Výsledky vyhledávání - "Katharine E. Armour"

Growth of C57Bl/6 Mice and the Material and Mechanical Properties of Cortical Bone from the Tibia

Autor: Kenneth J. Armour, David M. Reid, Richard M. Aspden, Katharine E. Armour, J. M. Somerville

Publikováno v: Calcified Tissue International. 74:469-475

Murine models are becoming increasingly important for studying skeletal growth and regulation because of the relative ease with which their genomes can be manipulated. This study measured the changes in cortical bone of tibiae from one of the more co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e3838a750b58907aed2b3bcf20c3b49
https://doi.org/10.1007/s00223-003-0101-x

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Defective Bone Formation and Anabolic Response to Exogenous Estrogen in Mice with Targeted Disruption of Endothelial Nitric Oxide Synthase**This study was supported by grants from the Arthritis Research Campaign (UK) and the Medical Research Council (UK)

Autor: Marie E. Gallagher, Katharine E. Armour, Kenneth J. Armour, David M. Reid, Axel Gödecke, Miep H. Helfrich, Stuart H. Ralston

Publikováno v: Endocrinology. 142:760-766

Nitric oxide (NO) is a pleiotropic signaling molecule that is produced by bone cells constitutively and in response to diverse stimuli such as proinflammatory cytokines, mechanical strain, and sex hormones. Endothelial nitric oxide synthase (eNOS) is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::de24330339f9eff1c69ceaa6428ab4cc
https://doi.org/10.1210/endo.142.2.7977

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Inhibition of bone resorption in vitro and prevention of ovariectomy-induced bone loss in vivo by flurbiprofen nitroxybutylester (HCT1026)

Autor: Stuart H. Ralston, Katharine E. Armour, Rob van't Hof, Anne C. Torbergsen, Piero Del Soldato, Kenneth J. Armour

Publikováno v: Arthritis & Rheumatism. 44:2185-2192

Objective. Inhibitors of prostaglandin production, such as nonsteroidal antiinflammatory drugs (NSAIDs), and pharmacologic nitric oxide (NO) donors, such as organic nitrates, have been suggested to protect against bone loss in both humans and experim

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bd0aa569e410b2c5d97e3abab01e74bd
https://doi.org/10.1002/1529-0131(200109)44:9<2185::aid-art372>3.0.co

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Activation of the inducible nitric oxide synthase pathway contributes to inflammation-induced osteoporosis by suppressing bone formation and causing osteoblast apoptosis

Autor: David M. Reid, Stuart H. Ralston, Kenneth J. Armour, Xiao-Qing Wei, Foo Y. Liew, Rob van't Hof, Katharine E. Armour

Publikováno v: Arthritis & Rheumatism. 44:2790-2796

Objective. Osteoporosis is a major clinical problem in chronic inflammatory diseases such as rheumatoid arthritis. The mechanism of bone loss in this condition remains unclear, but previous studies have indicated that depressed bone formation plays a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::46b18af4a58d359944c179ad0b76dfb1
https://doi.org/10.1002/1529-0131(200112)44:12<2790::aid-art466>3.0.co

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Evidence for a Pathogenic Role of Nitric Oxide in Inflammation-Induced Osteoporosis

Autor: Katharine E. Armour, Peter Grabowski, David M. Reid, Rob van't Hof, Stuart H. Ralston

Publikováno v: Journal of Bone and Mineral Research. 14:2137-2142

Inflammatory disease is associated with increased production of nitric oxide (NO) and activation of the inducible nitric oxide synthase (iNOS) pathway. Several studies have addressed the role of NO as a mediator of cytokine effects on bone cell activ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4f97179a51289d811d85cc7fbcdfe84
https://doi.org/10.1359/jbmr.1999.14.12.2137

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Inflammation-Induced Osteoporosis: The IMO Model

Autor: Katharine E. Armour, Kenneth J. Armour

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fb72c46ae5760ef1188d42bed2fe9f0d
https://doi.org/10.1385/1-59259-366-6:353

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Inflammation-induced osteoporosis. The IMO model

Autor: Kenneth J, Armour, Katharine E, Armour

Publikováno v: Methods in molecular medicine. 80

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f29059eaa1ff9dfe52ccfae34de28342
https://pubmed.ncbi.nlm.nih.gov/12728730

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Potent Inhibitory Efects of a NO-NSAID (Flurbiprofen Nitroxybutylester) on Bone Resorption in Vitro and in Vivo

Autor: S.H. Ralston, Kenneth J. Armour, P. Del Soldato, R. J. van ’t Hof, Katharine E. Armour

Publikováno v: Advances in Prostaglandin and Leukotriene Research ISBN: 9789048158812

Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely employed in the treatment of musculoskeletal disorders but their use is limited by adverse effects on the gastrointestinal tract. A new class of NSAIDs, containing a nitric oxide (NO)-donor moi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e738f844088b4985bd4f581a936dbc1b
https://doi.org/10.1007/978-94-015-9721-0_34

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Requirement of the inducible nitric oxide synthase pathway for IL-1-induced osteoclastic bone resorption

Autor: Foo Y. Liew, R. J. van't Hof, L. M Smith, Kenneth J. Armour, Xiao-Qing Wei, Katharine E. Armour, Stuart H. Ralston

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America. 97(14)

Nitric oxide has been suggested to be involved in the regulation of bone turnover, especially in pathological conditions characterized by release of bone-resorbing cytokines. The cytokine IL-1 is thought to act as a mediator of periarticular bone los

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e2f72121eb64cc8c6e87929080befc0
https://pubmed.ncbi.nlm.nih.gov/10869429

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