Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Katerina Stepanova"'
Autor:
Katerina Stepanova, Miroslav Toman, Jana Sinkorova, Simon Sinkora, Sarka Pfeiferova, Helena Kupcova Skalnikova, Salim Abuhajiar, Romana Moutelikova, Jiri Salat, Hana Stepanova, Katerina Nechvatalova, Lenka Leva, Petra Hermanova, Mirka Kratochvilova, Blanka Dusankova, Marek Sinkora, Vratislav Horak, Tomas Hudcovic, John E. Butler
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
IntroductionPorcine reproductive and respiratory syndrome virus (PRRSV) emerged about 30 years ago and continues to cause major economic losses in the pork industry. The lack of effective modified live vaccines (MLV) allows the pandemic to continue.B
Externí odkaz:
https://doaj.org/article/ebe48e6e668e4b52ac17b2c739319543
Autor:
Hana Stepanova, Marketa Scheirichova, Jan Matiasovic, Karolina Hlavova, Marek Sinkora, Katerina Stepanova, Martin Faldyna
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Interleukin-17A (IL-17) is a pro-inflammatory cytokine involved in the immune response to many pathogens playing also a role in certain chronic and autoimmune diseases. The presented study focused on the early postnatal development of IL-17 producing
Externí odkaz:
https://doaj.org/article/070968928ca44e87a6f1bd498ca6c7d5
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
Studies in humans and mice indicate the critical role of the surrogate light chain in the selection of the productive immunoglobulin repertoire during B cell development. However, subsequent studies using mutant mice have also demonstrated that alter
Externí odkaz:
https://doaj.org/article/357c888607c840838e3f6b881b8a6d74
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Porcine reproductive and respiratory syndrome virus (PRRSV) causes immune dysregulation during the Critical Window of Immunological Development. We hypothesize that thymocyte development is altered by infected thymic antigen presenting cells (TAPCs)
Externí odkaz:
https://doaj.org/article/f91234ea156c4e49ac94bac28b49034d
Autor:
Marek Sinkora, Miroslav Toman, Katerina Stepanova, Hana Stepanova, Lenka Leva, Jana Sinkorova, Romana Moutelikova, Jiri Salat, Dagmar Srutkova, Martin Schwarzer, Simon Sinkora, Helena Kupcova Skalnikova, Katerina Nechvatalova, Tomas Hudcovic, Petra Hermanova, Sarka Pfeiferova, Mirka Kratochvilova, Lenka Kavanova, Blanka Dusankova
Publikováno v:
Microbes and Infection. :105146
Autor:
Jiri Dvorak, Marek Sinkora, Leona Raskova Kafkova, Milan Raska, Zuzana Jiraskova Zakostelska, Dagmar Srutkova, Jiri Mestecky, Renata Stepankova, Jozef Skarda, Luca Vannucci, Zdenek Novak, Helena Tlaskalova-Hogenova, Diana Brokesova, Michal Krupka, Stepan Coufal, Alena Fajstova, Ivo Uberall, Zuzana Stehlikova, Petra Hermanova, Katerina Stepanova
Publikováno v:
Mucosal Immunology
Mucosal surfaces are colonized by highly diverse commensal microbiota. Coating with secretory IgA (SIgA) promotes the survival of commensal bacteria while it inhibits the invasion by pathogens. Bacterial coating could be mediated by antigen-specific
Autor:
Katerina Stepanova, Jana Sinkorova, Dagmar Srutkova, Marek Sinkora, Simon Sinkora, Igor Splichal, Alla Splichalova, John E. Butler
Publikováno v:
Developmental & Comparative Immunology. 131:104392
In pigs (Sus scrofa), the initial immunoglobulin rearrangement of the κ light chain is replaced by λ before the heavy chains rearrange, and the light chains may rearrange even later. This study investigates whether these developmental differences a
Publikováno v:
Developmental and comparative immunology. 126
Swine use a reverse order of immunoglobulin chain rearrangement compared to humans and mice, and this altered and modified order should have measurable consequences. Here we perform new and defining experiments with developing and mature B cells, cha
Publikováno v:
Developmental and comparative immunology. 111
Developmental pathways for B cell lymphogenesis are sufficiently known only in mice and humans. However, both of these species rearrange immunoglobulin heavy chains (IgH) before light chains (IgL) while IgL precedes IgH rearrangement in swine. We dem
Publikováno v:
Developmental and comparative immunology. 99
Porcine thymus contains three independent populations of cells that have rearranged immunoglobulin heavy chain VDJH genes. The first population can be found exclusively in medulla and it consists of existing mature B cells and plasma cells. The secon