenna Lowe, Loydie A. Jerome-Majewska, Taiji Matsusaka, Hiromi Miura, Yoshiki Miyasaka, Benjamin Morpurgo, Katherine Motyl, Yo-ichi Nabeshima, Koji Nakade, Toshiaki Nakashiba, Kenichi Nakashima, Yuichi Obata, Sanae Ogiwara, Mariette Ouellet, Leif Oxburgh, Sandra Piltz, Ilka Pinz, Moorthy P. Ponnusamy, David Ray, Ronald J. Redder, Clifford J. Rosen, Nikki Ross, Mark T. Ruhe, Larisa Ryzhova, Ane M. Salvador, Sabrina Shameen Alam, Radislav Sedlacek, Karan Sharma, Chad Smith, Katrien Staes, Lora Starrs, Fumihiro Sugiyama, Satoru Takahashi, Tomohiro Tanaka, Andrew W. Trafford, Yoshihiro Uno, Leen Vanhoutte, Frederique Vanrockeghem, Brandon J. Willis, Christian S. Wright, Yuko Yamauchi, Xin Yi, Kazuto Yoshimi, Xuesong Zhang, Yu Zhang, Masato Ohtsuka, Satyabrata Das, Daniel J. Garry, Tino Hochepied, Paul Thomas, Jan Parker-Thornburg, Antony D. Adamson, Atsushi Yoshiki, Jean-Francois Schmouth, Andrei Golovko, William R. Thompson, K. C. Kent Lloyd, Joshua A. Wood, Mitra Cowan, Tomoji Mashimo, Seiya Mizuno, Hao Zhu, Petr Kasparek, Lucy Liaw, Joseph M. Miano, Gaetan Burgio

Publikováno v: Genome Biology, Vol 20, Iss 1, Pp 1-14 (2019)

Abstract Background CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study reported up to 16% effi

Externí odkaz: https://doaj.org/article/d080d0cd1924426bb1475dd31116c836

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Akademický článek

Optimising Large Animal Models of Sustained Atrial Fibrillation: Relevance of the Critical Mass Hypothesis

Autor: Nathan C. Denham, Charles M. Pearman, George W. P. Madders, Charlotte E. R. Smith, Andrew W. Trafford, Katharine M. Dibb

Publikováno v: Frontiers in Physiology, Vol 12 (2021)

BackgroundLarge animal models play an important role in our understanding of the pathophysiology of atrial fibrillation (AF). Our aim was to determine whether prospectively collected baseline variables could predict the development of sustained AF in

Externí odkaz: https://doaj.org/article/9b71963249ce40c8b1e5a1e1a29a2c65

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Interaction of background Ca 2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca 2+ waves in sheep heart

Autor: David C. Hutchings, George W. P. Madders, Barbara C. Niort, Elizabeth F. Bode, Caitlin A. Waddell, Lori S. Woods, Katharine M. Dibb, David A. Eisner, Andrew W. Trafford

Publikováno v: Hutchings, D, Madders, G, Niort, B, Bode, E, Waddell, C, Woods, L, Dibb, K, Eisner, D & Trafford, A 2022, ' Interaction of background Ca2+ influx, sarcoplasmic reticulum threshold and heart failure in determining propensity for Ca2+ waves in sheep heart ', JOURNAL OF PHYSIOLOGY-LONDON . https://doi.org/10.1113/JP282168

Key pointsHeart failure is a pro-arrhythmic state and arrhythmias are a major cause of death. At the cellular level, Ca2+ waves resulting in delayed after-depolarisations are a key trigger of arrhythmias. Ca2+ waves arise when the sarcoplasmic reticu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba9002a54cd6ba1eab318aba7f54cc61
https://doi.org/10.1113/jp282168

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Akademický článek

Increased Vulnerability to Atrial Fibrillation Is Associated With Increased Susceptibility to Alternans in Old Sheep

Autor: Charles M. Pearman, George W.P. Madders, Emma J. Radcliffe, Graeme J. Kirkwood, Michael Lawless, Amy Watkins, Charlotte E.R. Smith, Andrew W. Trafford, David A. Eisner, Katharine M. Dibb

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 23 (2018)

Background Atrial fibrillation (AF) is common in the elderly, but rare in the young; however, the changes that occur with age that promote AF are not fully understood. Action potential (AP) alternans may be involved in the initiation of AF. Using a t

Externí odkaz: https://doaj.org/article/f7e1341037234cee820cd751d17b30eb

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Akademický článek

Calcium in the Pathophysiology of Atrial Fibrillation and Heart Failure

Autor: Nathan C. Denham, Charles M. Pearman, Jessica L. Caldwell, George W. P. Madders, David A. Eisner, Andrew W. Trafford, Katharine M. Dibb

Publikováno v: Frontiers in Physiology, Vol 9 (2018)

Atrial fibrillation (AF) is commonly associated with heart failure. A bidirectional relationship exists between the two—AF exacerbates heart failure causing a significant increase in heart failure symptoms, admissions to hospital and cardiovascular

Externí odkaz: https://doaj.org/article/64909765f54e44ed91259196e8f432e2

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Serial block face scanning electron microscopy reveals region-dependent remodelling of transverse tubules post-myocardial infarction

Autor: Tharushi Perera, Charlene Pius, Barbara Niort, Emma J. Radcliffe, Katharine M. Dibb, Andrew W. Trafford, Christian Pinali

Publikováno v: Philosophical Transactions of the Royal Society B: Biological Sciences. 377

The highly organized transverse tubule (t-tubule) network facilitates cardiac excitation–contraction coupling and synchronous cardiac myocyte contraction. In cardiac failure secondary to myocardial infarction (MI), changes in the structure and orga

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::674b23af15cc4d17ae3e7793d5742ed4
https://doi.org/10.1098/rstb.2021.0331

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PDE5 Inhibition Suppresses Ventricular Arrhythmias by Reducing SR Ca2+ Content

Autor: David Hutchings, David A. Eisner, George W.P. Madders, Andrew W. Trafford, Katharine M. Dibb, Charles M. Pearman, Lori Woods

Publikováno v: Circulation Research
Hutchings, D, Pearman, C, Madders, G, Woods, L, Eisner, D, Dibb, K & Trafford, A 2021, ' PDE5 inhibition suppresses ventricular arrhythmias by reducing SR Ca2+ content ', Circulation research . https://doi.org/10.1161/CIRCRESAHA.121.318473

Supplemental Digital Content is available in the text.
Rationale: PDE5 (phosphodiesterase 5) inhibition reduces the occurrence of ventricular arrhythmias following myocardial ischemia. However, the mechanisms of the antiarrhythmic effects of PDE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810e2998d6815c59de9628f6750c1691
http://europepmc.org/articles/PMC8409902

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Enhanced calcium release at specialised surface sites compensates for reduced t-tubule density in neonatal sheep atrial myocytes

Autor: Charlotte E.R. Smith, Christian Pinali, David A. Eisner, Andrew W. Trafford, Katharine M. Dibb

Publikováno v: Smith, C E R, Pinali, C, Eisner, D, Trafford, A & Dibb, K 2022, ' Enhanced calcium release at specialised surface sites compensates for reduced t-tubule density in neonatal sheep atrial myocytes ', Journal of molecular and cellular cardiology . https://doi.org/10.1016/j.yjmcc.2022.08.360

Cardiac myocytes rely on transverse (t)-tubules to facilitate a rapid rise in calcium throughout the cell. However, despite their importance in triggering synchronous Ca2+ release, t-tubules are highly labile structures. They develop postnatally, inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77c8045946ab38a0faf98e1324fe3042
https://research.manchester.ac.uk/en/publications/c6f2ded7-77f9-4c7b-862b-dc389469c836

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Altered atrial cytosolic calcium handling contributes to the development of postoperative atrial fibrillation

Publikováno v: Fakuade, F E, Steckmeister, V, Seibertz, F, Gronwald, J, Kestel, S, Menzel, J, Pronto, J R D, Taha, K, Haghighi, F, Kensah, G, Pearman, C M, Wiedmann, F, Teske, A J, Schmidt, C, Dibb, K M, El-Essawi, A, Danner, B C, Baraki, H, Schwappach, B, Kutschka, I, Mason, F E & Voigt, N 2020, ' Altered Atrial Cytosolic Calcium Handling Contributes to the Development of Postoperative Atrial Fibrillation ', Cardiovascular research . https://doi.org/10.1093/cvr/cvaa162

AIMS: Atrial fibrillation is a commonly occurring arrhythmia after cardiac surgery (postoperative AF, poAF) and is associated with poorer outcomes. Considering that reduced atrial contractile function is a predictor of poAF and that Ca2+ plays an imp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e66d1a42ba9e37828433165a4199b35
https://doi.org/10.1093/cvr/cvaa162

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