Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Katharina Mergel"'
Autor:
Hendrik Fuchs, Matthias F. Melzig, Burkhard Wiesner, Katharina Mergel, Mayank Thakur, Alexandra Pieper, Jenny Eichhorst, Benedicta von Mallinckrodt, Cornelia Görick, Roger Gilabert-Oriol, Alexander Weng
Publikováno v:
International Journal of Biological Macromolecules. 61:285-294
Macromolecular interaction of protein toxins with certain plant triterpenoids holds potential for application in tumor therapy. The ability of only certain saponins to enhance the endosomal escape of toxins specifically in tumor cells was evaluated a
Autor:
Mayank Thakur, Roger Gilabert-Oriol, Katharina Mergel, Matthias F. Melzig, Hendrik Fuchs, Benedicta von Mallinckrodt, Alexander Weng
Publikováno v:
Bioorganic & Medicinal Chemistry. 21:2387-2395
Saponins are a group of plant and marine derived glycosides with numerous biological functions. Two important characteristics of certain plant saponins are their ability to enhance cytotoxicity of type I ribosome inactivating proteins and stimulation
Autor:
Alexander Weng, Katharina Mergel, Mayank Thakur, Diana Bachran, Matthias F. Melzig, Roger Gilabert-Oriol, Stefanie Frech, Hendrik Fuchs
Publikováno v:
Biosensors and Bioelectronics. 35:503-506
This work describes the application of an impedance-based measurement for the real time evaluation of targeted tumor therapies in cell culture (HeLa cells). We used a treatment procedure that is well established in cells and mice. Therein, tumor cell
Autor:
Horst Dürkop, Alexander Weng, Hendrik Fuchs, Roger Gilabert-Oriol, Matthias F. Melzig, Mayank Thakur, Katharina Mergel, Benedicta von Mallinckrodt
Publikováno v:
Molecular oncology. 7(3)
Targeted toxin-based therapeutics are hindered by poor intracellular uptake, limited stability and non-specific immune stimulation. To address these problems, ligand-targeted toxins in combination with low dose saponin mixtures have been adapted and