Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Katharina, Stadlbauer"'
Autor:
Aleksandra Rodak, Katharina Stadlbauer, Madhusudhan Reddy Bobbili, Oskar Smrzka, Florian Rüker, Gordana Wozniak Knopp
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 19, p 14997 (2023)
High numbers of membrane immunoglobulin E (IgE)-positive cells are characteristic of allergic conditions, atopic dermatitis, or IgE myeloma. Antibodies targeting the extracellular membrane-proximal domain of the membranous IgE-B-cell receptor (BCR) f
Externí odkaz:
https://doaj.org/article/1c4404d2337844d191c89fffa098e661
Autor:
Stefan Vogt, Madhusudhan Reddy Bobbili, Gerhard Stadlmayr, Katharina Stadlbauer, Jørgen Kjems, Florian Rüker, Johannes Grillari, Gordana Wozniak‐Knopp
Publikováno v:
Journal of Extracellular Vesicles, Vol 10, Iss 11, Pp n/a-n/a (2021)
Abstract The research of extracellular vesicles (EVs) has boomed in the last decade, with the promise of them functioning as target‐directed drug delivery vehicles, able to modulate proliferation, migration, differentiation, and other properties of
Externí odkaz:
https://doaj.org/article/6bb7e1c4aa194071801a85a4ec26f2e8
Autor:
Filippo Benedetti, Florian Stracke, Gerhard Stadlmayr, Katharina Stadlbauer, Florian Rüker, Gordana Wozniak-Knopp
Publikováno v:
Biochemistry and Biophysics Reports, Vol 26, Iss , Pp 100959- (2021)
Monoclonal antibodies can acquire the property of engagement of a second antigen via fusion methods or modification of their CDR loops, but also by modification of their constant domains, such as in the mAb2 format where a set of mutated amino acid r
Externí odkaz:
https://doaj.org/article/c43f517524754880b430364cfea6437b
Autor:
Katharina Stadlbauer, Peter Andorfer, Gerhard Stadlmayr, Florian Rüker, Gordana Wozniak-Knopp
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5208 (2022)
Inhibition of complement activation via the overexpression of complement-regulatory proteins (CRPs), most notably CD46, CD55 and CD59, is an efficient mechanism of disguise of cancer cells from a host immune system. This phenomenon extends to counter
Externí odkaz:
https://doaj.org/article/1a3f0a9a09d44abb8dec2c63f7204481
Autor:
Aleksandra Rodak, Gerhard Stadlmayr, Katharina Stadlbauer, Dominic Lichtscheidl, Madhusudhan Reddy Bobbili, Florian Rüker, Gordana Wozniak-Knopp
Publikováno v:
Biomedicines, Vol 9, Iss 11, p 1568 (2021)
The increased incidence of allergies and asthma has sparked interest in IgE, the central player in the allergic response. Interaction with its high-affinity receptor FcεRI leads to sensitization and allergen presentation, extracellular membrane-prox
Externí odkaz:
https://doaj.org/article/d5a2f8f936e9455eb7b76ffab63946c1
Autor:
Filippo Benedetti, Katharina Stadlbauer, Gerhard Stadlmayr, Florian Rüker, Gordana Wozniak-Knopp
Publikováno v:
Life, Vol 11, Iss 11, p 1157 (2021)
The overexpression of tyrosine kinase HER2 in numerous cancers, connected with fierce signaling and uncontrolled proliferation, makes it a suitable target for immunotherapy. The acquisition of resistance to currently used compounds and the multiplici
Externí odkaz:
https://doaj.org/article/f42e6e0c6abc414a8056859947759502
Autor:
Veronica Natale, Gerhard Stadlmayr, Filippo Benedetti, Katharina Stadlbauer, Florian Rüker, Gordana Wozniak-Knopp
Publikováno v:
Biological Chemistry. 403:509-523
Bispecific antibodies and antibody fragments are therapeutics of growing importance. They are clinically applied for effector cell engagement, enhanced targeting selectivity, addressing of multiple cellular pathways and active transfer of certain act
Autor:
Gordana Wozniak-Knopp, Gerhard Stadlmayr, Jan Walther Perthold, Katharina Stadlbauer, Mathias Gotsmy, Stefan Becker, Florian Rüker
Publikováno v:
PLoS ONE, Vol 13, Iss 4, p e0195442 (2018)
We have designed a complete antibody-like construct where the CH1 and Cκ domains are exchanged for a pair of the CH3 domains and efficient pairing of the heavy and light variable domain is achieved using "Knobs-into-Holes" strategy. This construct,
Externí odkaz:
https://doaj.org/article/6fd29778184a4a0396484ba2c6136214
Publikováno v:
BIOspektrum. 27:495-499
Nearly seventy years have passed since the first attempts to fuse the antibodies, „magic bullets“ with exquisite target specificity, into multispecific agents that can connect a targeted cell with an effector immune cell. Such efforts have trigge
Autor:
Stefan, Vogt, Gerhard, Stadlmayr, Katharina, Stadlbauer, Florian, Stracke, Madhusudhan Reddy, Bobbili, Johannes, Grillari, Florian, Rüker, Gordana, Wozniak-Knopp
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 2491
Over the last two decades, yeast display methodology has served as a popular tool for discovery, humanization, stability improvement, and affinity maturation of antibodies and antibody fragments, but also for development of diverse non-antibody prote