Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Katharina Nora Steinitz"'
Autor:
Christian Lubich, Katharina Nora Steinitz, Brigitte Hoelbl, Thomas Prenninger, Pauline Maria van Helden, Markus Weiller, Birgit Maria Reipert
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Background and aimsHemophilia A is a severe bleeding disorder caused by the deficiency of functionally active coagulation factor VIII (FVIII). The induction of neutralizing anti-drug antibodies is a major complication in the treatment of hemophilia A
Externí odkaz:
https://doaj.org/article/1e39f338c08a413697c869e4dc98b02c
Autor:
Kate Nesbitt, Katharina Nora Steinitz, Birgit M. Reipert, Alice S. van Velzen, Paul Moorehead, Christine Hough, David Lillicrap, Maria Schuster, Maria T. Georgescu
Publikováno v:
Haematologica, 103(8), 1403-1413. Ferrata Storti Foundation
Haematologica
Haematologica
The development of inhibitory antibodies to factor VIII is the most serious complication of replacement therapy in hemophilia A. Activation of the innate immune system during exposure to this protein contributes to inhibitor development. However, avo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa0b4c50cdf2fb3c8d986c7ec9d413e
https://pure.amc.nl/en/publications/dexamethasone-promotes-durable-factor-viiispecific-tolerance-in-hemophilia-a-mice-via-thymic-mechanisms(5cff90a1-e722-419f-a1e0-067bc16d2484).html
https://pure.amc.nl/en/publications/dexamethasone-promotes-durable-factor-viiispecific-tolerance-in-hemophilia-a-mice-via-thymic-mechanisms(5cff90a1-e722-419f-a1e0-067bc16d2484).html
Publikováno v:
Haemophilia. 21:300-306
The pharmacokinetics (PK) of extended half-life factor VIII (FVIII) products might allow longer dosing intervals in prophylaxis, potentially affecting its efficacy. We used published population PK models of a recombinant full-length FVIII (rAHF-PFM)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50e26d3519c612d2019b059935e9297a
https://doi.org/10.1111/hae.12605
https://doi.org/10.1111/hae.12605
Autor:
Katharina Nora Steinitz, Sergio Iannazzo, Alessandro Gringeri, Paolo Cortesi, Roberto Crea, Lorenzo G. Mantovani
The objective of this study was to assess the cost-effectiveness of pharmacokinetic-driven prophylaxis in severe haemophilia A patients. A microsimulation model was developed to evaluate the cost-effectiveness of pharmacokinetic-driven prophylaxis vs
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e60a59e94a19afcccc356233c2e1e5b
http://hdl.handle.net/10281/149251
http://hdl.handle.net/10281/149251
Autor:
P. M. W. Van Helden, Hans-Peter Prof. Schwarz, Raffi Udin Ahmad, Sabine Unterthurner, B.M. Reipert, Maria Schuster, J. Ilas, Katharina Nora Steinitz
Publikováno v:
Journal of Thrombosis and Haemostasis. 7:92-97
MHC class II molecules are essential for shaping the CD4+ T-cell repertoire in the thymus and for selecting antigenic peptides that are presented to CD4+ T cells in the periphery. A range of different mouse models humanized for HLA class II antigens
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eda60e2a24a994ba959be6fc51d91bfe
https://doi.org/10.1111/j.1538-7836.2009.03403.x
https://doi.org/10.1111/j.1538-7836.2009.03403.x
Autor:
Kate Sponagle, Jesse D. Lai, Christine Hough, Birgit M. Reipert, Paul Moorehead, Katharina Nora Steinitz, David Lillicrap
Publikováno v:
Blood. 127(26)
Inflammatory signals such as pathogen- and danger-associated molecular patterns have been hypothesized as risk factors for the initiation of the anti-factor VIII (FVIII) immune response seen in 25% to 30% of patients with severe hemophilia A (HA). In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b1ac16246e4a5c120c6b6ff21d59cd
https://pubmed.ncbi.nlm.nih.gov/27034428
https://pubmed.ncbi.nlm.nih.gov/27034428
Autor:
Birgit M. Reipert, Katharina Nora Steinitz, Hans Peter Schwarz, David C. Wraith, Pauline M. van Helden, Markus Weiller, Maurus de la Rosa, Rafi U. Ahmad, Maria Schuster, Corinna Hermann, Brigitte Binder, Sabine Unterthurner, Christian Lubich
Publikováno v:
Blood. 119(17)
Today it is generally accepted that B cells require cognate interactions with CD4+ T cells to develop high-affinity antibodies against proteins. CD4+ T cells recognize peptides (epitopes) presented by MHC class II molecules that are expressed on anti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e177832e23a8ee6284f8ad76ed51beb
https://pubmed.ncbi.nlm.nih.gov/22394599
https://pubmed.ncbi.nlm.nih.gov/22394599
Autor:
Frank M. Horling, Birgit M. Reipert, Hans-Peter Schwarz, Katharina Nora Steinitz, Christoph J. Hofbauer
Publikováno v:
Current and Future Issues in Hemophilia Care
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7820c36f41d479a5af09f5f3b48b9d86
https://doi.org/10.1002/9781119979401.ch12
https://doi.org/10.1002/9781119979401.ch12
Autor:
Alessandro Gringeri, Katharina Nora Steinitz, Paolo Cortesi, Matteo Rota, Lorenzo G. Mantovani, Armin J. Reininger
Publikováno v:
Blood. 126:289-289
Introduction. Recent large cohort studies have shown data on inhibitor incidence in previously untreated patients (PUPs) with hemophilia A treated with recombinant factor VIII concentrates (rFVIII), which disputed previous reports or clinical trials.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c5b8ec14c619dec35d48b05a4c03490
https://doi.org/10.1182/blood.v126.23.289.289
https://doi.org/10.1182/blood.v126.23.289.289
Autor:
David Lillicrap, Christine Hough, Barbara Vidal, Paul Moorehead, Maria T. Georgescu, Alice S. van Velzen, Birgit M. Reipert, Kate Sponagle, Katharina Nora Steinitz
Publikováno v:
Blood. 124:1489-1489
Background For persons with severe hemophilia A receiving exogenous factor VIII (FVIII) replacement therapy, antibodies that interfere with the coagulant function of FVIII (inhibitors) are the most severe complication of treatment. Although avoidance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9648a1b21b599b62ef9ab1995807e264
https://doi.org/10.1182/blood.v124.21.1489.1489
https://doi.org/10.1182/blood.v124.21.1489.1489