HIF1α Modulates Cell Fate Reprogramming Through Early Glycolytic Shift and Upregulation of PDK1–3 and PKM2

Autor: Raul Bukowiecki, James Adjaye, Sheila Hoffmann, Thorsten Cramer, Barbara Mlody, Erich E. Wanker, Markus Ralser, Alessandro Prigione, Katharina Drews, Nadine Rohwer, Katharina Blümlein

Publikováno v: Stem Cells. 32:364-376

Reprogramming somatic cells to a pluripotent state drastically reconfigures the cellular anabolic requirements, thus potentially inducing cancer-like metabolic transformation. Accordingly, we and others previously showed that somatic mitochondria and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e07824eded9d5cf7159c3f564e016165
https://doi.org/10.1002/stem.1552

Molecular Signature of Human amniotic Fluid Stem Cells During Fetal Development

Autor: Paolo De Coppi, Dafni Moschidou, Katharina Drews, James Adjaye, Pascale V. Guillot, Ayad Eddaoudi

Publikováno v: Current Stem Cell Research & Therapy. 8:73-81

Mid-gestation c-KIT + amniotic fluid stem cells (AFSC) have an intermediate phenotype between embryonic and adult stem cells and are easy to reprogram to pluripotency. We previously showed that 1 st trimester AFSC can be reprogrammed to functional pl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::959b8a98b37f4f2afa2596c71285c6f4
https://doi.org/10.2174/1574888x11308010009

The cytotoxic and immunogenic hurdles associated with non-viral mRNA-mediated reprogramming of human fibroblasts

Autor: Joanna Rejman, Stefaan C. De Smedt, Joseph Demeester, Katharina Drews, Geertrui Tavernier, Hans Lehrach, James Adjaye

Publikováno v: Biomaterials

Delivery of reprogramming factor-encoding mRNAs by means of lipofection in somatic cells is a desirable method for deriving integration-free iPSCs. However, the lack of reproducibility implies there are major hurdles to overcome before this protocol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0626aae8443998ecdba2b239cac23521
https://doi.org/10.1016/j.biomaterials.2012.02.025

Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes

Autor: Justyna Jozefczuk, Samrina Rehman, Christian R. A. Regenbrecht, Christoph Wierling, Wasco Wruck, Hans V. Westerhoff, Paola Turano, Ewa Gralka, Andriani Daskalaki, Kurt Zatloukal, Katharina Drews, Vikash Pandey, Hans Lehrach, Daniela Berg, Karl Kashofer, James Adjaye, Ulrike Korf

Publikováno v: Scientific Data
Wruck, W, Kashofer, K, Rehman, S, Daskalaki, A, Berg, D, Gralka, E, Jozefczuk, J, Drews, K, Pandey, V, Regenbrecht, C, Wierling, C, Turano, P, Korf, U, Zatloukal, K, Lehrach, H, Westerhoff, H V & Adjaye, J 2015, ' Multi-omic profiles of human non-alcoholic fatty liver disease tissue highlight heterogenic phenotypes. ', Scientific Data, vol. 2, 150068 . https://doi.org/10.1038/sdata.2015.68
Scientific Data, 2:150068. Nature Publishing Group

Non-alcoholic fatty liver disease (NAFLD) is a consequence of sedentary life style and high fat diets with an estimated prevalence of about 30% in western countries. It is associated with insulin resistance, obesity, glucose intolerance and drug toxi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cccd66a930ba17d8d02af9748e2157
https://hdl.handle.net/11858/00-001M-0000-002D-434E-311858/00-001M-0000-002D-434C-7

Human induced pluripotent stem cells--from mechanisms to clinical applications

Autor: James Adjaye, Justyna Jozefczuk, Alessandro Prigione, Katharina Drews

Publikováno v: Journal of Molecular Medicine-JMM

Human pluripotent stem cells hold great promise for basic research and regenerative medicine due to their inherent property to propagate infinitely, while maintaining the potential to differentiate into any given cell type of the human body. Since th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40c156905e782f1c22fd6263c878c4c7
https://pubmed.ncbi.nlm.nih.gov/22643868