A unique profilin-actin interface is important for malaria parasite motility.

Autor: Catherine A Moreau, Saligram P Bhargav, Hirdesh Kumar, Katharina A Quadt, Henni Piirainen, Léanne Strauss, Jessica Kehrer, Martin Streichfuss, Joachim P Spatz, Rebecca C Wade, Inari Kursula, Friedrich Frischknecht

Publikováno v: PLoS Pathogens, Vol 13, Iss 5, p e1006412 (2017)

Profilin is an actin monomer binding protein that provides ATP-actin for incorporation into actin filaments. In contrast to higher eukaryotic cells with their large filamentous actin structures, apicomplexan parasites typically contain only short and

Externí odkaz: https://doaj.org/article/39be23259baa48b2af725aa8551bff17

A function of profilin in force generation during malaria parasite motility that is independent of actin binding

Autor: Rebecca C. Wade, Henni Piirainen, Léanne Strauss, Catherine A Moreau, Hirdesh Kumar, Joachim P. Spatz, Friedrich Frischknecht, Inari Kursula, Saligram Prabhakar Bhargav, Niraj H. Tolia, Katharina A. Quadt

Publikováno v: jcs233775
Journal of Cell Science

During transmission of malaria-causing parasites from mosquito to mammal, Plasmodium sporozoites migrate at high speed within the skin to access the bloodstream and infect the liver. This unusual gliding motility is based on retrograde flow of membra

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42119cf53fc5857feb02be8744bca06d
https://hdl.handle.net/11250/2739443

The sickle cell trait affects contact dynamics and endothelial cell activation in Plasmodium falciparum-infected erythrocytes

Autor: Dimitris Missirlis, Christine Lansche, Marilou Tétard, Anil K. Dasanna, Benjamin Fröhlich, Benoit Gamain, Ulrich S. Schwarz, Cecilia P. Sanchez, Katharina A. Quadt, Bernd Buchholz, Motomu Tanaka, Michael Lanzer

Publikováno v: Communications Biology, Vol 1, Iss 1, Pp 1-14 (2018)
Communications Biology
Communications Biology, Nature Publishing Group, 2018, 1 (1), ⟨10.1038/s42003-018-0223-3⟩

Sickle cell trait, a common hereditary blood disorder, protects carriers from severe disease in infections with the human malaria parasite Plasmodium falciparum. Protection is associated with a reduced capacity of parasitized erythrocytes to cytoadhe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ae7fdc3d5b32dd1b138b7b292d2de34
http://link.springer.com/article/10.1038/s42003-018-0223-3

Coupling of retrograde flow to force production during malaria parasite migration

Autor: Katharina A. Quadt, Catherine A Moreau, Martin Streichfuss, Friedrich Frischknecht, Joachim P. Spatz

Publikováno v: ACS Nano

Migration of malaria parasites is powered by a myosin motor that moves actin filaments, which in turn link to adhesive proteins spanning the plasma membrane. The retrograde flow of these adhesins appears to be coupled to forward locomotion. However,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54e03588008da99a536f0080b5c6453d
https://hdl.handle.net/11858/00-001M-0000-002C-88C1-111858/00-001M-0000-002B-1C11-7

Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed

Autor: Lars Hviid, Jens E.V. Petersen, Anine Jeppesen, Casper Hempel, Lea Barfod, Katharina A. Quadt, Tue Hassenkam, Ramesh Subramani

Publikováno v: Subramani, R, Quadt, K, Jeppesen, A E, Hempel, C, Petersen, J E V, Hassenkam, T, Hviid, L & Barfod, L K 2015, ' Plasmodium falciparum-infected erythrocyte knob density is linked to the PfEMP1 variant expressed ', mBio, vol. 6, no. 5, e01456-15 . https://doi.org/10.1128/mBio.01456-15
mBio, Vol 6, Iss 5 (2015)
mBio

Members of the clonally variant Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) family mediate adhesion of infected erythrocytes (IEs) to vascular receptors. PfEMP1 expression is normally confined to nanoscale knob protrusions on the IE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7084c0989e0f17f17e09373b385f7938
https://curis.ku.dk/portal/da/publications/plasmodium-falciparuminfected-erythrocyte-knob-density-is-linked-to-the-pfemp1-variant-expressed(8cfe3423-0c32-428d-8c7f-f34f1ff6ba0a).html