Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Katharine Cain"'
Autor:
Linghong Huang, Helene Bon, Mabrouka Maamra, Toby Holmes, John Atkinson, Katharine Cain, Jeff Kennedy, Catherine Kettleborough, David Matthews, Breda Twomey, Jia Ni, Zhizhan Song, Philip F Watson, Timothy S Johnson
Publikováno v:
PLoS ONE, Vol 19, Iss 5, p e0298864 (2024)
Fibrotic remodeling is the primary driver of functional loss in chronic kidney disease, with no specific anti-fibrotic agent available for clinical use. Transglutaminase 2 (TG2), a wound response enzyme that irreversibly crosslinks extracellular matr
Externí odkaz:
https://doaj.org/article/7737e1a42d454e9d95b052f6ac871f2f
Autor:
Mabrouka Maamra, Osama Mehdi Benayad, David Matthews, Catherine Kettleborough, John Atkinson, Katharine Cain, Helene Bon, Helen Brand, Michael Parkinson, Philip F. Watson, Timothy S. Johnson
Publikováno v:
British Journal of Pharmacology. 179:2697-2712
Transglutaminase type 2 (TG2) catalyses formation of ε-(γ-glutamyl)-lysine bonds between proteins, including those of the extracellular matrix (ECM). Elevated extracellular TG2 leads to accelerated ECM deposition and reduced clearance that underlie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11ffde6501784ba28bc99a3b97d7f626
https://doi.org/10.1111/bph.15774
https://doi.org/10.1111/bph.15774
Autor:
Daniel Stöppler, Alex Macpherson, Susanne Smith-Penzel, Nicolas Basse, Fabien Lecomte, Hervé Deboves, Richard D Taylor, Tim Norman, John Porter, Lorna C Waters, Marta Westwood, Ben Cossins, Katharine Cain, James White, Robert Griffin, Christine Prosser, Sebastian Kelm, Amy H Sullivan, David Fox, Mark D Carr, Alistair Henry, Richard Taylor, Beat H Meier, Hartmut Oschkinat, Alastair D Lawson
Publikováno v:
PLoS Biology, Vol 16, Iss 5, p e2006192 (2018)
Aiming at the design of an allosteric modulator of the neonatal Fc receptor (FcRn)-Immunoglobulin G (IgG) interaction, we developed a new methodology including NMR fragment screening, X-ray crystallography, and magic-angle-spinning (MAS) NMR at 100 k
Externí odkaz:
https://doaj.org/article/8aa07cda1edf4eacba469577557c2556
Publikováno v:
Wellcome Open Research, Vol 2 (2017)
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR). This stress response results in expansion of the ER, upregulation of proteins involved in
Externí odkaz:
https://doaj.org/article/60df554dcc1048e4992d7865237ae174
Publikováno v:
Antibodies, Vol 3, Iss 3, Pp 253-271 (2014)
Reduced culture temperature is an increasingly popular practice to improve recombinant protein yields in CHO cells. Recent studies have attributed the enhancement of protein titers at sub-physiological temperatures to increased mRNA levels as well as
Externí odkaz:
https://doaj.org/article/e1696363564f4c958a6874c313c28a01
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0120096 (2015)
The isolation of stably transfected cell lines suitable for the manufacture of biotherapeutic protein products can be an arduous process relying on the identification of a high expressing clone; this frequently involves transgene amplification and ma
Externí odkaz:
https://doaj.org/article/eeb884e63d54447fa71ce22f9f195b25
Autor:
Oliver Zaccheo, Hanna Hailu, Shirley Jane Peters, Frank R. Brennan, Eleanor J. Ward, Rona M. Cutler, Andrew M. Ventom, Nicola L. Davies, David P. Humphreys, Farnaz Fallah-Arani, Thomas L. Pither, Tania F. Rowley, Gianluca Fossati, Louise J. Healy, Joshua M. Sopp, Mike Aylott, Katharine Cain, Alison Eddleston, John Sherington, Robert J. Griffin
Publikováno v:
Communications Biology, Vol 1, Iss 1, Pp 1-12 (2018)
Autoantibody-mediated diseases are currently treated with intravenous immunoglobulin, which is thought to act in part via blockade of Fc gamma receptors, thereby inhibiting autoantibody effector functions and subsequent pathology. We aimed to develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5549f806a17d958b41fae45c108dfc14
http://link.springer.com/article/10.1038/s42003-018-0149-9
http://link.springer.com/article/10.1038/s42003-018-0149-9
Autor:
Kevin Greenslade, H Björkelund, Alison Eddleston, Bryan Smith, Jay Tibbitts, S Crilly, F Junker, Michael D.J. Parkinson, Andrea Kiessling, Robert J. Griffin, Joanne E. Compson, Katharine Cain, Omar Qureshi, Frank R. Brennan, David P. Humphreys, Shirley Jane Peters, Farnaz Fallah-Arani, M Malmqvist, Louis Christodoulou, Nicola L. Davies, L Staelens, E. Ward, Tania F. Rowley, Thomas L. Pither
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-15 (2017)
Scientific Reports
Scientific Reports
Engagement of Fcγ-receptors triggers a range of downstream signalling events resulting in a diverse array of immune functions. As a result, blockade of Fc-mediated function is an important strategy for the control of several autoimmune and inflammat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43e1faf68f03085329d981162044eebb
http://link.springer.com/article/10.1038/s41598-017-17255-8
http://link.springer.com/article/10.1038/s41598-017-17255-8
Publikováno v:
Wellcome Open Research
Background: The mammalian endoplasmic reticulum (ER) continuously adapts to the cellular secretory load by the activation of an unfolded protein response (UPR). This stress response results in expansion of the ER, upregulation of proteins involved in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb9ed5c3c400a1b7126c77d15638a18
https://pubmed.ncbi.nlm.nih.gov/29062910
https://pubmed.ncbi.nlm.nih.gov/29062910
Autor:
Lindsay K. Shuttleworth, Andrew J. Beavil, Amanda K. F. Oxbrow, Alistair James Henry, Michael W-P Kao, James M. McDonnell, Benjamin P. Cossins, Jean Delgado, Hanna Hailu, Michael John Wright, Nyssa Drinkwater, Brian J. Sutton, Katharine Cain, Anthony H. Keeble
Publikováno v:
Nature structural & molecular biology
Crystallographic and solution studies have shown that IgE molecules are acutely bent in their Fc region. Crystal structures reveal the Cɛ2 domain pair folded back onto the Cɛ3-Cɛ4 domains, but is the molecule exclusively bent or can the Cɛ2 domai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4283914b99886c6d46916dd391611eab
http://europepmc.org/articles/PMC3977038
http://europepmc.org/articles/PMC3977038