Zobrazeno 1 - 10
of 116
pro vyhledávání: '"Katharina, Nöh"'
Autor:
Johannes Seiffarth, Tim Scherr, Bastian Wollenhaupt, Oliver Neumann, Hanno Scharr, Dietrich Kohlheyer, Ralf Mikut, Katharina Nöh
Publikováno v:
SoftwareX, Vol 26, Iss , Pp 101638- (2024)
Automated microscopy techniques combined with high-throughput microfluidic cultivation systems provide unique insights into living microorganisms, enabling hundreds of experiments to be performed in parallel. Such setups generate large data sets with
Externí odkaz:
https://doaj.org/article/940a48668008476a86e40db4a5f2dfd8
Autor:
Susana Matamouros, Thomas Gensch, Martin Cerff, Christian C. Sachs, Iman Abdollahzadeh, Johnny Hendriks, Lucas Horst, Niklas Tenhaef, Julia Tenhaef, Stephan Noack, Michaela Graf, Ralf Takors, Katharina Nöh, Michael Bott
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract Bacterial growth rate (µ) depends on the protein synthesis capacity of the cell and thus on the number of active ribosomes and their translation elongation rate. The relationship between these fundamental growth parameters have only been de
Externí odkaz:
https://doaj.org/article/d800cd80ff224159a7ef89ec11071962
Autor:
Khushboo Borah Slater, Martin Beyß, Ye Xu, Jim Barber, Catia Costa, Jane Newcombe, Axel Theorell, Melanie J Bailey, Dany J V Beste, Johnjoe McFadden, Katharina Nöh
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 3, Pp 1-18 (2023)
Abstract Metabolic flux is the final output of cellular regulation and has been extensively studied for carbon but much less is known about nitrogen, which is another important building block for living organisms. For the tuberculosis pathogen, this
Externí odkaz:
https://doaj.org/article/5bb60f4298fe4261b1609c783aff848a
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011378 (2023)
Thinning is a sub-sampling technique to reduce the memory footprint of Markov chain Monte Carlo. Despite being commonly used, thinning is rarely considered efficient. For sampling constraint-based models, a highly relevant use-case in systems biology
Externí odkaz:
https://doaj.org/article/3fdf892c6c6f4cf187112b27c677d71b
Autor:
Karin Mitosch, Martin Beyß, Prasad Phapale, Bernhard Drotleff, Katharina Nöh, Theodore Alexandrov, Kiran R Patil, Athanasios Typas
Publikováno v:
PLoS Biology, Vol 21, Iss 8, p e3002198 (2023)
Pathogenic bacteria proliferating inside mammalian host cells need to rapidly adapt to the intracellular environment. How they achieve this and scavenge essential nutrients from the host has been an open question due to the difficulties in distinguis
Externí odkaz:
https://doaj.org/article/eb9d89e1b0b643e18e61f852a3fec525
Autor:
Keitaro Kasahara, Markus Leygeber, Johannes Seiffarth, Karina Ruzaeva, Thomas Drepper, Katharina Nöh, Dietrich Kohlheyer
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
Microfluidic cultivation devices that facilitate O2 control enable unique studies of the complex interplay between environmental O2 availability and microbial physiology at the single-cell level. Therefore, microbial single-cell analysis based on tim
Externí odkaz:
https://doaj.org/article/9c5c539f2c7740ca9aef669f6997ecd7
Autor:
Tim Scherr, Johannes Seiffarth, Bastian Wollenhaupt, Oliver Neumann, Marcel P Schilling, Dietrich Kohlheyer, Hanno Scharr, Katharina Nöh, Ralf Mikut
Publikováno v:
PLoS ONE, Vol 17, Iss 11, p e0277601 (2022)
In biotechnology, cell growth is one of the most important properties for the characterization and optimization of microbial cultures. Novel live-cell imaging methods are leading to an ever better understanding of cell cultures and their development.
Externí odkaz:
https://doaj.org/article/f6279da0196f4b62b3bba708d46e2bfe
Autor:
Martina Feierabend, Alina Renz, Elisabeth Zelle, Katharina Nöh, Wolfgang Wiechert, Andreas Dräger
Publikováno v:
Frontiers in Microbiology, Vol 12 (2021)
Corynebacterium glutamicum belongs to the microbes of enormous biotechnological relevance. In particular, its strain ATCC 13032 is a widely used producer of L-amino acids at an industrial scale. Its apparent robustness also turns it into a favorable
Externí odkaz:
https://doaj.org/article/eb879d8e7d04495f956f54a1887fdcd2
Autor:
Christian Carsten Sachs, Joachim Koepff, Wolfgang Wiechert, Alexander Grünberger, Katharina Nöh
Publikováno v:
BMC Bioinformatics, Vol 20, Iss 1, Pp 1-7 (2019)
Abstract Background Streptomycetes are filamentous microorganisms of high biotechnological relevance, especially for the production of antibiotics. In submerged cultures, the productivity of these microorganisms is closely linked to their growth morp
Externí odkaz:
https://doaj.org/article/3b44ed6e4ba04f929f9938d908a0f254
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 9 (2021)
13C metabolic flux analysis (MFA) has become an indispensable tool to measure metabolic reaction rates (fluxes) in living organisms, having an increasingly diverse range of applications. Here, the choice of the13C labeled tracer composition makes the
Externí odkaz:
https://doaj.org/article/c6e9764a4098473db77f892e775ea77a