Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Katharine Bray-French"'
Autor:
Laurent Larivière, Julia Eva Krüger, Thomas von Hirschheydt, Tilman Schlothauer, Katharine Bray-French, Martin Bader, Valeria Runza
Publikováno v:
International Journal of Pharmaceutics: X, Vol 5, Iss , Pp 100157- (2023)
Antibody-based T cell-activating biologics are promising therapeutic medicines being developed for a number of indications, mainly in the oncology field. Among those, T cell bispecific antibodies are designed to bind one tumor-specific antigen and th
Externí odkaz:
https://doaj.org/article/d1ba5ac8aaed4118ba1cd8be1b10c7e7
Autor:
Katharina Hartman, Guido Steiner, Michel Siegel, Cary M. Looney, Timothy P. Hickling, Katharine Bray-French, Sebastian Springer, Céline Marban-Doran, Axel Ducret
Publikováno v:
Biology, Vol 12, Iss 9, p 1265 (2023)
A critical step in the immunogenicity cascade is attributed to human leukocyte antigen (HLA) II presentation triggering T cell immune responses. The liquid chromatography–tandem mass spectrometry (LC-MS/MS)-based major histocompatibility complex (M
Externí odkaz:
https://doaj.org/article/60580742da114302a53620a33953db56
Autor:
Jerome Egli, Stefan Heiler, Felix Weber, Guido Steiner, Timo Schwandt, Katharine Bray-French, Christian Klein, Sebastian Fenn, Gregor P. Lotz, Eugenia Opolka-Hoffmann, Thomas E. Kraft, Laetitia Petersen, Rebecca Moser, Jonathan DeGeer, Michel Siegel, Daniela Finke, Juliana Bessa, Antonio Iglesias
Publikováno v:
mAbs, Vol 14, Iss 1 (2022)
Clinical anti-drug-antibody (ADA) responses represent a substantial obstacle to the development of efficacious therapeutic antibodies. The enhanced ADA production against the idiotype (Id) often displayed by cancer immunotherapy antibodies (CitAbs) c
Externí odkaz:
https://doaj.org/article/b365a7ae3054436e9a166bf9bbb165fe
Autor:
Michel Siegel, Guido Steiner, Linnea C. Franssen, Francesca Carratu, James Herron, Katharina Hartman, Cary M. Looney, Axel Ducret, Katharine Bray-French, Olivier Rohr, Timothy P. Hickling, Noel Smith, Céline Marban-Doran
Publikováno v:
Pharmaceutics, Vol 14, Iss 12, p 2672 (2022)
Immunogenicity, defined as the ability to provoke an immune response, can be either wanted (i.e., vaccines) or unwanted. The latter refers to an immune response to protein or peptide therapeutics, characterized by the production of anti-drug antibodi
Externí odkaz:
https://doaj.org/article/9163ac23f8bd4fae95f0bd210a951c5c
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Video 3. In vitro visualization of the dynamics of CD20-TCB (white) during interaction between CD8+ T-cells (green) and tumor cells (blue). The video focuses on an example of CD20-TCB-mediated CD8+ T-cell cytotoxicity of tumor cells. T-c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c34bb5766e137770cfc15b52be8812
https://doi.org/10.1158/1078-0432.22470684.v1
https://doi.org/10.1158/1078-0432.22470684.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Figure 1. Assessment of the binding characteristics and cynomolgus monkey cross-reactivity of CD20-TCB. Supplemental Figure 2. Tumor cell lysis mediated by different CD20-targeting TCB antibodies. Supplemental Figure 3. T-cell and B-cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c6f83b355ee080929db2938b3999bdc6
https://doi.org/10.1158/1078-0432.22470699.v1
https://doi.org/10.1158/1078-0432.22470699.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Video 1. In vitro visualization of the dynamics of untargeted TCB (white) during the interaction between CD8+ T-cells (green) and tumor cells (blue).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5528bbaeae8c4578de2abac8ea8e47c1
https://doi.org/10.1158/1078-0432.22470693.v1
https://doi.org/10.1158/1078-0432.22470693.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Purpose: Despite promising clinical activity, T-cell–engaging therapies including T-cell bispecific antibodies (TCB) are associated with severe side effects requiring the use of step-up-dosing (SUD) regimens to mitigate safety. Here, we present a n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::421e81a5be4c9af62b584bb4bcc20383
https://doi.org/10.1158/1078-0432.c.6527658
https://doi.org/10.1158/1078-0432.c.6527658
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental data details
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::257989830bf9a3ae734e9a5b265acd39
https://doi.org/10.1158/1078-0432.22470705.v1
https://doi.org/10.1158/1078-0432.22470705.v1
Autor:
Pablo Umaña, Christian Klein, Christiane Neumann, Laurent Lariviere, Anne Freimoser-Grundschober, Anna Maria Giusti, Heather Hinton, Katharine Bray-French, Wolfgang Richter, Tamara Hüsser, Ramona Schlenker, Florian Limani, Sarah Diggelmann, Valeria Nicolini, Anne Schoenle, Marine Richard, Roberta Bianchi, Stanford Chen, Mario Perro, Johannes Sam, Sylvia Herter, Sara Colombetti, Marina Bacac
Supplemental Video 2. In vitro visualization of the dynamics of CD20-TCB (white) during the interaction between CD8+ T-cells (green) and tumor cells (blue).
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74444c2ec5be11dba70eb0e8147dca27
https://doi.org/10.1158/1078-0432.22470690.v1
https://doi.org/10.1158/1078-0432.22470690.v1