Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Katharina I Deeg"'
Publikováno v:
Frontiers in Oncology, Vol 6 (2016)
Telomere maintenance is a hallmark of cancer as it provides cancer cells with cellular immortality. A significant fraction of tumors uses the alternative lengthening of telomeres (ALT) pathway to elongate their telomeres and to gain an unlimited prol
Externí odkaz:
https://doaj.org/article/caee669e6d2c40e0883491506e09ab9f
Publikováno v:
BMC Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
Abstract Background The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telom
Externí odkaz:
https://doaj.org/article/0fea98f1f5b64f77ba74765fe71065c6
Autor:
Karsten Rippe, Benedikt Brors, Peter Lichter, Katharina I. Deeg, David T.W. Jones, Sadaf S. Mughal, Stefan Fröhling, Lina Sieverling, Barbara Hutter, Claudia Scholl, Hanno Glimm, Stefan M. Pfister, Paul A. Northcott, Priya Chudasama, Ivo Buchhalter, Lars Feuerbach, Philip Ginsbach
Publikováno v:
BMC Bioinformatics
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-11 (2019)
Background Establishment of telomere maintenance mechanisms is a universal step in tumor development to achieve replicative immortality. These processes leave molecular footprints in cancer genomes in the form of altered telomere content and aberrati
Autor:
Billy Michael Chelliah Jebaraj, Kristian W. Pajtler, Jennifer Edelmann, Uri Tabori, Marcel Kool, Stephan Stilgenbauer, Aurélie Ernst, Andrey Korshunov, Pedro Castelo-Branco, Katharina I. Deeg, Stefan M. Pfister, Sebastian Bender, Peter Lichter, Marc Zapatka, Kendra K. Maass, David T.W. Jones, Agata Rode, Sebastian Brabetz, Karsten Rippe, Frauke Devens, Michael A. Tainsky, David Malkin, Cindy Zhang, Volker Hovestadt, Susanne Gröbner
Publikováno v:
International Journal of Cancer. 138:2905-2914
Chromothripsis is a recently discovered form of genomic instability, characterized by tens to hundreds of clustered DNA rearrangements resulting from a single dramatic event. Telomere dysfunction has been suggested to play a role in the initiation of
Publikováno v:
BMC Genetics
BMC Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
BMC Genetics, Vol 19, Iss 1, Pp 1-10 (2018)
The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences that are protected by the shelterin protein complex. Cancer cells need to extend these telomere repeats for their unlimited proliferation, either by reactivating the rev
Autor:
Katharina I. Deeg, Stefan Wörz, Karl Rohr, Daniel Parisotto, Sarah Osterwald, Karsten Rippe, Holger Erfle, Inn Chung
Publikováno v:
Journal of Cell Science. 128:1887-1900
The alternative lengthening of telomeres (ALT) mechanism allows cancer cells to escape senescence and apoptosis in the absence of active telomerase. A characteristic feature of this pathway is the assembly of ALT-associated promyelocytic leukemia (PM
Autor:
Stefan Gröschel, Stefan Fröhling, Simon Schimmack, Marcus Renner, Albrecht Stenzinger, Mario Hlevnjak, Christof von Kalle, Christoph E. Heilig, Sebastian Bauer, Inn Chung, Daniel Hübschmann, Katharina I. Deeg, Benedikt Brors, Siao Han Wong, Barbara Hutter, Lina Sieverling, Bernd Kasper, Remco Hoogenboezem, Hanno Glimm, Barbara Klink, Peter Hohenberger, Marc Zapatka, Aurélie Ernst, Alexis Ulrich, Sadaf S. Mughal, Hans-Georg Kopp, Matthias Schlesner, Wilko Weichert, Gunhild Mechtersheimer, Gerlinde Egerer, Kortine Kleinheinz, Stephan E. Wolf, Roland Eils, Georg W. Omlor, Priya Chudasama, Claudia Scholl, Evelin Schröck, Sophie Rabe, Karsten Rippe, Mathijs A. Sanders, Burkhard Lehner
Publikováno v:
Nature Communications
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications, 9:144. Nature Publishing Group
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Nature Communications, 9:144. Nature Publishing Group
Leiomyosarcoma (LMS) is an aggressive mesenchymal malignancy with few therapeutic options. The mechanisms underlying LMS development, including clinically actionable genetic vulnerabilities, are largely unknown. Here we show, using whole-exome and tr
Autor:
Rainer König, Katharina I. Deeg, Andrey Korshunov, Stefan M. Pfister, Inn Chung, David T.W. Jones, Karsten Rippe, David Castel, Sebastian Bender, Marcus Oswald, Nick Kepper, Jacques Grill, Alexandra M Poos, Peter Lichter, Delia M. Braun
Pediatric glioblastoma (pedGBM) represent a highly malignant primary brain tumor with recurrent mutations in the chromatin remodeler ATRX and the histone variant H3.3 that is typically associated with a fatal outcome. ATRX acts as suppressor of the a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96cdd1691515ab250c58213564fe26d1
https://doi.org/10.1101/129106
https://doi.org/10.1101/129106
Autor:
Ivo Buchhalter, Lars Feuerbach, Philip Ginsbach, Karsten Rippe, Barbara Hutter, Peter Lichter, Benedikt Brors, David T.W. Jones, Paul A. Northcott, Lina Sieverling, Stefan M. Pfister, Katharina I. Deeg
Summary:Telomere shortening plays an important role in cellular aging and tumor suppression. The availability of large next-generation sequencing cohorts of matched tumor and control samples enables a computational high-throughput analysis of changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a1059886eba43214f441d5d36680d48
https://doi.org/10.1101/065532
https://doi.org/10.1101/065532
Autor:
Manuel Gunkel, Katharina I. Deeg, Ronald Simon, David T.W. Jones, Holger Erfle, Karl Rohr, Guido Sauter, Karsten Rippe, Stefan Wörz, Andrey Korshunov, Inn Chung
Publikováno v:
Methods (San Diego, Calif.). 114
The microscopic analysis of telomere features provides a wealth of information on the mechanism by which tumor cells maintain their unlimited proliferative potential. Accordingly, the analysis of telomeres in tissue sections of patient tumor samples