Výsledky vyhledávání - "Katharina Helen Surinya"

Characterization of insulin/IGF hybrid receptors: contributions of the insulin receptor L2 and Fn1 domains and the alternatively spliced exon 11 sequence to ligand binding and receptor activation

Autor: Kenneth Siddle, Dirk Hadaschik, Katharina Helen Surinya, Samira Benyoucef

Publikováno v: Biochemical Journal. 403:603-613

The IR (insulin receptor) and IGFR (type I insulin-like growth factor receptor) are found as homodimers, but the respective pro-receptors can also heterodimerize to form insulin–IGF hybrid receptors. There are conflicting data on the ligand affinit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d15595750f560329547935bfcfc9c16d
https://doi.org/10.1042/bj20061709

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Role of insulin receptor dimerization domains in ligand binding, cooperativity, and modulation by anti-receptor antibodies

Autor: Maria A. Soos, Kenneth Siddle, Katharina Helen Surinya, Jakob Brandt, Laurence Molina, Claus Kristensen

Publikováno v: The Journal of biological chemistry. 277(19)

To define the structures within the insulin receptor (IR) that are required for high affinity ligand binding, we have used IR fragments consisting of four amino-terminal domains (L1, cysteine-rich, L2, first fibronectin type III domain) fused to sequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78537fdf0bef50d8384f0f21a4cde941
https://pubmed.ncbi.nlm.nih.gov/11875066

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Specificity in ligand binding and intracellular signalling by insulin and IGF receptors

Autor: C. A. Niesler, Katharina Helen Surinya, Birgitte Ursø, Maria A. Soos, L. Molina, Diane L. Cope, K. Siddle

Publikováno v: Biochemical Society Transactions. 29:A57-A57

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::840c0c27bcc708c4688385e55df64740
https://doi.org/10.1042/bst029a057b

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