Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Katerina Pavelcova"'
Autor:
Aleš Kvasnička, David Friedecký, Radana Brumarová, Markéta Pavlíková, Kateřina Pavelcová, Jana Mašínová, Lenka Hasíková, Jakub Závada, Karel Pavelka, Pavel Ješina, Blanka Stibůrková
Publikováno v:
Arthritis Research & Therapy, Vol 25, Iss 1, Pp 1-16 (2023)
Abstract Background Currently, it is not possible to predict whether patients with hyperuricemia (HUA) will develop gout and how this progression may be affected by urate-lowering treatment (ULT). Our study aimed to evaluate differences in plasma lip
Externí odkaz:
https://doaj.org/article/31ac9cfa6c504c3cbf5bfdb4c1ca733a
Autor:
Yu Toyoda, Sung Kweon Cho, Velibor Tasic, Kateřina Pavelcová, Jana Bohatá, Hiroshi Suzuki, Victor A. David, Jaeho Yoon, Anna Pallaiova, Jana Šaligová, Darryl Nousome, Raul Cachau, Cheryl A. Winkler, Tappei Takada, Blanka Stibůrková
Publikováno v:
Frontiers in Genetics, Vol 13 (2023)
Renal hypouricemia (RHUC) is a pathological condition characterized by extremely low serum urate and overexcretion of urate in the kidney; this inheritable disorder is classified into type 1 and type 2 based on causative genes encoding physiologicall
Externí odkaz:
https://doaj.org/article/ecdfaf66f7f345c7b069c74d26b40df9
Autor:
Yu Toyoda, Kateřina Pavelcová, Jana Bohatá, Pavel Ješina, Yu Kubota, Hiroshi Suzuki, Tappei Takada, Blanka Stiburkova
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1935 (2021)
The ABCG2 gene is a well-established hyperuricemia/gout risk locus encoding a urate transporter that plays a crucial role in renal and intestinal urate excretion. Hitherto, p.Q141K—a common variant of ABCG2 exhibiting approximately one half the cel
Externí odkaz:
https://doaj.org/article/395471d0d21c4d02a50d5ee2862912f8
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Abstract Background ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relati
Externí odkaz:
https://doaj.org/article/eabeafd0922d4141b2c23c10f17ccffb
Publikováno v:
Journal of clinical rheumatology : practical reports on rheumaticmusculoskeletal diseases. 28(2)
Two-hundred patients were assessed for the presence of genetic allelic variants using PCR amplification and direct sequencing.In 19 patients, we detected genetic allelic variants affecting TPMT activity; in 1 case, it was an unpublished heterozygous
Autor:
Eliska Bubenikova, Karel Pavelka, Blanka Stiburkova, Jana Bohatá, Katerina Pavelcova, Marketa Pavlikova
Publikováno v:
Journal of Clinical Medicine, Vol 9, Iss 2510, p 2510 (2020)
Journal of Clinical Medicine
Volume 9
Issue 8
Journal of Clinical Medicine
Volume 9
Issue 8
Urate transporters, which are located in the kidneys, significantly affect the level of uric acid in the body. We looked at genetic variants of genes encoding the major reabsorption proteins GLUT9 (SLC2A9) and URAT1 (SLC22A12) and their association w
Publikováno v:
Arthritis Research & Therapy
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-10 (2019)
Background ABCG2 is a high-capacity urate transporter that plays a crucial role in renal urate overload and extra-renal urate underexcretion. Previous studies have suggested an association between hyperuricemia and gout susceptibility relative to dys
Publikováno v:
Clinica Chimica Acta. 460:46-49
Hyperuricemia depends on the balance of endogenous production and renal excretion of uric acid. Transporters for urate are located in the proximal tubule where uric acid is secreted and extensively reabsorbed: secretion is principally ensured by the
Publikováno v:
Toxicology and applied pharmacology. 353
The aim of our study was to identify the genetic background of thiopurine-induced toxicity in a patient with a wild-type thiopurine methyltransferase genotype and activity. A 38-year-old Caucasian woman presented with cutaneous necrotizing vasculitis
Autor:
Jakub Zavada, Hirotaka Matsuo, Tony R. Merriman, Blanka Stiburkova, Pavel Cepek, Marketa Pavlikova, Katerina Pavelcova, Lenka Petru, Pavel Simek, Karel Pavelka
Publikováno v:
Rheumatology (Oxford, England). 56(11)
Objectives Common dysfunctional variants of ATP binding cassette subfamily G member 2 (Junior blood group) (ABCG2), a high-capacity urate transporter gene, that result in decreased urate excretion are major causes of hyperuricemia and gout. In the pr