Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Katharine K. Duncan"'
Publikováno v:
Frontiers in Robotics and AI, Vol 6 (2020)
In recent years, artificial intelligence (AI)/machine learning (ML; a subset of AI) have become increasingly important to the biomedical research community. These technologies, coupled to big data and cheminformatics, have tremendous potential to imp
Externí odkaz:
https://doaj.org/article/ef58734196de4f69a73aeb92f789b61f
Autor:
Thomas A. Munro, Katharine K. Duncan, Richard J. Staples, Wei Xu, Lee-Yuan Liu-Chen, Cécile Béguin, William A. Carlezon Jr., Bruce M. Cohen
Publikováno v:
Beilstein Journal of Organic Chemistry, Vol 3, Iss 1, p 1 (2007)
There have been many reports of epimerization of salvinorins at C-8 under basic conditions, but little evidence has been presented to establish the structure of these compounds. We report here the first crystal structure of an 8-epi-salvinorin or der
Externí odkaz:
https://doaj.org/article/9f810eb341a9481ab86113fa8452e2f7
Publikováno v:
Frontiers in Robotics and AI, Vol 6 (2020)
Frontiers in Robotics and AI
Frontiers in Robotics and AI
In recent years, artificial intelligence (AI)/machine learning (ML; a subset of AI) have become increasingly important to the biomedical research community. These technologies, coupled to big data and cheminformatics, have tremendous potential to imp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca1afd9bbeb238378a68905a859e2db8
https://doi.org/10.3389/frobt.2019.00143
https://doi.org/10.3389/frobt.2019.00143
Autor:
Dale L. Boger, Shouliang Yang, R. Matthew Cross, Daniel W. Carney, Aleksandar Radakovic, Daniel M. Brody, Vyom Shukla, John C. Lukesh, Katharine K. Duncan, Manuela M. Brütsch, Huijun Dong
Publikováno v:
Journal of Medicinal Chemistry. 60:7591-7604
A series of 180 vinblastine 20' amides were prepared in three steps from commercially available starting materials, systematically exploring a typically inaccessible site in the molecule enlisting a powerful functionalization strategy. Clear structur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9f59c28cf90ee2feb2751e99d442147
https://doi.org/10.1021/acs.jmedchem.7b00958
https://doi.org/10.1021/acs.jmedchem.7b00958
Publikováno v:
Organic Letters. 15:5306-5309
A powerful tandem [4 + 2]/[3 + 2] cycloaddition cascade of 1,3,4-oxadiazoles initiated by a transannular [4 + 2] cycloaddition is detailed. An impressive four rings, four carbon-carbon bonds, and six stereocenters are set on each site of the newly fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058f42f83c2f6796e80539aa885141ce
https://doi.org/10.1021/ol402549n
https://doi.org/10.1021/ol402549n
Publikováno v:
ACS Medicinal Chemistry Letters. 4:985-988
A series of disubstituted C20′-urea derivatives of vinblastine were prepared from 20′-aminovinblastine that was made accessible through a unique Fe(III)/NaBH4-mediated alkene functionalization reaction of anhydrovinblastine. Three analogues were
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9ccf0418961f923a4cf03bc2f6dfda
https://doi.org/10.1021/ml400281w
https://doi.org/10.1021/ml400281w
Autor:
Erick K. Leggans, Timothy J. Barker, Kristin D. Schleicher, Dale L. Boger, Katharine K. Duncan
Publikováno v:
Journal of Medicinal Chemistry. 56:628-639
A systematic series of previously inaccessible key C20' urea and thiourea derivatives of vinblastine were prepared from 20'-aminovinblastine that was made accessible through a unique Fe(III)/NaBH(4)-mediated alkene functionalization reaction of anhyd
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf0a9fc70aa9f0e3bf4deb5a610e6c6
https://doi.org/10.1021/jm3015684
https://doi.org/10.1021/jm3015684
Publikováno v:
Organic Letters. 14:1428-1431
An Fe(III)/NaBH(4)-mediated reaction for the functionalization of unactivated alkenes is described defining the alkene substrate scope, establishing the exclusive Markovnikov addition, exploring a range of free radical traps, examining the Fe(III) sa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb9852db178218912be1aae8af3e7bb3
https://doi.org/10.1021/ol300173v
https://doi.org/10.1021/ol300173v
Autor:
William A. Carlezon, Cécile Béguin, Bruce M. Cohen, Thomas A. Munro, Lee-Yuan Liu-Chen, Wei Xu, Katharine K. Duncan, Douglas M. Ho
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1370-1380
In an effort to find novel agents which selectively target the kappa opioid receptor (KOPR), we modified the furan ring of the highly potent and selective KOPR agonist salvinorin A. Introduction of small substituents at C-16 was well tolerated. 12-ep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d67d2b021ac26fe8d49135f2351305
https://doi.org/10.1016/j.bmc.2008.12.012
https://doi.org/10.1016/j.bmc.2008.12.012
Autor:
Katharine K. Duncan, Bruce M. Cohen, Yulin Wang, Thomas A. Munro, Wei Xu, Lee-Yuan Liu-Chen, Cécile Béguin, William A. Carlezon
Publikováno v:
Bioorganic & Medicinal Chemistry. 16:1279-1286
Protection of salvinorin B as standard alkoxyalkyl ethers yielded highly potent kappa opioid receptor agonists. Ethoxymethyl ether 6 is among the most potent and selective kappa agonists reported to date. Fluoroethoxymethyl ether 11 is the first pote
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c512a95ef53dde9dd3542bf6673bef50
https://doi.org/10.1016/j.bmc.2007.10.067
https://doi.org/10.1016/j.bmc.2007.10.067