Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Katharina Kasack"'
Autor:
Konstantin Helmsauer, Maria E. Valieva, Salaheddine Ali, Rocío Chamorro González, Robert Schöpflin, Claudia Röefzaad, Yi Bei, Heathcliff Dorado Garcia, Elias Rodriguez-Fos, Montserrat Puiggròs, Katharina Kasack, Kerstin Haase, Csilla Keskeny, Celine Y. Chen, Luis P. Kuschel, Philipp Euskirchen, Verena Heinrich, Michael I. Robson, Carolina Rosswog, Joern Toedling, Annabell Szymansky, Falk Hertwig, Matthias Fischer, David Torrents, Angelika Eggert, Johannes H. Schulte, Stefan Mundlos, Anton G. Henssen, Richard P. Koche
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
MYCN amplification is common in neuroblastomas. Here the authors analyse the MYCN amplicon structure and its epigenetic regulation by integrating short- and longread genomic and epigenomic data and find two classes of MYCN amplicons in neuroblastomas
Externí odkaz:
https://doaj.org/article/c5b9fcaacd9648e4831d4de98b3e2479
Autor:
Kathleen Klotz-Noack, Bertram Klinger, Maria Rivera, Natalie Bublitz, Florian Uhlitz, Pamela Riemer, Mareen Lüthen, Thomas Sell, Katharina Kasack, Bastian Gastl, Sylvia S.S. Ispasanie, Tincy Simon, Nicole Janssen, Matthias Schwab, Johannes Zuber, David Horst, Nils Blüthgen, Reinhold Schäfer, Markus Morkel, Christine Sers
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108184- (2020)
Summary: Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of BRAFV600E-driven cytoplasmic signaling networks has proved ineffective, as patients regularly r
Externí odkaz:
https://doaj.org/article/2950671e43df461fba99d304a2fcf743
Extrachromosomal DNA amplifications are common in cancer and are associated with decreased patient survival. A key feature of extrachromosomal circular DNA is its ability to be randomly mis-segregated to daughter cells promoting rapid intercellular h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fce7985b2908d42bff25af8c2f4ea604
https://doi.org/10.21203/rs.3.pex-2180/v1
https://doi.org/10.21203/rs.3.pex-2180/v1
Autor:
Rocío Chamorro González, Thomas Conrad, Maja C. Stöber, Robin Xu, Mădălina Giurgiu, Elias Rodriguez-Fos, Katharina Kasack, Lotte Brückner, Eric van Leen, Konstantin Helmsauer, Heathcliff Dorado Garcia, Maria E. Stefanova, King L. Hung, Yi Bei, Karin Schmelz, Marco Lodrini, Stefan Mundlos, Howard Y. Chang, Hedwig E. Deubzer, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Extrachromosomal DNAs (ecDNAs) are common in cancer, but many questions about their origin, structural dynamics and impact on intratumor heterogeneity are still unresolved. Here we describe single-cell extrachromosomal circular DNA and transcriptome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc99ed2c6257eafccfbc8313ccf81a41
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
http://edoc.mdc-berlin.de/23342/2/23342suppl.zip
Autor:
Rocio Chamorro Gonzalez, Thomas Conrad, Robin Xu, Madalina Giurgiu, Maja Cwikla, Katharina Kasack, Lotte Brückner, Eric van Leen, Elias Rodriguez-Fos, Konstantin Helmsauer, Heathcliff Dorado Garcia, Yi Bei, Karin Schmelz, Sascha Sauer, Angelika Eggert, Johannes H. Schulte, Roland F. Schwarz, Kerstin Haase, Richard P. Koche, Anton G. Henssen
Publikováno v:
Cancer Research. 82:1693-1693
Extrachromosomal DNA circularization is a common event in cancer cells and frequently serves as a vehicle for cancer oncogene amplification. Random segregation of oncogene-containing extrachromosomal circular DNA promotes rapid intercellular heteroge
Autor:
Eric Blanc, Annika Winkler, F Hertwig, Katharina Kasack, Joern Toedling, Filippos Klironomos, Victor Bardinet, Konstantin Helmsauer, Johannes H. Schulte, Anton G. Henssen, Patrick Hundsdörfer, Theresa M Thole, Natalie Timme, Ian C. MacArthur, Richard Koche, David Torrents, Elias Rodriguez-Fos, Nina Thiessen, Claudia Röefzaad, Montserrat Puiggròs, Hedwig E. Deubzer, Jessica Theissen, Karin Schmelz, Dieter Beule, Roland F. Schwarz, Carolina Rosswog, Steffen Fuchs, Rocio Chamorro, Annette Künkele, Angelika Eggert, Heathcliff Dorado Garcia, Sascha Sauer, Martin Burkert, Annabell Szymansky, Jesper L.V. Maag, Natalia Munoz-Perez, Matthias Fischer, Yi Bei
Publikováno v:
Nat Genet
Extrachromosomal circularization of DNA is an important genomic feature in cancer. The structure, composition and genome-wide frequency of extrachromosomal circular DNA, however, have not yet been extensively profiled. Here, we combined genomic and t
Autor:
Kristin Reiche, Katharina Kasack, Stephan Schreiber, Torben Lüders, Eldri U Due, Bjørn Naume, Margit Riis, Vessela N Kristensen, Friedemann Horn, Anne-Lise Børresen-Dale, Jörg Hackermüller, Lars O Baumbusch
Publikováno v:
PLoS ONE, Vol 9, Iss 9, p e106076 (2014)
Breast cancer, the second leading cause of cancer death in women, is a highly heterogeneous disease, characterized by distinct genomic and transcriptomic profiles. Transcriptome analyses prevalently assessed protein-coding genes; however, the majorit
Externí odkaz:
https://doaj.org/article/830aa8163d0f45408734395599e8c03f
Autor:
Nils Blüthgen, Reinhold Schäfer, Thomas Sell, Florian Uhlitz, Bertram Klinger, Matthias Schwab, Johannes Zuber, Mareen Lüthen, Tincy Simon, Sylvia Ispasanie, Natalie Bublitz, Maria Rivera, Nicole Janssen, Bastian Gastl, Pamela Riemer, Kathleen Klotz-Noack, David Horst, Markus Morkel, Katharina Kasack, Christine Sers
Publikováno v:
Cell Reports, Vol 32, Iss 12, Pp 108184-(2020)
Summary: Oncoproteins such as the BRAFV600E kinase endow cancer cells with malignant properties, but they also create unique vulnerabilities. Targeting of BRAFV600E-driven cytoplasmic signaling networks has proved ineffective, as patients regularly r
Autor:
Konstantin Helmsauer, Matthias Fischer, David Torrents, M. E. Valieva, Philipp Euskirchen, F Hertwig, Katharina Kasack, Claudia Röefzaad, Heathcliff Dorado Garcia, Rocío Chamorro González, Luis P. Kuschel, Robert Schöpflin, Kerstin Haase, Stefan Mundlos, Angelika Eggert, Anton G. Henssen, Verena Heinrich, Yi Bei, Johannes Schulte, Richard Koche, Michael I. Robson, Elias Rodriguez-Fos, Montserrat Puiggròs, Carolina Rosswog, Annabell Szymansky, Salaheddine Ali, Jörn Tödling
MYCN amplification drives one in six cases of neuroblastoma. The supernumerary gene copies are commonly found on highly rearranged, extrachromosomal circular DNA. The exact amplicon structure has not been described thus far and the functional relevan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42d9711a48d996498abf07dbc3f6d695
Autor:
Patricia Razquin Navas, Udo Hahn, Kathrin Thedieck, Erik Faessler, Christine Sers, Katharina Kasack, Ahmed Sadik, Christiane A. Opitz, Miriam Langelaar-Makkinje, Philip Marx-Stoelting, Sascha Schäuble, Ines Heiland, Alexander Martin Heberle
Publikováno v:
Life Science Alliance
Life science alliance, 2(2):201800257. Life Science Alliance LLC
Life science alliance, 2(2):201800257. Life Science Alliance LLC
PI3K and p38 act in a hierarchical manner to enhance mTORC1 activity and stress granule formation; although PI3K is the main driver, the impact of p38 gets apparent as PI3K activity declines.
All cells and organisms exhibit stress-coping mechani
All cells and organisms exhibit stress-coping mechani