Výsledky vyhledávání - "Katharina L. Kopp"

Akademický článek

CCL22-based peptide vaccines induce anti-cancer immunity by modulating tumor microenvironment

Autor: Inés Lecoq, Katharina L. Kopp, Marion Chapellier, Panagiotis Mantas, Evelina Martinenaite, Maria Perez-Penco, Lars Rønn Olsen, Mai-Britt Zocca, Ayako Wakatsuki Pedersen, Mads Hald Andersen

Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)

CCL22 is a macrophage-derived immunosuppressive chemokine that recruits regulatory T cells through the CCL22:CCR4 axis. CCL22 was shown to play a key role in suppressing anti-cancer immune responses in different cancer types. Recently, we showed that

Externí odkaz: https://doaj.org/article/4deb28186bcd4fa28e4ce8cd2df20145

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Akademický článek

Peptide vaccination directed against IDO1-expressing immune cells elicits CD8+ and CD4+ T-cell-mediated antitumor immunity and enhanced anti-PD1 responses

Autor: Mads Hald Andersen, Souvik Dey, Erika Sutanto-Ward, Katharina L Kopp, James DuHadaway, Arpita Mondal, Dema Ghaban, Inés Lecoq, Mai-Britt Zocca, Lauren M F Merlo, Laura Mandik-Nayak, Ayako Wakatsuki Pedersen, Alexander J Muller

Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

Background The tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpre

Externí odkaz: https://doaj.org/article/85b92312e7ef499e81e377e49eedf1d5

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Arginase 1-Based Immune Modulatory Vaccines Induce Anticancer Immunity and Synergize with Anti-PD-1 Checkpoint Blockade

Autor: Evelina Martinenaite, Annalisa Adamo, Stine Emilie Weis-Banke, Katharina L. Kopp, Maria Perez-Penco, Stefano Ugel, Marion Chapellier, Vincenzo Bronte, Mie Linder Hübbe, Cristina Frusteri, Marco Carretta, Mia Aaboe Jørgensen, Mai-Britt Zocca, Francesco De Sanctis, Ayako Wakatsuki Pedersen, Manuela Iezzi, Mads Hald Andersen, Daniel Hargbøll Madsen

Publikováno v: Cancer immunology research. 9(11)

Expression of the L-arginine catabolizing enzyme arginase 1 (ARG1) is a central immunosuppressive mechanism mediated by tumor-educated myeloid cells. Increased activity of ARG1 promotes the formation of an immunosuppressive microenvironment and leads

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f5c10fa0f3c105df278cfbbbc391be1
https://pubmed.ncbi.nlm.nih.gov/34518197

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P04.03 Immune modulatory vaccine directed against IDO1-expressing immune cells elicits T cell-mediated anti-tumor immunity and enhances anti-PD1 responses

Autor: Souvik Dey, Inés Lecoq, James B. DuHadaway, Erika Sutanto-Ward, Arpita Mondal, Katharina L. Kopp, Mads Hald Andersen, Mai-Britt Zocca, Alexander J. Muller, Ayako Wakatsuki Pedersen

Publikováno v: E-Poster Presentations.

Background Indoleamine 2,3-dioxygenase 1 (IDO1) is a tryptophan-catabolizing enzyme that contributes to immunoregulation at many levels, including suppressing effector T cells and inducing/activating regulatory T cells. Thus far, several therapeutic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2787faf39848416d2b529c292ca086c3
https://doi.org/10.1136/jitc-2020-itoc7.72

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P09.07 An immune modulatory vaccine targeting CCL22 promotes anti-tumor immunity

Autor: R Christensen, Ayako Wakatsuki Pedersen, Inés Lecoq, Katharina L. Kopp, Mads Hald Andersen, Evelina Martinenaite

Publikováno v: E-Poster Presentations.

Background CCL22 is a macrophage-derived chemokine that exerts immunosuppressive functions by the recruitment of regulatory T cells (Treg) through the CCL22/CCR4 axis. It has been described to play a key role in the suppression of anti-cancer immunit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0e5c9f82c9aad77799374ecc354c315b
https://doi.org/10.1136/jitc-2020-itoc7.107

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Peptide vaccination directed against IDO1-expressing immune cells elicits CD8

Autor: Souvik, Dey, Erika, Sutanto-Ward, Katharina L, Kopp, James, DuHadaway, Arpita, Mondal, Dema, Ghaban, Inés, Lecoq, Mai-Britt, Zocca, Lauren M F, Merlo, Laura, Mandik-Nayak, Mads Hald, Andersen, Ayako Wakatsuki, Pedersen, Alexander J, Muller

Publikováno v: Journal for Immunotherapy of Cancer

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::e9b602e1823a90d97acfe785b648e7fd
https://pubmed.ncbi.nlm.nih.gov/32690770

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Peptide vaccination directed against IDO1-expressing immune cells elicits CD8 + and CD4 + T-cell-mediated antitumor immunity and enhanced anti-PD1 responses

Autor: James B. DuHadaway, Erika Sutanto-Ward, Dema Ghaban, Lauren M.F. Merlo, Arpita Mondal, Mads Hald Andersen, Ayako Wakatsuki Pedersen, Laura Mandik-Nayak, Souvik Dey, Katharina L. Kopp, Inés Lecoq, Alexander J. Muller, Mai-Britt Zocca

Publikováno v: Dey, S, Sutanto-Ward, E, Kopp, K L, Duhadaway, J, Mondal, A, Ghaban, D, Lecoq, I, Zocca, M B, Merlo, L M F, Mandik-Nayak, L, Andersen, M H, Pedersen, A W & Muller, A J 2020, ' Peptide vaccination directed against IDO1-expressing immune cells elicits CD8 + and CD4 + T-cell-mediated antitumor immunity and enhanced anti-PD1 responses ', Journal for ImmunoTherapy of Cancer, vol. 8, no. 2, 2020000605 . https://doi.org/10.1136/jitc-2020-000605
Journal for ImmunoTherapy of Cancer, Vol 8, Iss 2 (2020)

BackgroundThe tryptophan-catabolizing enzyme indoleamine 2,3-dioxygenase 1 (IDO1), which subverts T-cell immunity at multiple levels, is itself subject to inherent T-cell reactivity. This intriguing deviation from central tolerance has been interpret

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24213c5586cc584ecdd188e8c7c16e98
https://curis.ku.dk/ws/files/258770834/e000605.full.pdf

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Malignant T cells express lymphotoxin α and drive endothelial activation in cutaneous T cell lymphoma

Autor: Mariusz A. Wasik, Lars Jønson, Charlotte M. Bonefeld, Lise Mette Rahbek Gjerdrum, Elisabeth Ralfkiaer, Niels Ødum, Ulrik Ralfkiaer, Anders Woetmann, Katharina L. Kopp, Carsten Geisler, Qian Zhang, Sally Dabelsteen, Louise Christensen, Britt Lauenborg

Publikováno v: Oncotarget
Europe PubMed Central
Scopus-Elsevier

// Britt Lauenborg 1 , Louise Christensen 1 , Ulrik Ralfkiaer 2 , Katharina L. Kopp 1 , Lars Jonson 3 , Sally Dabelsteen 4 , Charlotte M. Bonefeld 1 , Carsten Geisler 1 , Lise Mette R. Gjerdrum 5 , Qian Zhang 6 , Mariusz A. Wasik 6 , Elisabeth Ralfki

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b8cc68222a72b8dc66e12e946298691
http://europepmc.org/articles/PMC4558148

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Abstract 5020: Therapeutic potential of an immune modulatory CCL22-based vaccine

Autor: Rikke Christensen, Mads Hald Andersen, Evelina Martinenaite, Mai-Britt Zocca, Inés Lecoq, Ayako Wakatsuki Pedersen, Katharina L. Kopp

Publikováno v: Cancer Research. 79:5020-5020

CCL22 is a macrophage-derived chemokine that exerts immunosuppressive functions by the recruitment of regulatory T cells (Tregs) through the CCL22/CCR4 axis. It is expressed by cells in the tumor microenvironment (TME) in many different cancer tissue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36dcc2a207d8b5a79e6df13f931a28e0
https://doi.org/10.1158/1538-7445.am2019-5020

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SATB1 in Malignant T Cells

Publikováno v: Fredholm, S, Willerslev-Olsen, A, Met, Ö, Kubat, L, Gluud, M, Mathiasen, S L, Friese, C, Blümel, E, Petersen, D L, Hu, T, Nastasi, C, Lindahl, L M, Buus, T B, Krejsgaard, T, Wasik, M A, Kopp, K L, Koralov, S B, Persson, J L, Bonefeld, C M, Geisler, C, Woetmann, A, Iversen, L, Becker, J C & Odum, N 2018, ' SATB1 in Malignant T Cells ', Journal of Investigative Dermatology, vol. 138, no. 8, pp. 1805-1815 . https://doi.org/10.1016/j.jid.2018.03.1526

Deficient expression of Suppressor Special AT-rich Binding-1 (SATB1) hampers thymocyte development and results in inept T cell lineages. Recent data implicate dysregulated SATB1 expression in the pathogenesis of mycosis fungoides (MF), the most frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::112ee763f8d53195c47b2a8f72af91e0
https://pubmed.ncbi.nlm.nih.gov/30660670

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