Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Katharina Flach"'
Autor:
Lydia Herrmann, Caspar Wiegmann, Annika Arsalan-Werner, Isabel Hilbrich, Carsten Jäger, Katharina Flach, Anne Suttkus, Ingolf Lachmann, Thomas Arendt, Max Holzer
Publikováno v:
PLoS ONE, Vol 10, Iss 3, p e0119423 (2015)
Defects in intracellular transport are implicated in the pathogenesis of Alzheimer's disease (AD). Hook proteins are a family of cytoplasmic linker proteins that participate in endosomal transport. In this study we show that Hook1 and Hook3 are expre
Externí odkaz:
https://doaj.org/article/3eecbc427092408e831b63c51935cfc7
Autor:
Juan Manuel Maler, Johannes Kornhuber, Sebastiaan Engelborghs, Barbara Mroczko, Philipp Spitzer, Lucilla Parnetti, Charlotte E. Teunissen, Sebastian Brandner, Max Holzer, Natalia Lelental, Armand Perret-Liaudet, Davide Chiasserini, Piotr Lewczuk, Henrik Zetterberg, José Luis Molinuevo, Ingolf Lachmann, Julius Popp, Kaj Blennow, Katharina Flach
Publikováno v:
Journal of Alzheimer's Disease, Vol. 55, No 1 (2017) pp. 159-170
Journal of Alzheimer's Disease
Journal of Alzheimer's disease
Journal of Alzheimer's Disease
Journal of Alzheimer's disease
Background: Virtually nothing is known about a potential diagnostic role of non-phospho-epitopes of Tau (Non-P-Tau) in cerebrospinal fluid (CSF). Objective: To establish and analytically and clinically characterize the first assay capable to measure
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7bea197dd84f75b93e7d8659fb53c95f
https://archive-ouverte.unige.ch/unige:105992
https://archive-ouverte.unige.ch/unige:105992
Autor:
Hanka Waschipky, Thomas Arendt, Marion Leonhardt, Andrea Schiffmann, Max Holzer, Katharina Flach, Martin Krüger, Lukas Y. Wick, Ulrich Gärtner, Isabel Hilbrich
Publikováno v:
Journal of Biological Chemistry. 287:43223-43233
The microtubule-associated protein Tau is mainly expressed in neurons, where it binds and stabilizes microtubules. In Alzheimer disease and other tauopathies, Tau protein has a reduced affinity toward microtubules. As a consequence, Tau protein detac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17bd667506bd67e4049e2f6ffd8275d
https://doi.org/10.1074/jbc.m112.396176
https://doi.org/10.1074/jbc.m112.396176
Autor:
Till Voigtländer, Uta Wagner, Aline Geneste, Armand Perret-Liaudet, Gabor G. Kovacs, Katharina Flach, Walter Pirker, Anna S. Berghoff, Ingolf Lachmann, Ursula Unterberger
Publikováno v:
Clinical Neuropathology
With the aim to evaluate the significance and reliability of detecting disease-specific α-synuclein in the cerebrospinal fluid (CSF) we developed an ELISA and bead-assay. We used a commercial antibody (5G4) that does not bind to the physiological mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac8a3808cacf90914edba8684d580ef7
https://pubmed.ncbi.nlm.nih.gov/25131945
https://pubmed.ncbi.nlm.nih.gov/25131945
Autor:
Max Holzer, Galina Dityateva, Melitta Schachner, Alexander Dityatev, Markus Morawski, Jens Grosche, Gert Brückner, Sanja Pavlica, Maren Blosa, Katharina Flach, Maike Hartlage-Rübsamen
Publikováno v:
Philosophical transactions / B 369(1654), 20140046 (2014). doi:10.1098/rstb.2014.0046
Perineuronal nets (PNs) in the brains of tenascin-R-deficient ( tn-r −/− ) mice develop in temporal concordance with those of wild-type ( tn-r +/+ ) mice. However, the histological appearance of PNs is abnormal in adult tn-r −/− mice. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c18ae38ea6ce3dbeca7aae52fa9c902
https://pub.dzne.de/record/137560
https://pub.dzne.de/record/137560
Publikováno v:
BMC Neuroscience, Vol 8, Iss Suppl 1, p P15 (2007)
Axotrophin harbours a C4HC3 zinc-finger-like motif in the C-terminus, which is referred to as Ring-variant domain and has been implicated in protein ubiquitination. Recombinant expression and refolding of the C-terminus of axotrophin allowed us to te
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c6008c6401d353811f706a233500c1b
https://doi.org/10.1186/1471-2202-8-s1-p15
https://doi.org/10.1186/1471-2202-8-s1-p15
Publikováno v:
Journal of Biological Chemistry 282(2007)10, 6984-6991
Accumulation of hyperphosphorylated Tau protein as paired helical filaments in pyramidal neurons is a major hallmark of Alzheimer disease. Besides hyperphosphorylation, other modifications of the Tau protein, such as cross-linking, are likely to cont
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b974abe71317093120101ee807ecfe10
https://pubmed.ncbi.nlm.nih.gov/17082178
https://pubmed.ncbi.nlm.nih.gov/17082178
Autor:
Lydia Herrmann, Thomas Arendt, Max Holzer, Michel Goedert, Isabel Hilbrich, Katharina Flach, Franziska Albrecht, Annika Arsalan-Werner, Ellen Ramminger
Publikováno v:
Biochimica et Biophysica Acta
Tau is the major microtubule-associated protein in neurons involved in microtubule stabilization in the axonal compartment. Changes in tau gene expression, alternative splicing and posttranslational modification regulate tau function and in tauopathi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19da8df0d6d4f5bd35295a43ed7d50e2