Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Katharina, Mertsch"'
Publikováno v:
Molecular Pharmaceutics. 15:3425-3433
Cimetidine decreases the renal clearance of metformin by inhibition of renal tubular cation transport, and the underlying molecular mechanisms are still not fully understood. We investigated polarized metformin transport without and with the addition
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41db017ed3e34d96fd1568cda518fd13
https://doi.org/10.1021/acs.molpharmaceut.8b00416
https://doi.org/10.1021/acs.molpharmaceut.8b00416
Autor:
Petra Arndt, Thomas Maier, John Weston, Nils Rackelmann, Katharina Mertsch, Heinrich Christian Englert, Hans Matter, Winfried Heyse, Markus Follmann, Klaus Wirth, Laurent Bialy
Publikováno v:
Journal of Medicinal Chemistry. 59:8812-8829
The design, synthesis, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na+/H+ exchanger type 3 (NHE3) are described based on a hit from high-throughput screening (HTS). The chemical optimization resulted in the di
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1b71b68b14e8ff85d15f311b1a3b4d0d
https://doi.org/10.1021/acs.jmedchem.6b00624
https://doi.org/10.1021/acs.jmedchem.6b00624
Autor:
Martin Sandvoss, Dietmar Weitz, Katharina Mertsch, Martin F. Fromm, Jörg König, Fabian Müller, Volker Derdau
Publikováno v:
Molecular pharmaceutics. 14(9)
The weak base memantine is actively secreted into urine, however the underlying mechanisms are insufficiently understood. Potential candidates involved in memantine renal secretion are organic cation transporter 2 (OCT2) and multidrug and toxin extru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d961844e56e6565b9aa8163b83adcd64
https://pubmed.ncbi.nlm.nih.gov/28708400
https://pubmed.ncbi.nlm.nih.gov/28708400
Autor:
William Brian, Xiaomin Liang, Kathleen M. Giacomini, Dietmar Weitz, Jason M. Kinchen, Katharina Mertsch, Marilyn M. Giacomini, Deanna L. Kroetz, Srijib Goswami, Arik A. Zur, Sook Wah Yee, Annabelle Coelho, Chia Hsiang Hsueh
Publikováno v:
Clinical pharmacology and therapeutics, vol 100, iss 5
Transporter-mediated drug-drug interactions (DDIs) are a major cause of drug toxicities. Using published genome-wide association studies (GWAS) of the human metabolome, we identified 20 metabolites associated with genetic variants in organic anion tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9411301f318dfaac43ff4b9eb346e7
https://escholarship.org/uc/item/6qx1n0sb
https://escholarship.org/uc/item/6qx1n0sb
Autor:
Nils, Rackelmann, Hans, Matter, Heinrich, Englert, Markus, Follmann, Thomas, Maier, John, Weston, Petra, Arndt, Winfried, Heyse, Katharina, Mertsch, Klaus, Wirth, Laurent, Bialy
Publikováno v:
Journal of medicinal chemistry. 59(19)
The design, synthesis, and structure-activity relationship of 1-phenoxy-2-aminoindanes as inhibitors of the Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::29af6020d87fc3185c699ff0a949d9ef
https://pubmed.ncbi.nlm.nih.gov/27606885
https://pubmed.ncbi.nlm.nih.gov/27606885
Autor:
Katharina Mertsch, Jochen Maas
Publikováno v:
Current Medicinal Chemistry-Central Nervous System Agents. 2:187-201
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c90d9ab4c9abe9a95a5f588ebc38cf27
https://doi.org/10.2174/1568015023358067
https://doi.org/10.2174/1568015023358067
Autor:
Friedemann Schmidt, Carsten Strübing, Jörg Czech, Armin Hofmeister, Uwe Dietz, Katharina Mertsch, Nis Halland, Joachim Saas, Matthias Dreyer, Marc Nazaré, Tilo Weiss, Ziyu Li
Publikováno v:
ACS medicinal chemistry letters, 6(1): 73-78
From a virtual screening starting point, inhibitors of the serum and glucocorticoid regulated kinase 1 were developed through a combination of classical medicinal chemistry and library approaches. This resulted in highly active small molecules with n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25c476d762cd233391c0c985971969e6
https://pubmed.ncbi.nlm.nih.gov/25589934
https://pubmed.ncbi.nlm.nih.gov/25589934
Autor:
Ingolf E. Blasig, Martin Paul, Ulrich Walter, Peter Ruth, Reiner F. Haseloff, Albert Smolenski, Katharina Mertsch, Gilbert Schönfelder, Anje Sporbert
Publikováno v:
Molecular Brain Research. 67:258-266
There is contradictory information on the relevance of nitric oxide (NO) and cGMP for the function of brain capillary endothelial cells (BCEC) forming the blood-brain barrier (BBB). Therefore, NO/cGMP-mediated signal transduction was investigated in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b73cc6f1d6601fe3222d977d6ec46e3
https://doi.org/10.1016/s0169-328x(99)00067-4
https://doi.org/10.1016/s0169-328x(99)00067-4
Autor:
Ingolf E. Blasig, Anje Sporbert, Kareen Tenz, Darkhan Utepbergenov, Reiner F. Haseloff, Martin Paul, Katharina Mertsch
Publikováno v:
FEBS Letters. 424:197-201
A cell culture model of blood-brain barrier (BBB, coculture of rat brain endothelial cells with rat astrocytes) was used to investigate the effect of nitric oxide (.NO) on the damage of the BBB induced by hypoxia/reoxygenation (H/R). Permeability coe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::901a183b153d8e674f0a538c695da08a
https://doi.org/10.1016/s0014-5793(98)00173-2
https://doi.org/10.1016/s0014-5793(98)00173-2