Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Katharina L. Dürr"'
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
Here, Chi et al. report cryo-EM structures of the human Kv3.1a channel, revealing a unique arrangement of the cytoplasmic T1 domain, which allows the interactions with the C-terminal axonal targeting motif and key components of the gating machinery.
Externí odkaz:
https://doaj.org/article/3b1f137234894981ba29f62e3c7d792a
Autor:
Gamma Chi, Qiansheng Liang, Akshay Sridhar, John B. Cowgill, Kasim Sader, Mazdak Radjainia, Pu Qian, Pablo Castro-Hartmann, Shayla Venkaya, Nanki Kaur Singh, Gavin McKinley, Alejandra Fernandez-Cid, Shubhashish M. M. Mukhopadhyay, Nicola A. Burgess-Brown, Lucie Delemotte, Manuel Covarrubias, Katharina L. Dürr
Publikováno v:
Nature Communications
Kv3 channels have distinctive gating kinetics tailored for rapid repolarization in fast-spiking neurons. Malfunction of this process due to genetic variants in the KCNC1 gene causes severe epileptic disorders, yet the structural determinants for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f12c53a3703e4b32471ede4830f9bff
https://pubmed.ncbi.nlm.nih.gov/35840565
https://pubmed.ncbi.nlm.nih.gov/35840565
Autor:
Rebecca Ebenhoch, S.M.M. Mukhopadhyay, Samira Slimani, Henry Man, Gavin McKinley, Gabriella Reggiano, Patrizia Abrusci, Gamma Chi, Nicola A. Burgess-Brown, Kiran Bountra, Idlir Liko, Alexandre P. Garneau, Ben Tehan, Frank DiMaio, Katharina L. Dürr, Ali Jazayeri, Carol V. Robinson, Alejandra Fernández-Cid, Laurence E. Tremblay, Tina Bohstedt, Christophe P Moreau, Julie L. Lavoie, Xingyu Qiu, Haiping Tang, Dong Wang, Fernando G. Almeida, Paul Isenring
Publikováno v:
The EMBO Journal
'EMBO Journal ', vol: 40, pages: e107294-1-e107294-20 (2021)
EMBO J
'EMBO Journal ', vol: 40, pages: e107294-1-e107294-20 (2021)
EMBO J
Potassium-coupled chloride transporters (KCCs) play crucial roles in regulating cell volume and intracellular chloride concentration. They are characteristically inhibited under isotonic conditions via phospho-regulatory sites located within the cyto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3901c064e34846dc7faf110fe142fdee
https://doi.org/10.15252/embj.2020107294
https://doi.org/10.15252/embj.2020107294
Autor:
Henry Man, Nicola A. Burgess-Brown, Shubhashish M.M. Mukhopadhyay, Katherine J. Ellis, Alejandra Fernández-Cid, Pravin Mahajan, Katharina L. Dürr, Gamma Chi
Publikováno v:
Methods in Molecular Biology ISBN: 9781071608913
This chapter describes the step-by-step methods employed by the Structural Genomics Consortium (SGC) for screening and producing proteins in the BacMam system. This eukaryotic expression system was selected and a screening process established in 2016
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ccb4a2abb72410cca76ff3ab046dfd4
https://doi.org/10.1007/978-1-0716-0892-0_6
https://doi.org/10.1007/978-1-0716-0892-0_6
Autor:
Pravin, Mahajan, Katherine, Ellis, Shubhashish, Mukhopadhyay, Alejandra, Fernandez-Cid, Gamma, Chi, Henry, Man, Katharina L, Dürr, Nicola A, Burgess-Brown
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2199
This chapter describes the step-by-step methods employed by the Structural Genomics Consortium (SGC) for screening and producing proteins in the BacMam system. This eukaryotic expression system was selected and a screening process established in 2016
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::33ba2f2fb5a67b5489b54f1213d7e1d0
https://pubmed.ncbi.nlm.nih.gov/33125646
https://pubmed.ncbi.nlm.nih.gov/33125646
Publikováno v:
PLoS ONE, Vol 7, Iss 3, p e33645 (2012)
Whereas electrogenic partial reactions of the Na,K-ATPase have been studied in depth, much less is known about the influence of the membrane potential on the electroneutrally operating gastric H,K-ATPase. In this work, we investigated site-specifical
Externí odkaz:
https://doaj.org/article/5bc15a68e46149219fbe5fb5d9c0bacf
Publikováno v:
Science. 345:1021-1026
Activating a receptor to excite a neuron Transmitting signals between nerve cells, occuring at structures known as synapses, is critical to processes such as learning and memory. Fast transmission occurs when glutamate is released from a presynaptic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7111c1ae36bb3ab1cd0207d2585c2a8c
https://doi.org/10.1126/science.1258409
https://doi.org/10.1126/science.1258409
Autor:
Richard A. Stein, I. Mihaela Folea, Katharina L. Dürr, Eric Gouaux, Rita De Zorzi, Hassane S. Mchaourab, Lei Chen, Thomas Walz
Publikováno v:
Cell. 158(4):778-792
SummaryIonotropic glutamate receptors (iGluRs) mediate the majority of fast excitatory signaling in the nervous system. Despite the profound importance of iGluRs to neurotransmission, little is known about the structures and dynamics of intact recept
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e58a0f3aa977de9ee4211ff22e5ff8
Publikováno v:
Journal of Biological Chemistry. 284:20147-20154
The catalytic alpha-subunits of Na,K- and H,K-ATPase require an accessory beta-subunit for proper folding, maturation, and plasma membrane delivery but also for cation transport. To investigate the functional significance of the beta-N terminus of th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::050649a1d78853b7c106f2df902a3874
https://doi.org/10.1074/jbc.m109.005769
https://doi.org/10.1074/jbc.m109.005769
Publikováno v:
Journal of Biological Chemistry. 284:3842-3854
The beta-subunits of Na,K-ATPase and H,K-ATPase have important functions in maturation and plasma membrane targeting of the catalytic alpha-subunit but also modulate the transport activity of the holoenzymes. In this study, we show that tryptophan re
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fdc24e0eae88d7f56c9f87a6ade66a2
https://doi.org/10.1074/jbc.m808101200
https://doi.org/10.1074/jbc.m808101200