Zobrazeno 1 - 10
of 23
pro vyhledávání: '"Katharine L Korunes"'
Publikováno v:
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers. We developed a gene expressio
Externí odkaz:
https://doaj.org/article/a6f90dc8485844a99504f10b8a393b32
Autor:
Katharine L Korunes, Amy Goldberg
Publikováno v:
PLoS Genetics, Vol 17, Iss 3, p e1009374 (2021)
Throughout human history, large-scale migrations have facilitated the formation of populations with ancestry from multiple previously separated populations. This process leads to subsequent shuffling of genetic ancestry through recombination, produci
Externí odkaz:
https://doaj.org/article/5a85901c3ef24b5f99177027b5cf9d0d
Publikováno v:
eLife, Vol 10 (2021)
Humans have undergone large migrations over the past hundreds to thousands of years, exposing ourselves to new environments and selective pressures. Yet, evidence of ongoing or recent selection in humans is difficult to detect. Many of these migratio
Externí odkaz:
https://doaj.org/article/6e18ea64f5da47d58d6fac5c26c80f5b
Publikováno v:
Fly, Vol 15, Iss 1, Pp 38-44 (2021)
Drosophila pseudoobscura is a classic model system for the study of evolutionary genetics and genomics. Given this long-standing interest, many genome sequences have accumulated for D. pseudoobscura and closely related species D. persimilis, D. miran
Externí odkaz:
https://doaj.org/article/6c46efb15df04c619d2d7e4fb33a6e21
Gene flow between previously differentiated populations during the founding of an admixed or hybrid population has the potential to introduce adaptive alleles into the new population. If the adaptive allele is common in one source population, but not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe64df41cc98fe56838ac89a04e367fa
https://doi.org/10.1101/2022.09.04.506532
https://doi.org/10.1101/2022.09.04.506532
Publikováno v:
Evolution. 75:1820-1834
By shaping meiotic recombination, chromosomal inversions can influence genetic exchange between hybridizing species. Despite the recognized importance of inversions in evolutionary processes such as divergence and speciation, teasing apart the effect
Autor:
Amy Goldberg, Sandra Beleza, Isabel Inês Araújo, Hua Tang, Giordano B. Soares-Souza, Katharine L Korunes, Katherine Bobrek
Publikováno v:
G3 (Bethesda, Md.). 12(10)
Genetic data can provide insights into population history, but first, we must understand the patterns that complex histories leave in genomes. Here, we consider the admixed human population of Cabo Verde to understand the patterns of genetic variatio
Publikováno v:
Fly. 15:38-44
Drosophila pseudoobscura is a classic model system for the study of evolutionary genetics and genomics. Given this long-standing interest, many genome sequences have accumulated for D. pseudoobscura and closely related species D. persimilis, D. miran
Thresholds Derived From Common Measures in Rat Studies Are Predictive of Liver Tumorigenic Chemicals
Autor:
J. Christopher Corton, Hisham A. El-Masri, Katharine L Korunes, John P. Rooney, Shihan He, Cari Martini, Jason M. Brown, Ying Liu, Katie Paul-Friedman, Jaleh Abedini
Publikováno v:
Toxicol Pathol
We hypothesized that typical tissue and clinical chemistry (ClinChem) end points measured in rat toxicity studies exhibit chemical-independent biological thresholds beyond which cancer occurs. Using the rat in vivo TG-GATES study, 75 chemicals were e
Autor:
Katharine L. Korunes, Jie Liu, Ruili Huang, Menghang Xia, Keith A. Houck, J. Christopher Corton
Publikováno v:
PLoS ONE
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
PLoS ONE, Vol 17, Iss 2, p e0261854 (2022)
The nuclear factor-kappa B (NF-κB) is a transcription factor with important roles in inflammation, immune response, and oncogenesis. Dysregulation of NF-κB signaling is associated with inflammation and certain cancers. We developed a gene expressio