Dynamic immune cell recruitment after murine pulmonary Aspergillus fumigatus infection under different immunosuppressive regimens

Autor: Natarajaswamy Kalleda, Jorge Amich, Berkan Arslan, Spoorthi Poreddy, Katharina Mattenheimer, Zeinab Mokhtari, Hermann Einsele, Matthias Brock, Katrin Heinze, Andreas Beilhack

Publikováno v: Frontiers in Microbiology, Vol 7 (2016)

Humans are continuously exposed to airborne spores of the saprophytic fungus Aspergillus fumigatus. However, in healthy individuals pulmonary host defense mechanisms efficiently eliminate the fungus. In contrast, A. fumigatus causes devastating infec

Externí odkaz: https://doaj.org/article/7ae8c6ce5936405cbf2d85b00e70b128

Tumor necrosis factor induces tumor promoting and anti-tumoral effects on pancreatic cancer via TNFR1.

Autor: Martin Chopra, Isabell Lang, Steffen Salzmann, Christina Pachel, Sabrina Kraus, Carina A Bäuerlein, Christian Brede, Ana-Laura Jordán Garrote, Katharina Mattenheimer, Miriam Ritz, Stefanie Schwinn, Carolin Graf, Viktoria Schäfer, Stefan Frantz, Hermann Einsele, Harald Wajant, Andreas Beilhack

Publikováno v: PLoS ONE, Vol 8, Iss 9, p e75737 (2013)

Multiple activities are ascribed to the cytokine tumor necrosis factor (TNF) in health and disease. In particular, TNF was shown to affect carcinogenesis in multiple ways. This cytokine acts via the activation of two cell surface receptors, TNFR1, wh

Externí odkaz: https://doaj.org/article/ac81b820406a4aebb816b1c76c1495ef

JAM-A as a prognostic factor and new therapeutic target in multiple myeloma

Autor: Thorsten Stühmer, Martina Rudelius, Vanessa Desantis, Angelo Vacca, Zeinab Mokhtari, Anna Ruckdeschel, Paolo Trerotoli, Max Bittrich, Miriam Ritz, Andreas Rosenwald, Franz Jakob, H. Einsele, Regina Ebert, Antonio Giovanni Solimando, Julia Dotterweich, Andreas Beilhack, Carolin Graf, Andreas Brandl, Katharina Mattenheimer, Ma Frassanito

Publikováno v: Leukemia

Cell adhesion in the multiple myeloma (MM) microenvironment has been recognized as a major mechanism of MM cell survival and the development of drug resistance. Here we addressed the hypothesis that the protein junctional adhesion molecule-A (JAM-A)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c4b510ef47d1620ce773c94f2be253d
https://doi.org/10.1038/leu.2017.287

Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion

Autor: Rafaela Holtappels, Andrea Fick, Jeanette Baker, Harald Wajant, Matthias J. Reddehase, Thomas Müller, Daniela N. Männel, Andreas Brandl, Thorsten Winter, Viktoria Schäfer, Hermann Einsele, Carina A. Bäuerlein, Axel Seher, Jürgen Podlech, Sabrina Kraus, Johannes Polz, Eliana Ribechini, Tim Steinfatt, Sven Krappmann, Janina Kuen, Juliane Kums, Jorge Amich, Andreas Beilhack, Hidekazu Nishikii, Katja J. Ottmüller, Friederike Berberich-Siebelt, Anja Mottok, Manfred B. Lutz, Miriam Ritz, Ana-Laura Jordán-Garrote, Martin Vaeth, Katharina Mattenheimer, Christian Brede, Stefanie Schwinn, Martin Chopra, Marlene Biehl

Publikováno v: The Journal of Experimental Medicine
Chopra, M, Biehl, M, Steinfatt, T, Brandl, A, Kums, J, Amich Elias, J, Vaeth, M, Kuen, J, Holtappels, R, Podlech, J, Mottok, A, Kraus, S, Jordán-Garrote, A-L, Bäuerlein, C A, Brede, C, Ribechini, E, Fick, A, Seher, A, Polz, J, Ottmüller, K J, Baker, J, Nishikii, H, Ritz, M, Mattenheimer, K, Schwinn, S, Winter, T, Schäfer, V, Krappmann, S, Einsele, H, Müller, T D, Reddehase, M J, Lutz, M B, Männel, D N, Berberich-Siebelt, F, Wajant, H & Beilhack, A 2016, ' Exogenous TNFR2 activation protects from acute GvHD via host T reg cell expansion ', Journal of Experimental Medicine, vol. 213, no. 9, pp. 1881–1900 . https://doi.org/10.1084/jem.20151563

Activation of TNFR2 with a novel agonist expands T reg cells in vivo and protects allo-HCT recipients from acute GvHD while sparing antilymphoma and antiinfectious properties of transplanted donor T cells.
Donor CD4+Foxp3+ regulatory T cells (T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f6a4988c207afd66c5d8de16a6bb555
https://opus.bibliothek.uni-wuerzburg.de/frontdoor/index/index/docId/18764

Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis

Autor: Sabrina Kraus, Christian Brede, Viktoria von Krosigk, Andreas Beilhack, Anja Mottok, Harald Wajant, Katharina Mattenheimer, Martin Chopra, Marlene Biehl, Axelle Degla, Viktoria Schäfer, Carina A. Bäuerlein, Ana-Laura Jordán Garrote, Stefanie Krieger, Miriam Ritz, Simone S. Riedel, Hermann Einsele

Publikováno v: Carcinogenesis. 34(6)

The cytokine tumor necrosis factor (TNF) has pleiotropic functions both in normal physiology and disease. TNF signals by the virtue of two cell surface receptors, TNF receptor 1 (TNFR1) and TNF receptor 2 (TNFR2). Exogenous TNF promotes experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce4efb168acfb636da854ba5f46abb36
https://pubmed.ncbi.nlm.nih.gov/23385062