Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Katharina Belz"'
Publikováno v:
Cell Death & Differentiation. 22:1946-1956
Polo-like kinase 1 (PLK1) is frequently overexpressed in cancer, which correlates with poor prognosis. Therefore, we investigated PLK1 as therapeutic target using rhabdomyosarcoma (RMS) as a model. Here, we identify a novel synthetic lethal interacti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f00fbb0d8cc2437a24e0dceef33e48e9
https://doi.org/10.1038/cdd.2015.59
https://doi.org/10.1038/cdd.2015.59
Publikováno v:
Oncogene. 34:4032-4043
Evasion of apoptosis in pediatric acute lymphoblastic leukemia (ALL) is linked to aberrant expression of inhibitor of apoptosis (IAP) proteins and dysregulated redox homeostasis, rendering leukemic cells vulnerable to redox-targeting therapies. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93a00aef284fd5e6ad98c61c4873d66a
https://doi.org/10.1038/onc.2014.338
https://doi.org/10.1038/onc.2014.338
Publikováno v:
Cancer letters. 355(2)
Therapeutic targeting of inhibitor of apoptosis (IAP) proteins by small-molecule inhibitors such as Smac mimetic is considered as a promising anticancer strategy to elicit apoptosis. Recent advances have renewed the interest in exploiting the antileu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b88adce6fd4ee0624ec7e9890dfc3bbc
https://pubmed.ncbi.nlm.nih.gov/25179908
https://pubmed.ncbi.nlm.nih.gov/25179908
Autor:
S. Wehner, Thomas Klingebiel, Halvard Bonig, Hannah Schoeneberger, Simone Fulda, Katharina Belz, Andreas Weigert, Iduna Fichtner
Publikováno v:
Blood. 124(2)
Apoptosis resistance contributes to poor outcome in pediatric acute lymphoblastic leukemia (ALL). Here, we identify a novel synergistic combination of Smac mimetic BV6 and glucocorticoids (GCs) (ie, dexamethasone, prednisolone) to trigger apoptosis i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58fd3576140e59bbd92b12652ab3e74f
https://pubmed.ncbi.nlm.nih.gov/24855207
https://pubmed.ncbi.nlm.nih.gov/24855207
Publikováno v:
Cell Death & Disease
Evasion of apoptosis, for example, by inhibitor of apoptosis (IAP) proteins, contributes to treatment resistance and poor outcome in acute myeloid leukemia (AML). Here we identify a novel synergistic interaction between the small-molecule second mito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::347d2e22f5961ca79ea25e501a47f8d7
https://doi.org/10.1038/cddis.2013.320
https://doi.org/10.1038/cddis.2013.320