Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse

Autor: Satoshi Hirakawa, Katharina Krautgasser, Ingrid Raab, Felix Offner, Nicole Huttary, Brigitte Hantusch, Romana Kalt, Hitonari Nosaka, Katalin Nagy-Bojarszky, Susanne Wolbank, Klaus Kaserer, Michael Gnant, Katharina Viola, Sigurd Krieger, Helga Schachner, Sybille Madlener, Michael Detmar, Thomas Keller, Karin Lackner, Margaretha Rudas, Veronika Sexl, Martin Schreiber, Gregor Bartel, Thorsten J. Maier, Sandra Rezar, Georg Krupitza, Alexander Nader, Kari Alitalo, Agnes Davidovits, Sebastian M.B. Nijman, Dieter Steinhilber, Christine Schneckenleithner, Wolfgang Mikulits, Dontscho Kerjaschki, Zsuzsanna Bago-Horvath, Caroline Vonach, Monika Hämmerle, Helmut Dolznig

Publikováno v: Kerjaschki, D, Bago-Horvath, Z, Rudas, M, Sexl, V, Schneckenleithner, C, Wolbank, S, Bartel, G, Krieger, S, Kalt, R, Hantusch, B, Keller, T, Nagy-Bojarszky, K, Huttary, N, Raab, I, Lackner, K, Krautgasser, K, Schachner, H, Kaserer, K, Rezar, S, Madlener, S, Vonach, C, Davidovits, A, Nosaka, H, Hämmerle, M, Viola, K, Dolznig, H, Schreiber, M, Nader, A, Mikulits, W, Gnant, M, Hirakawa, S, Detmar, M, Alitalo, K, Nijman, S, Offner, F, Maier, T, Steinhilber, D & Krupitza, G 2011, ' Lipoxygenase mediates invasion of intrametastatic lymphatic vessels and propagates lymph node metastasis of human mammary carcinoma xenografts in mouse ', Journal of Clinical Investigation, vol. 121, no. 5, pp. 2000-12 . https://doi.org/10.1172/JCI44751

In individuals with mammary carcinoma, the most relevant prognostic predictor of distant organ metastasis and clinical outcome is the status of axillary lymph node metastasis. Metastases form initially in axillary sentinel lymph nodes and progress vi

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https://doi.org/10.1172/jci44751