Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Katharine A Whartenby"'
Autor:
Itzy E Morales Pantoja, Matthew D Smith, Labchan Rajbhandari, Linzhao Cheng, Yongxing Gao, Vasiliki Mahairaki, Arun Venkatesan, Peter A Calabresi, Kathryn C Fitzgerald, Katharine A Whartenby
Publikováno v:
PLoS ONE, Vol 15, Iss 6, p e0233980 (2020)
Multiple sclerosis (MS) is an inflammatory and demyelinating disease of the central nervous system (CNS) that results in variable severities of neurodegeneration. The understanding of MS has been limited by the inaccessibility of the affected cells a
Externí odkaz:
https://doaj.org/article/575b8464d15d450992578ce877033aa5
Autor:
Jaime Gonzalez Cardona, Matthew D Smith, Jingya Wang, Leslie Kirby, Jason T Schott, Todd Davidson, Jodi L Karnell, Katharine A Whartenby, Peter A Calabresi
Publikováno v:
PLoS ONE, Vol 14, Iss 9, p e0221747 (2019)
Multiple sclerosis (MS) is characterized by demyelinated lesions in the central nervous system. Destruction of myelin and secondary damage to axons and neurons leads to significant disability, particularly in people with progressive MS. Accumulating
Externí odkaz:
https://doaj.org/article/8c710515bfd64535a01b76fa9f35ddf6
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0139008 (2015)
Mesenchymal stem cells (MSCs) are pleiotropic cells with potential therapeutic benefits for a wide range of diseases. Because of their immunomodulatory properties they have been utilized to treat autoimmune diseases such as multiple sclerosis (MS), w
Externí odkaz:
https://doaj.org/article/6b8661163a224f3387b3af8948a9ae19
Autor:
Lina Hu, Tongguang Wang, Anne R Gocke, Avindra Nath, Hao Zhang, Joseph B Margolick, Katharine A Whartenby, Peter A Calabresi
Publikováno v:
PLoS ONE, Vol 8, Iss 1, p e54267 (2013)
Increased expression of the voltage-gated potassium channel Kν1.3 on activated effector memory T cells (T(EM)) is associated with pathology in multiple sclerosis (MS). To date, most studies of Kν1.3 channels in MS have focused on CD4+ T(EM) cells.
Externí odkaz:
https://doaj.org/article/b1b3d33c05f240149ec6d3c82d1de096
Autor:
Jing Jin, Alyssa Chao, Keya Meyers, Donald J. Zack, Claudia Kemper, Peter A. Calabresi, Joan Ohayon, Daniel S. Reich, Katharine A. Whartenby, Michelle Taylor, Thomas Garton, Marjan Gharagozloo, Carlos A. Pardo, Michael D. Kornberg, Brent A. Calabresi, Matthew D. Smith, Charles G. Eberhart
Publikováno v:
Acta Neuropathol
Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS) characterized by varying degrees of secondary neurodegeneration. Retinal ganglion cells (RGC) are lost in MS in association with optic neuritis but t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb4bb62e089e0da96e5386cb1f0d7535
https://doi.org/10.1007/s00401-021-02366-4
https://doi.org/10.1007/s00401-021-02366-4
Autor:
Irina A. Antonijevic, Brian R. Bettencourt, Peter Bialek, Pei Ge, Shi-Ying Ding, George Lai, Joseph Hedde, Eva Asp, Meetu Seth, George Marnellos, Katharine A. Whartenby, Darren G. Monckton, Sarah J. Tabrizi
Huntington disease (HD) is one of a growing number of rare genetic diseases characterized by the inheritance of an increased number of short tandem repeats within the affected gene. Many of these repeat expansion disorders (REDs) affect the brain. Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7eb4d0a6d166957fe956c4e881986c53
https://eprints.gla.ac.uk/269853/1/269853.pdf
https://eprints.gla.ac.uk/269853/1/269853.pdf
Autor:
Katharine A. Whartenby, Nicholas Fioravante, Ari J. Green, Sean A Aston, Ellen M. Mowry, Shiv Saidha, Gary Cutter, Stacey S. Cofield, Sergio E. Baranzini, Peter A. Calabresi, Dorlan J. Kimbrough, Alissa Rothman, Kicheol Kim, Kathryn C. Fitzgerald, Matthew D. Smith, Stephen Krieger, Fred D. Lublin, Pavan Bhargava, Philip L. De Jager
Publikováno v:
Brain
Multiple sclerosis is a heterogeneous disease with an unpredictable course and a wide range of severity; some individuals rapidly progress to a disabled state whereas others experience only mild symptoms. Though genetic studies have identified varian
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f289219f8786a6fb98c1677f0391fb5
https://doi.org/10.1093/brain/awz188
https://doi.org/10.1093/brain/awz188
Publikováno v:
Journal of Leukocyte Biology. 105:829-841
Myeloid-derived suppressor cells (MDSCs) are a diverse group of cells that are recognized for their remarkable suppressive effects on pro-inflammatory T cells. The pleiotropic nature of these cells, however, has been demonstrated by their differentia
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91179e72698f6b5edcf1abb78bd2673a
https://doi.org/10.1002/jlb.4hi0818-335r
https://doi.org/10.1002/jlb.4hi0818-335r
Autor:
Vasiliki Mahairaki, Peter C. Searson, Linzhao Cheng, Katharine A. Whartenby, Piotr Walczak, Peter A. Calabresi, Chengyan Chu, Max I. Bogorad, Zinnia S. Xu, Alanna M. Farrell, Raleigh M. Linville, Jackson G. DeStefano, Matt B. Sklar
Publikováno v:
Biomaterials. :24-37
Microvessels of the blood-brain barrier (BBB) regulate transport into the brain. The highly specialized brain microvascular endothelial cells, a major component of the BBB, express tight junctions and efflux transporters which regulate paracellular a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::88a1e684ac6a932d9478f1f68844734d
https://doi.org/10.1016/j.biomaterials.2018.10.023
https://doi.org/10.1016/j.biomaterials.2018.10.023
Autor:
Xitiz Chamling, Donald J. Zack, Zhicheng Ji, Itzy E. Morales Pantoja, Aniruddha M. Kaushik, Matthew D. Smith, Prajwal Devkota, Cynthia A. Berlinicke, Tza-Huei Wang, Joseph L. Mertz, Katharine A. Whartenby, Calvin Chang, Hongkai Ji, Weixiang Fang, Peter A. Calabresi, Liben Chen, Alyssa Kallman, Hai-Quan Mao
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Injury and loss of oligodendrocytes can cause demyelinating diseases such as multiple sclerosis. To improve our understanding of human oligodendrocyte development, which could facilitate development of remyelination-based treatment strategies, here w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738144e23ce1f2f4de5e51aed4116785
https://doi.org/10.1038/s41467-021-20892-3
https://doi.org/10.1038/s41467-021-20892-3