Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Katharina Stenzel"'
Autor:
Andrew John Hanton, Fiona Scott, Katharina Stenzel, Norman Nausch, Grace Zdesenko, Takafira Mduluza, Francisca Mutapi
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010536 (2022)
Cytokines mediate T-helper (TH) responses that are crucial for determining the course of infection and disease. The expression of cytokines is regulated by transcription factors (TFs). Here we present the frequencies of single nucleotide polymorphism
Externí odkaz:
https://doaj.org/article/95dadd59ebfd46b2bfaba2a39c653797
Autor:
Yevgeniya Antonova-Koch, Andrea Schöler, Tamirat Gebru, Finn K. Hansen, Vicky M. Avery, Thomas Kurz, Daniela Diedrich, Eva Hesping, Jana Held, Elizabeth A. Winzeler, Katharina Stenzel, Sandra Duffy, Stephan Meister, Gillian M. Fisher, Katherine T. Andrews
Publikováno v:
European Journal of Medicinal Chemistry. 158:801-813
Malaria drug discovery has shifted from a focus on targeting asexual blood stage parasites, to the development of drugs that can also target exo-erythrocytic forms and/or gametocytes in order to prevent malaria and/or parasite transmission. In this w
Autor:
Thomas Kurz, Finn K. Hansen, Fangyuan Cao, Alexandra Hamacher, Katharina Stenzel, Viktoria Krieger, Holger Gohlke, Linda Schäker-Hübner, Christoph G. W. Gertzen, Matthias U. Kassack, Frank J. Dekker
Publikováno v:
Journal of Medicinal Chemistry, 62(24), 11260-11279. AMER CHEMICAL SOC
There is increasing evidence that histone deacetylase (HDAC) inhibitors can (re)sensitize cancer cells for chemotherapeutics via "epigenetic priming". In this work, we describe the synthesis of a series of class I-selective HDAC inhibitors with 2-ami
Autor:
Sandra Duffy, Finn K. Hansen, Yevgeniya Antonova-Koch, Matthias U. Kassack, Elizabeth A. Winzeler, Ming Jang Chua, Katherine T. Andrews, Stephan Meister, Alexandra Hamacher, Katharina Stenzel, Thomas Kurz, Vicky M. Avery
Publikováno v:
ChemMedChem. 12(19)
In this work we aimed to develop parasite-selective histone deacetylase inhibitors (HDAC) inhibitors with activity against the disease-causing asexual blood stages of Plasmodium as well as causal prophylactic and/or transmission blocking properties.
Autor:
Katharina, Stenzel, Alokta, Chakrabarti, Jelena, Melesina, Finn K, Hansen, Julien, Lancelot, Simon, Herkenhöhner, Beate, Lungerich, Martin, Marek, Christophe, Romier, Raymond J, Pierce, Wolfgang, Sippl, Manfred, Jung, Thomas, Kurz
Publikováno v:
Archiv der Pharmazie. 350(8)
Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has been recently identified as a new potential target for the treatment of schistosomiasis. A series of newly designed and synthesized alkoxyamide-based and hydrazide-based HDAC inhibitors were tes
Autor:
Finn K. Hansen, Christophe Romier, Linda Marek, Martin Marek, Manfred Jung, Christoph G. W. Gertzen, Johanna Senger, Katharina Stenzel, Viktoria Marquardt, Marc Remke, Thomas Kurz, Alexandra Hamacher, Holger Gohlke, Matthias U. Kassack
Publikováno v:
Journal of Medicinal Chemistry
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩
Journal of Medicinal Chemistry, American Chemical Society, 2017, 60 (13), pp.5334-5348. ⟨10.1021/acs.jmedchem.6b01538⟩
The synthesis and biological evaluation of potent hydroxamate-based dual HDAC1/6 inhibitors with modest HDAC6 preference and a novel alkoxyurea connecting unit linker region are described. The biological studies included the evaluation of antiprolife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fae45bc45d6f85c20596af1b3e2cbe58
https://hal.archives-ouvertes.fr/hal-03691179
https://hal.archives-ouvertes.fr/hal-03691179
Autor:
Stephan Meister, Linda Marek, Katharina Stenzel, Benjamin Mordmüller, Matthias U. Kassack, Vicky M. Avery, Sandra Duffy, Elizabeth A. Winzeler, Finn K. Hansen, Alexandra Hamacher, Subathdrage D. M. Sumanadasa, Thomas Kurz, Rebekka Schmetter, Katherine T. Andrews, Krystina Kuna
Publikováno v:
European Journal of Medicinal Chemistry. 82:204-213
In this work we investigated the antiplasmodial activity of a series of HDAC inhibitors containing an alkoxyamide connecting-unit linker region. HDAC inhibitor 1a (LMK235), previously shown to be a novel and specific inhibitor of human HDAC4 and 5, w
Autor:
Finn K. Hansen, Jelena Melesina, Julien Lancelot, Raymond J. Pierce, Beate Lungerich, Christophe Romier, Alokta Chakrabarti, Wolfgang Sippl, Katharina Stenzel, Thomas Kurz, Manfred Jung, Simon Herkenhöhner, Martin Marek
Publikováno v:
Archiv der Pharmazie. 350:1700096
Schistosoma mansoni histone deacetylase 8 (SmHDAC8) has been recently identified as a new potential target for the treatment of schistosomiasis. A series of newly designed and synthesized alkoxyamide-based and hydrazide-based HDAC inhibitors were tes
Autor:
Katharina Stenzel, Michel Fleck
Publikováno v:
Acta Crystallographica Section E Structure Reports Online. 60:m1470-m1472
The crystal structure of the title compound, {[Co(C2H5NO2)2(H2O)2]Cl2}n, is presented and compared with other compounds of glycine and MII chlorides. It contains CoO6 octahedra connected by glycine molecules into layers. The Co atoms lie on centres