Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Katerine Van Rietschoten"'
Autor:
Katherine U. Gaynor, Marina Vaysburd, Maximilian A. J. Harman, Anna Albecka, Phillip Jeffrey, Paul Beswick, Guido Papa, Liuhong Chen, Donna Mallery, Brian McGuinness, Katerine Van Rietschoten, Steven Stanway, Paul Brear, Aleksei Lulla, Katarzyna Ciazynska, Veronica T. Chang, Jo Sharp, Megan Neary, Helen Box, Jo Herriott, Edyta Kijak, Lee Tatham, Eleanor G. Bentley, Parul Sharma, Adam Kirby, Ximeng Han, James P. Stewart, Andrew Owen, John A. G. Briggs, Marko Hyvönen, Michael J. Skynner, Leo C. James
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract COVID-19 has stimulated the rapid development of new antibody and small molecule therapeutics to inhibit SARS-CoV-2 infection. Here we describe a third antiviral modality that combines the drug-like advantages of both. Bicycles are entropica
Externí odkaz:
https://doaj.org/article/83eee9acaa674188b99a7694be9c0c15
Autor:
Sailaja Battula, Kristen Hurov, Johanna lahdenranta, Gemma Mudd, Punit Upadhyaya, Elizabeth Repash, Julia Kristensson, Marianna Kleyman, Jessica Kublin, Liuhong Chen, Eric Haines, Kevin McDonnell, Philip Brandish, Nicholas Keen, Rachel Dods, Rachid Lani, Katerine Van Rietschoten, Tom Stephen, Fanglei You
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss 1 (2021)
Background In contrast to immune checkpoint inhibitors, the use of antibodies as agonists of immune costimulatory receptors as cancer therapeutics has largely failed. We sought to address this problem using a new class of modular synthetic drugs, ter
Externí odkaz:
https://doaj.org/article/2beebb8f72534439867cc69dff340982
Supplementary Figures 1-3 and Tables 1-6 from MMAE Delivery Using the Bicycle Toxin Conjugate BT5528
Autor:
Nicholas Keen, Johanna Lahdenranta, Sophie Watcham, Liuhong Chen, Silvia Pavan, Katerine Van Rietschoten, Philip Huxley, Gemma Mudd, Amy Brown, Gavin Bennett
Supplementary data are provided to further understand the pharmacokinetics and efficacy of BT5528 and EphA2 expression in tumors. Figure S1: Plasma concentration-time curves of BT5528 and MMAE following IV dosing of BT5528 1 in mouse, rat, and cynomo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d028f22c98c3c31042280fe8a7a22e41
https://doi.org/10.1158/1535-7163.22521787.v1
https://doi.org/10.1158/1535-7163.22521787.v1
Autor:
Nicholas Keen, Johanna Lahdenranta, Sophie Watcham, Liuhong Chen, Silvia Pavan, Katerine Van Rietschoten, Philip Huxley, Gemma Mudd, Amy Brown, Gavin Bennett
Supplementary information detailing methods used to generate in vitro and in vivo data presented in paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28102bfe9e7011fdffae4da9f9ba601f
https://doi.org/10.1158/1535-7163.22521784.v1
https://doi.org/10.1158/1535-7163.22521784.v1
Autor:
Nicholas Keen, Johanna Lahdenranta, Sophie Watcham, Liuhong Chen, Silvia Pavan, Katerine Van Rietschoten, Philip Huxley, Gemma Mudd, Amy Brown, Gavin Bennett
Supplementary Chemical Structures provides an inventory and structural diagrams of all Bicycle conjugates used in paper
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7950b471e78d68b5160b6cf58eaf72
https://doi.org/10.1158/1535-7163.22521790
https://doi.org/10.1158/1535-7163.22521790
Autor:
Kevin Lee, Nicholas Keen, Phil Jeffrey, Michael J. Skynner, Johanna Lahdenranta, Eric Haines, Carly Campbell, Peter U. Park, Amy N. Brown, Heather S. Scott, Sophie M. Watcham, Katerine Van Rietschoten, Paul J. Beswick, Helen Harrison, Gemma E. Mudd, Liuhong Chen, Gavin Bennett, Michael Rigby
Supplementary Figure from BT8009; A Nectin-4 Targeting Bicycle Toxin Conjugate for Treatment of Solid Tumors
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0148ec0572dcf04288b6c7ac55148911
https://doi.org/10.1158/1535-7163.22523875
https://doi.org/10.1158/1535-7163.22523875
Autor:
Daniel P. Teufel, Klaus Kopka, Uwe Haberkorn, Karin Leotta, Ursula Schierbaum, Gemma Mudd, Gavin Bennett, Liuhong Chen, Edward H. Walker, Catherine L. Stace, Spencer Campbell, Helen Harrison, Ann-Christin Baranski, Katerine van Rietschoten, Ulrike Bauder-Wüst, Silvia Pavan, Matthias Eder
The file contains supplemental details related to sequence information of the bicyclic peptides referred to in the text, binding data, organ distribution data, PK parameters, mouse and human plasma stability, in vivo metabolism of BCY-B2 in mice, cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48e1ab702f23ec4c672dff01350427c9
https://doi.org/10.1158/0008-5472.22422660
https://doi.org/10.1158/0008-5472.22422660
Autor:
Daniel P. Teufel, Klaus Kopka, Uwe Haberkorn, Karin Leotta, Ursula Schierbaum, Gemma Mudd, Gavin Bennett, Liuhong Chen, Edward H. Walker, Catherine L. Stace, Spencer Campbell, Helen Harrison, Ann-Christin Baranski, Katerine van Rietschoten, Ulrike Bauder-Wüst, Silvia Pavan, Matthias Eder
Molecular imaging of cancers using probes specific for tumor-associated target proteins offers a powerful solution for providing information regarding selection of targeted therapy, patient stratification, and response to therapy. Here we demonstrate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::74b818ef52f548042cc4b5e6e6f5e866
https://doi.org/10.1158/0008-5472.c.6511302.v1
https://doi.org/10.1158/0008-5472.c.6511302.v1
Autor:
Gemma E. Mudd, Heather Scott, Liuhong Chen, Katerine van Rietschoten, Gabriela Ivanova-Berndt, Katarzyna Dzionek, Amy Brown, Sophie Watcham, Lewi White, Peter U. Park, Phil Jeffrey, Mike Rigby, Paul Beswick
Publikováno v:
Journal of medicinal chemistry. 65(21)
Bicycle toxin conjugates (BTCs) are a promising new class of molecules for targeted delivery of toxin payloads into tumors. Herein we describe the discovery of BT8009, a Nectin-4 targeting BTC currently under clinical evaluation. Nectin-4 is overexpr
Autor:
Michael Skynner, Michael J. Dawson, Katerine Van Rietschoten, Catherine Rowland, Helen Harrison, Nicholas Lewis, Gabriela Ivanova-Berndt, Rachel Dods, Paul Beswick, Liuhong Chen, J.M. Wagstaff, Matthew Balmforth
Publikováno v:
ACS Infectious Diseases. 6:2355-2361
The treatment of infection by Gram-negative bacteria is increasingly challenging as resistance to existing antibiotics spreads. Constrained peptides, selected for high target specificity and affinity via library display technologies, are an emerging