Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Katerina Jiroutkova"'
Effect of noradrenaline on propofol-induced mitochondrial dysfunction in human skeletal muscle cells
Autor:
Adéla Krajčová, Christine Skagen, Valér Džupa, Tomáš Urban, Arild C. Rustan, Kateřina Jiroutková, Bohumil Bakalář, G. Hege Thoresen, František Duška
Publikováno v:
Intensive Care Medicine Experimental, Vol 10, Iss 1, Pp 1-14 (2022)
Abstract Background Mitochondrial dysfunction is a hallmark of both critical illness and propofol infusion syndrome and its severity seems to be proportional to the doses of noradrenaline, which patients are receiving. We comprehensively studied the
Externí odkaz:
https://doaj.org/article/b82e34584bbd453fa2f2d26a2cf87767
Autor:
Petr Waldauf, Jan Gojda, Tomáš Urban, Natália Hrušková, Barbora Blahutová, Marie Hejnová, Kateřina Jiroutková, Michal Fric, Pavel Jánský, Jana Kukulová, Francis Stephens, Kamila Řasová, František Duška
Publikováno v:
Trials, Vol 20, Iss 1, Pp 1-11 (2019)
Abstract Background Intensive care unit (ICU)-acquired weakness is the most important cause of failed functional outcome in survivors of critical care. Most damage occurs during the first week when patients are not cooperative enough with conventiona
Externí odkaz:
https://doaj.org/article/ac002098772a418d8c4450f6671fc7ba
Autor:
Tomáš Urban, Petr Waldauf, Adéla Krajčová, Kateřina Jiroutková, Milada Halačová, Valér Džupa, Libor Janoušek, Eva Pokorná, František Duška
Publikováno v:
PLoS ONE, Vol 14, Iss 10, p e0217254 (2019)
IntroductionPropofol causes a profound inhibition of fatty acid oxidation and reduces spare electron transfer chain capacity in a range of human and rodent cells and tissues-a feature that might be related to the pathogenesis of Propofol Infusion Syn
Externí odkaz:
https://doaj.org/article/9740716d94e94138821375a14220b50e
Publikováno v:
Critical Care Research and Practice, Vol 2019 (2019)
Introduction. There is an inverse relationship between cardiac output and the central venous-arterial difference of partial pressures of carbon dioxide (pCO2 gap), and pCO2 gap has been used to guide early resuscitation of septic shock. It can be hyp
Externí odkaz:
https://doaj.org/article/a5379a16ad1241dea9e654d0334d6dc6
Autor:
Jakub Ziak, Moustafa Elkalaf, V Dzupa, Jana Pátková, Katerina Jiroutkova, Jan Trnka, František Duška, Adéla Krajčová
Publikováno v:
Journal of Parenteral and Enteral Nutrition. 39:180-189
Glutamine has been considered essential for rapidly dividing cells, but its effect on mitochondrial function is unknown.Human myoblasts were isolated from skeletal muscle biopsy samples (n = 9) and exposed for 20 days to 6 different glutamine concent
Publikováno v:
Mitochondrion. 21
Using skeletal muscle homogenates for respirometry has many advantages, but the main challenge is avoiding the damage to outer mitochondrial membrane (OMM) and complex I. By optimising the amount of muscle and careful titration of substrates and inhi