DNA methylation-based classification and grading system for meningioma: a multicentre, retrospective analysis

Autor: Marcel Seiz-Rosenhagen, Daniel Hänggi, Thomas Hielscher, Ralf Ketter, Jens Schittenhelm, Dominik Sturm, Manfred Westphal, Andreas Unterberg, Christel Herold-Mende, Michel Mittelbronn, Michael Weller, Stefan M. Pfister, Stefanie Brehmer, Peter Baumgarten, Martin Sill, Christian Koelsche, David T.W. Jones, Christian Mawrin, Matthias Simon, Lukas Chavez, Annekathrin Kratz, Anna S. Berghoff, Hans-Georg Wirsching, Sebastian Schefzyk, Matthias Schick, Annika K. Wefers, V. Peter Collins, Hayley P Ellis, Andreas von Deimling, Albert J. Becker, Kathreena M Kurian, Matthias Preusser, Damian Stichel, Felix Sahm, Michael Platten, Katharina Drueschler, Werner Paulus, Arend Koch, Ali Fuat Okuducu, Melanie Bewerunge-Hudler, Volker Hovestadt, Katrin Lamszus, Elisabeth J. Rushing, Kristin Huang, David Capper, Wolfgang Wick, David E. Reuss, Daniel Schrimpf, Christine Jungk, Konstantin Okonechnikov

Publikováno v: Sahm, F, Schrimpf, D, Stichel, D, Jones, D T W, Hielscher, T, Schefzyk, S, Okonechnikov, K, Koelsche, C, Reuss, D E, Capper, D, Sturm, D, Wirsching, H-G, Berghoff, A S, Baumgarten, P, Kratz, A, Huang, K, Wefers, A K, Hovestadt, V, Sill, M, Ellis, H P, Kurian, K M, Okuducu, A F, Jungk, C, Drueschler, K, Schick, M, Bewerunge-Hudler, M, Mawrin, C, Seiz-Rosenhagen, M, Ketter, R, Simon, M, Westphal, M, Lamszus, K, Becker, A, Koch, A, Schittenhelm, J, Rushing, E J, Collins, V P, Brehmer, S, Chavez, L, Platten, M, Hänggi, D, Unterberg, A, Paulus, W, Wick, W, Pfister, S M, Mittelbronn, M, Preusser, M, Herold-Mende, C, Weller, M & von Deimling, A 2017, ' DNA methylation-based classification and grading system for meningioma : a multicentre, retrospective analysis ', Lancet Oncology, vol. 18, no. 5, pp. 682-694 . https://doi.org/10.1016/S1470-2045(17)30155-9

Summary Background The WHO classification of brain tumours describes 15 subtypes of meningioma. Nine of these subtypes are allotted to WHO grade I, and three each to grade II and grade III. Grading is based solely on histology, with an absence of mol

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https://doi.org/10.1016/s1470-2045(17)30155-9