Výsledky vyhledávání - "Katharina Arenz"

Development of New Cathepsin B Inhibitors: Combining Bioisosteric Replacements and Structure-Based Design To Explore the Structure–Activity Relationships of Nitroxoline Derivatives

Autor: Bogdan Štefane, Stanislav Gobec, Izidor Sosič, Janko Kos, Katharina Arenz, Bojana Mirković

Publikováno v: Journal of Medicinal Chemistry. 56:521-533

Human cathepsin B has many house-keeping functions, such as protein turnover in lysosomes. However, dysregulation of its activity is associated with numerous diseases, including cancers. We present here the structure-based design and synthesis of new

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e200bb812c43e744c02a0ca84470ce
https://doi.org/10.1021/jm301544x

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Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface

Autor: Stefan Frank, Angelika Horstmeyer, Kai Prager, Tobias Bald, Eva Maurer, Jochen Walter, Sonja Kolp, Patrick Wunderlich, Michael Gütschow, Andreas Janzer, Marit Stirnberg, Katharina Arenz

Publikováno v: Biochemical Journal. 430:87-95

Matriptase-2 is a member of the TTSPs (type II transmembrane serine proteases), an emerging class of cell surface proteases involved in tissue homoeostasis and several human disorders. Matriptase-2 exhibits a domain organization similar to other TTSP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::395383bf500aaa4c17efa04daa75bdc0
https://doi.org/10.1042/bj20091565

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Cell surface serine protease matriptase-2 suppresses fetuin-A/AHSG-mediated induction of hepcidin

Autor: Marit Stirnberg, Willi Jahnen-Dechent, Michael Gütschow, Katharina Arenz, Anne Babler, Eva Maurer

Publikováno v: Biological chemistry. 396(1)

Matriptase-2 is a type II transmembrane serine protease controlling the expression of hepcidin, the key regulator of iron homeostasis. By cleaving hemojuvelin, matriptase-2 suppresses bone morphogenetic protein/sons of mothers against decapentaplegic

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9ab9dbf1d646d98b03b0176c42e9fee
https://pubmed.ncbi.nlm.nih.gov/25205713

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Akademický článek

Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface.

Autor: Marit Stirnberg, Eva Maurer, Angelika Horstmeyer, Sonja Kolp, Stefan Frank, Tobias Bald, Katharina Arenz, Andreas Janzer, Kai Prager, Patrick Wunderlich, Jochen Walter, Michael Gütschow

Publikováno v: Biochemical Journal; Jul2010, Vol. 430 Issue 1, p87-95, 9p

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