Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Katharina Iwan"'
Autor:
Franziska R. Traube, Dilara Özdemir, Hanife Sahin, Constanze Scheel, Andrea F. Glück, Anna S. Geserich, Sabine Oganesian, Sarantos Kostidis, Katharina Iwan, René Rahimoff, Grazia Giorgio, Markus Müller, Fabio Spada, Martin Biel, Jürgen Cox, Martin Giera, Stylianos Michalakis, Thomas Carell
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
α-ketoglutarate (αKG) is an intermediate in the tricarboxylic acid cycle that is required in the nucleus for genomic DNA demethylation by Tet3. Here, the authors show that the enzyme glutamate dehydrogenase, which converts glutamate to αKG, is red
Externí odkaz:
https://doaj.org/article/135f870c99dd4995a292de8aef187119
Autor:
Wendy E. Heywood, Katharina Iwan, Kevin Mills, Nina Patel, Sara E. Mole, Philippa B. Mills, Henrik Zetterberg, Amanda Heslegrave, Mina Borisova, Laura Lee, Paul Gissen, Rebecca Bower
Publikováno v:
F1000Research, Vol 10 (2022)
Classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) is caused by a deficiency of tripeptidyl-peptidase-1. In 2017, the first CLN2 enzyme replacement therapy (ERT) cerliponase alfa (Brineura) was approved by the FDA and EMA. The CLN2
Externí odkaz:
https://doaj.org/article/0387b5166bb341ce82bd0f0611c802a9
Autor:
Katharina Iwan, Robert Clayton, Philippa Mills, Barbara Csanyi, Paul Gissen, Sara E. Mole, David N. Palmer, Kevin Mills, Wendy E. Heywood
Publikováno v:
iScience, Vol 24, Iss 2, Pp 102020- (2021)
Summary: The neuronal ceroid lipofuscinoses (NCL) are a group of 13 rare neurodegenerative disorders characterized by accumulation of cellular storage bodies. There are few therapeutic options, and existing tests do not monitor disease progression an
Externí odkaz:
https://doaj.org/article/8968bf7cac6e4338a05dc698aa78468a
Autor:
Amarande Murisier, Marie Andrie, Szabolcs Fekete, Matthew Lauber, Valentina D'Atri, Katharina Iwan, Davy Guillarme
Publikováno v:
Journal of Separation Science. 45
Autor:
Amarande Murisier, Marie Andrie, Szabolcs Fekete, Matthew Lauber, Valentina D'Atri, Katharina Iwan, Davy Guillarme
Publikováno v:
Journal of separation science. 45(12)
The present study describes the possibilities offered by an innovative bioinert size exclusion chromatography column for size variant characterization of complex monoclonal antibody products. This size exclusion chromatography column includes a novel
Autor:
Katharina Iwan, Nina Patel, Amanda Heslegrave, Mina Borisova, Laura Lee, Rebecca Bower, Sara E. Mole, Philippa B. Mills, Henrik Zetterberg, Kevin Mills, Paul Gissen, Wendy E. Heywood
Publikováno v:
F1000Research
Classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) is caused by a deficiency of tripeptidyl-peptidase-1. In 2017, the first CLN2 enzyme replacement therapy (ERT) cerliponase alfa (Brineura) was approved by the FDA and EMA. The CLN2
Autor:
Fabio Spada, Stefanie Kellner, Katharina Iwan, Franziska R. Traube, Markus Müller, Thomas Carell, Sarah Schiffers
Publikováno v:
Nature Protocols. 14:283-312
DNA contains not only canonical nucleotides but also a variety of modifications of the bases. In particular, cytosine and adenine are frequently modified. Determination of the exact quantity of these noncanonical bases can contribute to the character
Autor:
Katharina Iwan, Kevin Mills, Sara E. Mole, Robert Clayton, Paul Gissen, Philippa B. Mills, David Palmer, Wendy E. Heywood, Barbara Csányi
Publikováno v:
iScience
iScience, Vol 24, Iss 2, Pp 102020-(2021)
iScience, Vol 24, Iss 2, Pp 102020-(2021)
Summary The neuronal ceroid lipofuscinoses (NCL) are a group of 13 rare neurodegenerative disorders characterized by accumulation of cellular storage bodies. There are few therapeutic options, and existing tests do not monitor disease progression and
Autor:
Laura Osorio-Planes, Phillip L. Geissler, Michael Groll, Johannes Broichhagen, Katharina Iwan, Dirk Trauner, Kateri H. DuBay
Publikováno v:
ACS Chemical Biology. 13:793-800
Optogenetics and photopharmacology are powerful approaches to investigating biochemical systems. While the former is based on genetically encoded photoreceptors that utilize abundant chromophores, the latter relies on synthetic photoswitches that are
Autor:
Sara E. Mole, Henrik Zetterberg, Katharina Iwan, Laura M. Lee, Nina Patel, Mina Borisova, Paul Gissen, Amanda Heslegrave, Wendy E. Heywood, Philippa B. Mills, Kevin Mills, Rebecca Bower
Publikováno v:
F1000Research. 10:614
Classic late infantile neuronal ceroid lipofuscinosis (CLN2 disease) is caused by a deficiency of tripeptidyl-peptidase-1. In 2017, the first CLN2 enzyme replacement therapy (ERT) cerliponase alfa (Brineura) was approved by the FDA and EMA. The CLN2